STRINGSTRING
mcsB mcsB adk adk AIC92696.1 AIC92696.1 AIC92705.1 AIC92705.1 AIC92726.1 AIC92726.1 AIC92744.1 AIC92744.1 AIC92761.1 AIC92761.1 AIC92800.1 AIC92800.1 AIC92856.1 AIC92856.1 iolC iolC AIC92887.1 AIC92887.1 AIC92894.1 AIC92894.1 AIC92917.1 AIC92917.1 AIC92948.1 AIC92948.1 AIC92969.1 AIC92969.1 AIC92976.1 AIC92976.1 rbsK rbsK AIC93012.1 AIC93012.1 AIC93050.1 AIC93050.1 AIC93057.1 AIC93057.1 AIC93146.1 AIC93146.1 AIC93154.1 AIC93154.1 mtnK mtnK AIC93247.1 AIC93247.1 AIC93266.1 AIC93266.1 AIC93298.1 AIC93298.1 AIC93361.1 AIC93361.1 cysC cysC AIC93464.1 AIC93464.1 AIC93488.1 AIC93488.1 AIC93499.1 AIC93499.1 AIC93539.1 AIC93539.1 AIC93548.1 AIC93548.1 AIC93554.1 AIC93554.1 AIC93617.1 AIC93617.1 AIC93653.1 AIC93653.1 AIC93671.1 AIC93671.1 AIC93674.1 AIC93674.1 AIC93720.1 AIC93720.1 AIC93728.1 AIC93728.1 AIC93734.1 AIC93734.1 AIC93754.1 AIC93754.1 AIC93761.1 AIC93761.1 AIC93877.1 AIC93877.1 proB proB AIC93884.1 AIC93884.1 AIC93885.1 AIC93885.1 AIC93919.1 AIC93919.1 AIC93922.1 AIC93922.1 AIC93968.1 AIC93968.1 udk udk AIC94003.1 AIC94003.1 AIC94011.1 AIC94011.1 AIC94065.1 AIC94065.1 AIC94073.1 AIC94073.1 AIC94086.1 AIC94086.1 AIC94116.1 AIC94116.1 AIC94122.1 AIC94122.1 AIC94134.1 AIC94134.1 AIC94151.1 AIC94151.1 AIC94165.1 AIC94165.1 spoIIAB spoIIAB araB araB AIC94333.1 AIC94333.1 AIC94349.1 AIC94349.1 AIC94353.1 AIC94353.1 AIC94381.1 AIC94381.1 AIC94418.1 AIC94418.1 AIC94522.1 AIC94522.1 AIC94539.1 AIC94539.1 ndk ndk cmk cmk AIC94639.1 AIC94639.1 AIC94658.1 AIC94658.1 AIC94673.1 AIC94673.1 AIC94780.1 AIC94780.1 AIC94789.1 AIC94789.1 pyrH pyrH AIC94875.1 AIC94875.1 AIC94880.1 AIC94880.1 gmk gmk aroK aroK nadK nadK AIC95081.1 AIC95081.1 coaA coaA argB argB AIC95143.1 AIC95143.1 AIC95215.1 AIC95215.1 AIC95254.1 AIC95254.1 coaE coaE AIC95268.1 AIC95268.1 AIC95276.1 AIC95276.1 pfkA pfkA ackA ackA AIC95336.1 AIC95336.1 AIC95369.1 AIC95369.1 AIC95370.1 AIC95370.1 AIC95388.1 AIC95388.1 thiM thiM AIC95488.1 AIC95488.1 AIC95490.1 AIC95490.1 thrB thrB pgk pgk hprK hprK AIC95590.1 AIC95590.1 AIC95621.1 AIC95621.1 prs prs AIC95667.1 AIC95667.1 thiL thiL rsbW rsbW AIC95772.1 AIC95772.1 AIC95800.1 AIC95800.1 AIC95862.1 AIC95862.1 AIC95884.1 AIC95884.1 AIC95896.1 AIC95896.1 AIC95957.1 AIC95957.1 AIC95992.1 AIC95992.1 AIC96020.1 AIC96020.1 AIC96074.1 AIC96074.1 AIC96079.1 AIC96079.1 AIC96086.1 AIC96086.1 AIC96095.1 AIC96095.1 AIC96111.1 AIC96111.1 xylB xylB AIC96173.1 AIC96173.1 AIC96223.1 AIC96223.1 AIC96226.1 AIC96226.1 AIC96227.1 AIC96227.1 tdk tdk AIC96290.1 AIC96290.1 AIC96337.1 AIC96337.1 AIC96395.1 AIC96395.1 AIC96412.1 AIC96412.1 AIC96424.1 AIC96424.1 glpK glpK AIC96435.1 AIC96435.1 AIC96459.1 AIC96459.1 AIC96514.1 AIC96514.1 AIC96548.1 AIC96548.1 tmk tmk AIC96589.1 AIC96589.1 ispE ispE prs-2 prs-2 AIC96624.1 AIC96624.1 coaX coaX AIC96636.1 AIC96636.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcsBGuanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. (356 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
AIC92696.1PTS system, glucose-specific enzyme II, ABC component. (681 aa)
AIC92705.1Signal transduction histidine kinase. (461 aa)
AIC92726.1Trifolitoxin immunity domain-containing protein. (262 aa)
AIC92744.1Hypothetical protein. (175 aa)
AIC92761.1Hypothetical protein. (170 aa)
AIC92800.1Phosphotransferase system, enzyme IIB component. (451 aa)
