STRINGSTRING
thyA thyA folA folA gbdR gbdR BAN46138.1 BAN46138.1 BAN46139.1 BAN46139.1 dgcB dgcB dgcA dgcA BAN46142.1 BAN46142.1 BAN46143.1 BAN46143.1 BAN46163.1 BAN46163.1 BAN46164.1 BAN46164.1 ltaE ltaE BAN46172.1 BAN46172.1 glyA glyA soxB soxB soxD soxD soxA soxA soxG soxG purU purU fdhA fdhA glyA-2 glyA-2 purU-2 purU-2 soxG-2 soxG-2 soxA-2 soxA-2 soxD-2 soxD-2 soxB-2 soxB-2 folD folD purU-3 purU-3 gcvT gcvT folD-2 folD-2 purU-4 purU-4 gcvT-2 gcvT-2 BAN47517.1 BAN47517.1 folC folC BAN48291.1 BAN48291.1 gcvH gcvH gcvP gcvP gcvT-3 gcvT-3 BAN48987.1 BAN48987.1 folD-3 folD-3 BAN49967.1 BAN49967.1 gcvH-2 gcvH-2 gcvP-2 gcvP-2 gcvT-4 gcvT-4 BAN50241.1 BAN50241.1 adhC adhC purT purT folM folM glnA glnA gcvP-3 gcvP-3 gcvH-3 gcvH-3 gcvT-5 gcvT-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (170 aa)
gbdRAraC family transcriptional regulator GbdR. (367 aa)
BAN46138.1Putative electron transfer flavoprotein beta subunit. (259 aa)
BAN46139.1Putative electron transfer flavoprotein alpha subunit. (410 aa)
dgcBDimethylglycine catabolism protein DgcB. (652 aa)
dgcADimethylglycine catabolism protein DgcA. (686 aa)
BAN46142.1Hypothetical protein. (176 aa)
BAN46143.1Peptidase M19 family protein. (325 aa)
BAN46163.1Glycine betaine catabolism protein GbcA. (429 aa)
BAN46164.1Glycine betaine catabolism protein GbcB. (367 aa)
ltaEL-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa)
BAN46172.1Creatinase. (403 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
soxBSarcosine oxidase beta subunit. (416 aa)
soxDSarcosine oxidase delta subunit. (108 aa)
soxASarcosine oxidase alpha subunit; Belongs to the GcvT family. (1005 aa)
soxGSarcosine oxidase gamma subunit. (209 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
fdhAGlutathione-independent formaldehyde dehydrogenase. (399 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
soxG-2Sarcosine oxidase gamma subunit. (188 aa)
soxA-2Sarcosine oxidase alpha subunit; Belongs to the GcvT family. (965 aa)
soxD-2Sarcosine oxidase delta subunit. (100 aa)
soxB-2Sarcosine oxidase beta subunit. (413 aa)
folDMethylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (307 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
gcvTAminomethyltransferase; Belongs to the GcvT family. (780 aa)
folD-2Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (303 aa)
purU-4Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
gcvT-2Aminomethyltransferase; Belongs to the GcvT family. (376 aa)
BAN47517.1Putative oxidoreductase. (389 aa)
folCFolylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. (428 aa)
BAN48291.1Hypothetical protein. (262 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
gcvT-3Aminomethyltransferase. (374 aa)
BAN48987.1Putative glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (457 aa)
folD-3Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
BAN49967.1Threonine aldolase. (334 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvP-2Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
gcvT-4Aminomethyltransferase. (372 aa)
BAN50241.1S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (281 aa)
adhCAlcohol dehydrogenase class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (370 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
folMPutative dihydrofolate reductase FolM. (236 aa)
glnAGlutamine synthetase. (467 aa)
gcvP-3Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
gcvH-3Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvT-5Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
Your Current Organism:
Pseudomonas resinovorans NBRC106553
NCBI taxonomy Id: 1245471
Other names: P. resinovorans NBRC 106553, Pseudomonas resinovorans NBRC 106553
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