STRINGSTRING
ahpC ahpC KSB66854.1 KSB66854.1 nagA nagA nagB nagB KSB66857.1 KSB66857.1 KSB66870.1 KSB66870.1 KSB66891.1 KSB66891.1 galK galK galT galT galE galE KSB67088.1 KSB67088.1 KSB67113.1 KSB67113.1 KSB65866.1 KSB65866.1 KSB65892.1 KSB65892.1 glgC glgC topA_1 topA_1 pgi pgi tsaE tsaE KSB66410.1 KSB66410.1 KSB66411.1 KSB66411.1 KSB66482.1 KSB66482.1 KSB66598.1 KSB66598.1 KSB66686.1 KSB66686.1 KSB65358.1 KSB65358.1 KSB65568.1 KSB65568.1 KSB65587.1 KSB65587.1 KSB65590.1 KSB65590.1 xerD xerD glk glk arnD arnD arnA arnA arnC arnC arnB arnB KSB63908.1 KSB63908.1 crr crr KSB62858.1 KSB62858.1 KSB62918.1 KSB62918.1 KSB62929.1 KSB62929.1 glk-2 glk-2 KSB63019.1 KSB63019.1 KSB61302.1 KSB61302.1 KSB61303.1 KSB61303.1 KSB61307.1 KSB61307.1 KSB60681.1 KSB60681.1 KSB60120.1 KSB60120.1 nagZ nagZ nagK nagK KSB60161.1 KSB60161.1 yihS yihS wecB wecB wecC wecC wcaF wcaF gmd gmd fcl fcl cpsB cpsB KSB59245.1 KSB59245.1 KSB59251.1 KSB59251.1 KSB59253.1 KSB59253.1 galE-2 galE-2 KSB59263.1 KSB59263.1 murQ murQ KSB58869.1 KSB58869.1 manY_1 manY_1 ptsL ptsL glmM glmM murA murA rapZ rapZ nanK nanK nanE nanE nanA nanA msrQ msrQ murB murB galU galU glmS glmS glmU glmU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ahpCAlkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
KSB66854.1Transcriptional regulator; Regulates the synthesis of glucosamine and N-acetylglucosamine by acting as a repressor of the nagEBACD operon and both a repressor and activator of the glmSU operon; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase; Catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa)
KSB66857.1PTS N-acetyl glucosamine transporter subunit IIABC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (650 aa)
KSB66870.1Phosphoglucomutase; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
KSB66891.1DNA recombinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (382 aa)
galTGalactose-1-phosphate uridylyltransferase; Catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (348 aa)
galEUDP-galactose-4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (338 aa)
KSB67088.1Competence protein ComEC; Derived by automated computational analysis using gene prediction method: Protein Homology. (754 aa)
KSB67113.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
KSB65866.1Phosphosugar isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
KSB65892.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (431 aa)
topA_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (549 aa)
tsaEADP-binding protein; Needed for nucleoid integrity; possibly involved in cell wall synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
KSB66410.1Glucosamine--fructose-6-phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
KSB66411.1Glucosamine--fructose-6-phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
KSB66482.1Chitinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (703 aa)
KSB66598.1alpha-N-arabinofuranosidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 43 family. (316 aa)
KSB66686.1Chitinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (587 aa)
KSB65358.1Endolysin; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
KSB65568.1Transcriptional regulator; Mlc, controls the expression of genes involved in the phosphotransferase and phosphoenolpyruvate systems, regulates genes involved in the uptake of sugars; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
KSB65587.1Mannose-6-phosphate isomerase; Catalyzes the formation of of fructose 6-phosphate from mannose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannose-6-phosphate isomerase type 1 family. (391 aa)
KSB65590.1PTS sugar transporter subunit IIBC; Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
xerDRecombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges the bottom [...] (298 aa)
glkGlucokinase; Catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. (321 aa)
arnD4-deoxy-4-formamido-L-arabinose-phospho-UDP deformylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (299 aa)
arnAUDP-4-amino-4-deoxy-L-arabinose formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa)
arnCUDP phosphate 4-deoxy-4-formamido-L-arabinose transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa)
arnBUDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (379 aa)
KSB63908.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
crrPTS glucose transporter subunit IIA; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
KSB62858.1Maltose acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
KSB62918.1Peroxiredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
KSB62929.1Fructokinase; Catalyzes phosphorylation of fructose; cytosolic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
glk-2Glucokinase; Catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
KSB63019.1Endolysin; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
KSB61302.1Phosphosugar isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
KSB61303.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
KSB61307.1PTS mannose transporter subunit IIAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
KSB60681.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)
KSB60120.1PTS glucose-specific subunit IIBC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
nagZBeta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (341 aa)
nagKN-acetylglucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (303 aa)
KSB60161.1Lipoprotein EnvE; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
yihSSugar isomerase; Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF). (413 aa)
wecBUDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (376 aa)
wecCUDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
wcaFAcyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (373 aa)
fclGDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
cpsBMannose-1-phosphate guanyltransferase; Capsular polysaccharide colanic acid biosynthesis protein; catalyzes the formation of GDP-mannose from GTP and alpha-D-mannose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannose-6-phosphate isomerase type 2 family. (478 aa)
KSB59245.1Phosphomannomutase; Capsular polysaccharide biosynthesis protein; catalyzes the formation of D-mannose 6-phosphate from alpha-D-mannose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
KSB59251.1UTP--glucose-1-phosphate uridylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
KSB59253.1Aminotransferase DegT; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. (357 aa)
galE-2UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (346 aa)
KSB59263.1UDP-glucose 6-dehydrogenase; Catalyzes the formation of UDP-glucuronate from UDP-glucose; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
murQN-acetylmuramic acid-6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (297 aa)
KSB58869.1PTS mannose transporter subunit IID; Hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
manY_1PTS mannose transporter subunit IIC; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; the IIC domain forms the PTS system translocation channel and contains the specific substrate-binding site; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
ptsLPTS mannose transporter subunit IIAB; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; subunit IIA transfers a phosphoryl group to subunit IIB; subunit IIB transfers the phosphoryl group to the substrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (445 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
rapZglmZ(sRNA)-inactivating NTPase; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. (284 aa)
nanKN-acetylmannosamine kinase; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (291 aa)
nanEN-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (229 aa)
nanAN-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (297 aa)
msrQSulfite oxidase subunit YedZ; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ p [...] (199 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa)
galUTogether with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa)
Your Current Organism:
Salmonella enterica salamae
NCBI taxonomy Id: 1243604
Other names: S. enterica subsp. salamae serovar 56:z10:e,n,x str. 1369-73, Salmonella enterica subsp. salamae serovar 56:z10:e,n,x str. 1369-73, Salmonella enterica subsp. salamae serovar 56:z10:enx str. SA20011914
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.