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S58_00840 S58_00840 coaE coaE coaA coaA S58_03340 S58_03340 S58_05670 S58_05670 S58_09200 S58_09200 S58_15790 S58_15790 S58_17220 S58_17220 S58_20390 S58_20390 S58_20410 S58_20410 ilvC ilvC panC panC acpS acpS S58_32850 S58_32850 ilvD ilvD S58_38990 S58_38990 S58_39030 S58_39030 coaD coaD S58_41550 S58_41550 panB panB S58_45050 S58_45050 S58_45850 S58_45850 ilvD-2 ilvD-2 S58_50210 S58_50210 S58_51260 S58_51260 S58_51290 S58_51290 ilvD-3 ilvD-3 S58_54330 S58_54330 S58_57510 S58_57510 S58_58270 S58_58270 S58_60490 S58_60490 S58_62120 S58_62120 S58_64240 S58_64240
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
S58_00840Coenzyme A biosynthesis bifunctional protein coaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (483 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa)
coaAPantothenate kinase. (318 aa)
S58_033402-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (307 aa)
S58_05670Putative branched-chain-amino-acid aminotransferase. (295 aa)
S58_09200Putative AtrC acetolactate syntase; Belongs to the TPP enzyme family. (577 aa)
S58_15790Putative acetolactate synthase large subunit. (515 aa)
S58_17220D-hydantoinase. (467 aa)
S58_20390Acetolactate synthase large subunit. (589 aa)
S58_20410Acetolactate synthase small subunit. (180 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa)
acpSAcyl carrier protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (139 aa)
S58_32850Hypothetical protein. (553 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (574 aa)
S58_38990MazG protein. (272 aa)
S58_39030Putative acetolactate synthase. (577 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
S58_41550Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (495 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase 2; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (274 aa)
S58_45050Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (607 aa)
S58_45850Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (509 aa)
ilvD-2Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (612 aa)
S58_50210Putative acetolactate synthase large subunit; Belongs to the TPP enzyme family. (541 aa)
S58_51260Putative dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (568 aa)
S58_51290Aldehyde dehydrogenase. (476 aa)
ilvD-3Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (568 aa)
S58_54330Aldehyde dehydrogenase family 7 member A1 homolog; Belongs to the aldehyde dehydrogenase family. (516 aa)
S58_57510D-hydantoinase. (489 aa)
S58_58270Acetolactate synthase; Belongs to the TPP enzyme family. (570 aa)
S58_60490NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
S58_62120Branched-chain amino acid aminotransferase. (359 aa)
S58_64240Hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (287 aa)
Your Current Organism:
Bradyrhizobium oligotrophicum
NCBI taxonomy Id: 1245469
Other names: Agromonas oligotrophica LMG 10732, Agromonas oligotrophica S58, B. oligotrophicum S58, Bradyrhizobium oligotrophicum S58
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