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S58_00330 S58_00330 S58_02440 S58_02440 S58_02450 S58_02450 S58_02460 S58_02460 S58_02470 S58_02470 S58_04010 S58_04010 mdh mdh sucC sucC sucD sucD S58_04140 S58_04140 S58_04150 S58_04150 S58_04170 S58_04170 S58_05090 S58_05090 S58_10710 S58_10710 S58_17210 S58_17210 S58_18170 S58_18170 S58_18180 S58_18180 S58_18190 S58_18190 fumC fumC S58_22060 S58_22060 S58_22140 S58_22140 S58_24810 S58_24810 S58_26740 S58_26740 gcvP gcvP gcvH gcvH S58_27030 S58_27030 S58_27340 S58_27340 S58_30590 S58_30590 lipB lipB S58_34670 S58_34670 pdhA pdhA S58_35510 S58_35510 S58_35530 S58_35530 S58_35540 S58_35540 S58_37500 S58_37500 lipA lipA S58_41240 S58_41240 S58_48170 S58_48170 S58_48600 S58_48600 S58_50950 S58_50950 S58_51180 S58_51180 S58_51300 S58_51300 S58_52950 S58_52950 S58_52970 S58_52970 S58_52990 S58_52990 S58_53000 S58_53000 fumC-2 fumC-2 S58_64110 S58_64110 S58_70240 S58_70240 S58_70250 S58_70250
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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S58_00330Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (498 aa)
S58_02440Succinate dehydrogenase cytochrome b556 subunit. (132 aa)
S58_02450Succinate dehydrogenase hydrophobic membrane anchor protein. (132 aa)
S58_02460Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (612 aa)
S58_02470Succinate dehydrogenase, Fe-S protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (260 aa)
S58_04010Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (906 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (322 aa)
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
S58_041402-oxoglutarate dehydrogenase E1 component. (985 aa)
S58_04150Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (410 aa)
S58_04170Dihydrolipoamide dehydrogenase. (467 aa)
S58_05090Putative aminotransferase, class V. (395 aa)
S58_10710Succinate-semialdehyde dehydrogenase I. (481 aa)
S58_17210Conserved exported hypothetical protein. (242 aa)
S58_18170Putative 2-oxoglutarate synthase subunit B, korB-like protein. (351 aa)
S58_181802-oxoglutarate synthase alpha subunit. (616 aa)
S58_181902-ketoglutarate. (599 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (474 aa)
S58_22060Putative Fumarate reductase/succinate dehydrogenase flavoprotein. (459 aa)
S58_22140Putative fumarylacetoacetate hydrolase family protein. (264 aa)
S58_24810Fumarylacetoacetate hydrolase. (233 aa)
S58_26740Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (551 aa)
gcvPGlycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa)
gcvHGlycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (121 aa)
S58_27030Glycine cleavage system T-protein. (385 aa)
S58_27340Putative fumarylacetoacetate hydrolase. (333 aa)
S58_30590Putative pyruvate ferredoxin/flavodoxin oxidoreductase. (1163 aa)
lipBLipoate biosynthesis protein B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (240 aa)
S58_34670Type II citrate synthase; Belongs to the citrate synthase family. (434 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (340 aa)
S58_35510Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (465 aa)
S58_35530Branched-chain alpha-keto acid dehydrogenase subunit E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (450 aa)
S58_35540Dihydrolipoamide dehydrogenase. (473 aa)
S58_37500NAD-dependent succinate aldehyde dehydrogenase. (463 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (319 aa)
S58_41240Malic enzyme. (770 aa)
S58_48170Conserved hypothetical protein. (249 aa)
S58_48600Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
S58_50950Hypothetical protein. (267 aa)
S58_51180Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (432 aa)
S58_51300Putative dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (787 aa)
S58_52950Putative fused malic enzyme oxidoreductase. (758 aa)
S58_52970Lipoamide dehydrogenase, E3 component is part of three enzyme complexes. (581 aa)
S58_52990Pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2. (515 aa)
S58_53000Pyruvate dehydrogenase, decarboxylase component E1, thiamin-binding; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (896 aa)
fumC-2Fumarate hydratase (fumarase C),aerobic Class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
S58_64110Glutamate synthase (NADPH) large chain. (1568 aa)
S58_70240Putative citrate synthase; Belongs to the citrate synthase family. (407 aa)
S58_70250Citrate synthase 2; Belongs to the citrate synthase family. (362 aa)
Your Current Organism:
Bradyrhizobium oligotrophicum
NCBI taxonomy Id: 1245469
Other names: Agromonas oligotrophica LMG 10732, Agromonas oligotrophica S58, B. oligotrophicum S58, Bradyrhizobium oligotrophicum S58
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