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| | S58_72140 | Hypothetical protein. (968 aa) |
| | S58_72220 | Type III secretion system ATPase. (447 aa) |
| | ispDF | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (393 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (226 aa) |
| | S58_38290 | Putative phosphatidylcholine synthase; Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (235 aa) |
| | S58_38180 | Hypothetical protein. (124 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (448 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa) |
| | S58_36590 | Acetyl CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | S58_35510 | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (465 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (164 aa) |
| | S58_35110 | Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (403 aa) |
| | S58_35020 | Unnamed protein product. (520 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (397 aa) |
| | S58_34640 | Hypothetical protein. (285 aa) |
| | lpxA | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (269 aa) |
| | fabZ | (3R)-hydroxymyristoyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | lpxD-2 | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (355 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (407 aa) |
| | S58_34570 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (262 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein, methyltransferase domain; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (342 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (330 aa) |
| | S58_33030 | Guanylate cyclase. (424 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (302 aa) |
| | S58_32400 | Dihydroorotase. (433 aa) |
| | S58_32030 | Quinolinate phosphoribosyltransferase; Belongs to the NadC/ModD family. (282 aa) |
| | plsY | Conserved membrane hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (199 aa) |
| | S58_32020 | L-aspartate oxidase. (517 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (328 aa) |
| | S58_29990 | Acyl carrier protein. (93 aa) |
| | S58_29980 | (3R)-hydroxymyristoyl-ACP dehydratase. (156 aa) |
| | S58_29830 | Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (297 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (232 aa) |
| | S58_29730 | Putative glutamine-dependent NAD(+) synthetase, NadE-like protein. (466 aa) |
| | S58_29720 | Putative diacylglycerol kinase, DgkA-like protein; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (117 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (343 aa) |
| | S58_27670 | Sulfopyruvate decarboxylase alpha subunit. (182 aa) |
| | fdhD | Formate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (278 aa) |
| | S58_25930 | Putative UDP-2,3-diacylglucosamine hydrolase. (253 aa) |
| | S58_25510 | Hydroxy-methylpyrimidine kinase. (266 aa) |
| | S58_25190 | Putative phosphoheptose isomerase. (202 aa) |
| | S58_24860 | Phosphoheptose isomerase. (170 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa) |
| | S58_24140 | Hypothetical protein. (141 aa) |
| | phnN | ATP-binding component, PhnN protein; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (212 aa) |
| | S58_23220 | Molybdenum transport pyrophosphorylase ModD; Belongs to the NadC/ModD family. (288 aa) |
| | S58_23210 | Molybdenum ABC transporter ATP-binding protein. (193 aa) |
| | S58_22060 | Putative Fumarate reductase/succinate dehydrogenase flavoprotein. (459 aa) |
| | S58_20750 | Conserved hypothetical protein. (306 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | lpxC | UDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (319 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (371 aa) |
| | S58_19210 | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (293 aa) |
| | thiS | Thiamine biosynthesis protein ThiS. (65 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (260 aa) |
| | thiE | Thiamine phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (202 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (633 aa) |
| | kynU | Putative kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (397 aa) |
| | S58_17270 | Flagellum-specific ATP synthase. (440 aa) |
| | S58_17230 | Hypothetical protein. (721 aa) |
| | S58_17220 | D-hydantoinase. (467 aa) |
| | cysQ | CysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (277 aa) |
| | S58_16610 | Putative deoxynucleotide monophosphate kinase. (199 aa) |
| | S58_16110 | Conserved hypothetical protein. (518 aa) |
| | S58_15700 | Sulfopyruvate decarboxylase subunit alpha. (181 aa) |
| | S58_15690 | Putative sulfopyruvate decarboxylase beta subunit. (193 aa) |
| | S58_15540 | Ferredoxin. (577 aa) |
| | S58_13670 | Acetyl-coenzyme A synthetase. (535 aa) |
| | carA | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (398 aa) |
| | carB | Carbamoyl phosphate synthase, large subunit; Belongs to the CarB family. (1154 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (369 aa) |
| | S58_12640 | Glyoxalase. (137 aa) |
| | S58_12540 | Putative metallophosphoesterase YkuE. (306 aa) |
| | S58_12250 | Thiamine phosphate pyrophosphorylase. (225 aa) |
| | S58_11890 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. (216 aa) |
| | S58_11560 | 1-acylglycerol-3-phosphate O-acyltransferase. (255 aa) |
| | nadE | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (679 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (322 aa) |
| | S58_10120 | Putative propionyl-CoA synthetase. (634 aa) |
| | S58_09890 | Putative sugar kinase. (548 aa) |
| | S58_09490 | Putative phosphonopyruvate decarboxylase. (340 aa) |
| | S58_08380 | Conserved hypothetical protein. (350 aa) |
| | atpB | ATP synthase subunit A, membrane-bound, F0 sector; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (247 aa) |
| | atpE | ATP synthase F0F1 subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpF-2 | ATP synthase subunit B', membrane-bound, F0 sector; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (196 aa) |
| | atpF | ATP synthase subunit B, membrane-bound, F0 sector; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (163 aa) |
| | pyrD | Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (364 aa) |
| | S58_06690 | Putative AMP-dependent synthetase and ligase. (512 aa) |
| | S58_05610 | Conserved hypothetical protein. (157 aa) |
| | S58_05540 | Baf family transcriptional activator. (101 aa) |
| | S58_05230 | Adenylate/guanylate cyclase. (819 aa) |
| | nadD | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (213 aa) |
| | S58_04280 | Putative adenylate cyclase. (558 aa) |
| | atpC | F0F1 ATP synthase epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (135 aa) |
| | atpD | ATP synthase, F1 beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (480 aa) |
| | atpG | AtpG gene product; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa) |
| | atpA | F0F1 ATP synthase alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (510 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (186 aa) |
| | acsA | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa) |
| | purH | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (530 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (434 aa) |
| | gpsA | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (326 aa) |
| | S58_02880 | Conserved hypothetical protein. (469 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | coaA | Pantothenate kinase. (318 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa) |
| | S58_01830 | Pyrazinamidase/nicotinamidase. (220 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (243 aa) |
| | cmk | Cytidine monophosphate kinase. (212 aa) |
| | accD | Acetyl-coenzyme a carboxylase carboxyl transferase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (312 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | S58_00840 | Coenzyme A biosynthesis bifunctional protein coaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (483 aa) |
| | moeB | Molybdopterin biosynthesis protein MoeB. (268 aa) |
| | S58_00290 | Putative glyoxalase/bleomycin resistance protein/dioxygenase. (132 aa) |
| | purC | Putative phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (304 aa) |
| | S58_39210 | Conserved hypothetical protein; Belongs to the CinA family. (204 aa) |
| | S58_39570 | Lipid A disaccharide synthase. (112 aa) |
| | S58_39790 | Putative formate dehydrogenase (C-terminal), related to acid resistance with formate dehydrogenase/DMSO reductase, domains 1-3 and ADC-like domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (761 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa) |
| | S58_40230 | Hypothetical protein. (211 aa) |
| | S58_41130 | Conserved hypothetical protein. (587 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | purM | Ppx/GppA phosphatase. (357 aa) |
| | S58_41460 | Putative CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. (184 aa) |
| | S58_41520 | Conserved hypothetical protein. (187 aa) |
| | S58_41530 | Molybdenum storage protein beta subunit. (270 aa) |
| | S58_41540 | Molybdenum storage protein alpha subunit. (277 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (333 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (219 aa) |
| | purF | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (507 aa) |
| | S58_43630 | Putative NAD/NADP octopine/nopaline dehydrogenase. (339 aa) |
| | S58_43820 | Phosphoheptose isomerase GmhA. (230 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (534 aa) |
| | guaB | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (495 aa) |
| | S58_44790 | Putative acetyl-CoA synthetase. (576 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (305 aa) |
| | S58_46310 | Putative adenylate/guanylyl cyclase with a CHASE2 domain. (715 aa) |
| | nadK | Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (259 aa) |
| | folE | GTP cyclohydrolase I. (235 aa) |
| | gpt | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (173 aa) |
| | S58_47090 | Conserved hypothetical protein. (245 aa) |
| | S58_47460 | Conserved hypothetical protein. (535 aa) |
| | S58_47810 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (433 aa) |
| | S58_47860 | Lipid kinase. (317 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (736 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (233 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, PurS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (80 aa) |
| | purC-2 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. (265 aa) |
| | S58_48730 | Conserved hypothetical protein. (399 aa) |
| | ispH-2 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (308 aa) |
| | folE-2 | GTP cyclohydrolase. (206 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (494 aa) |
| | S58_52700 | Putative acid-thiol ligase. (562 aa) |
| | S58_52810 | Putative opine dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (364 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (641 aa) |
| | S58_53740 | Putative Adenylate/Guanylate cyclase. (392 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (216 aa) |
| | S58_54820 | Dihydroorotase. (451 aa) |
| | S58_54850 | Putative metal dependent phosphohydrolase. (205 aa) |
| | S58_54960 | L-aspartate oxidase. (532 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (300 aa) |
| | S58_55320 | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (186 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa) |
| | ackA | Propionate kinase/acetate kinase C, anaerobic; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa) |
| | S58_57510 | D-hydantoinase. (489 aa) |
| | upp-2 | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | S58_57840 | Molybdenum ABC transporter ATP-binding protein. (195 aa) |
| | S58_59820 | Molybdopterin-guanine dinucleotide biosynthesis protein B, MobB. (177 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (206 aa) |
| | S58_60660 | Putative Acetoacetyl-coenzyme A synthetase. (682 aa) |
| | napD-2 | Nitrate reductase catalytic subunit; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (834 aa) |
| | S58_60940 | Hypothetical protein. (390 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | S58_62370 | Putative CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (198 aa) |
| | S58_62380 | Molybdenum cofactor biosynthesis protein D. (83 aa) |
| | S58_62390 | Molybdopterin synthase subunit MoaE. (154 aa) |
| | S58_62500 | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. (326 aa) |
| | S58_62740 | Putative adenylate cyclase. (1075 aa) |
| | purD | Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (427 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (335 aa) |
| | S58_62860 | Putative inositol monophosphatase family protein. (269 aa) |
| | S58_63650 | Guanylate cyclase. (273 aa) |
| | S58_64790 | Conserved hypothetical protein. (500 aa) |
| | S58_67110 | Putative competence-damaged protein, CinA like protein; Belongs to the CinA family. (160 aa) |
| | S58_67240 | Putative adenylate/guanylyl cyclase with a CHASE2 domain. (742 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (185 aa) |
| | S58_69530 | Putative AMP-dependent synthetase and ligase. (537 aa) |
| | S58_69560 | Putative gentisate 1,2-dioxygenase with a Cupin, RmlC-type domain. (345 aa) |
| | accA | acetyl-CoA carboxylase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (437 aa) |
| | S58_71950 | Hypothetical protein. (493 aa) |