AIC92856.1Histidine kinase. (458 aa)
iolC2-deoxy-5-keto-D-gluconic acid kinase; Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2- deoxy-D-gluconate (DKGP). (328 aa)
AIC92887.1Hypothetical protein. (187 aa)
AIC92894.1Hypothetical protein. (429 aa)
AIC92917.12-keto-3-deoxygluconate kinase. (323 aa)
AIC92948.1Aminoglycoside phosphotransferase domain-contaning protein. (289 aa)
AIC92969.1Sensor histidine kinase domain-containing protein. (501 aa)
AIC92976.1Signal transduction histidine kinase. (737 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (295 aa)
AIC93012.1Protein kinase-like domain-containing protein. (205 aa)
AIC93050.1Phosphotransferase enzyme IIB component. (102 aa)
AIC93057.1Protein kinase-like domain-containing protein. (869 aa)
AIC93146.1PTS system beta-glucoside-specific EIIBCA component. (631 aa)
AIC93154.1Sensor histidine kinase. (568 aa)
mtnKMethylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (406 aa)
AIC93247.1Hypothetical protein. (360 aa)
AIC93266.1Sensor histidine kinase. (377 aa)
AIC93298.1Sensor histidine kinase. (372 aa)
AIC93361.1ATPase, BadF/BadG/BcrA/BcrD type protein. (321 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa)
AIC93464.1Sensor histidine kinase. (348 aa)
AIC93488.1Sensor histidine kinase. (372 aa)
AIC93499.1Protein kinase. (282 aa)
AIC93539.1Protein kinase-like protein. (256 aa)
AIC93548.1Fructokinase. (292 aa)
AIC93554.1Galactokinase; Belongs to the GHMP kinase family. GalK subfamily. (372 aa)
AIC93617.1Sensor histidine kinase. (364 aa)
AIC93653.1Diacylglycerol kinase. (302 aa)
AIC93671.1Glycerol kinase; Belongs to the FGGY kinase family. (506 aa)
AIC93674.1Protein kinase. (272 aa)
AIC93720.1N-acetyltransferase. (178 aa)
AIC93728.1Sensor histidine kinase-related protein. (545 aa)
AIC93734.1Diacylglycerol kinase. (296 aa)
AIC93754.1PTS system, trehalose-specific enzyme II, BC component. (476 aa)
AIC93761.11-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (303 aa)
AIC93877.1Serine protein kinase PrkA. (631 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (366 aa)
AIC93884.1Hypothetical protein. (57 aa)
AIC93885.1Pectin lyase fold protein. (522 aa)
AIC93919.1Sensor histidine kinase. (418 aa)
AIC93922.1NUDIX hydrolase. (134 aa)
AIC93968.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (730 aa)
udkUridine kinase. (216 aa)
AIC94003.1Hypothetical protein. (165 aa)
AIC94011.1Phosphomethylpyrimidine kinase. (270 aa)
AIC94065.1Diacylglycerol kinase. (128 aa)
AIC94073.1Phosphotransferase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (270 aa)
AIC94086.1Sporulation kinase E. (366 aa)
AIC94116.1Glucokinase. (319 aa)
AIC94122.1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (265 aa)
AIC94134.1Sporulation kinase A. (553 aa)
AIC94151.1Aspartokinase; Belongs to the aspartokinase family. (456 aa)
AIC94165.1Glucose-specific phosphotransferase enzyme IIA component. (163 aa)
spoIIABAnti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa)
araBRibulokinase. (562 aa)
AIC94333.1Sensor histidine kinase ykoH. (458 aa)
AIC94349.1Sensor histidine kinase. (311 aa)
AIC94353.1Sensor histidine kinase. (464 aa)
AIC94381.1Two-component sensor histidine kinase. (555 aa)
AIC94418.1Carbohydrate/purine kinase domain-containing protein. (335 aa)
AIC94522.1Gluconokinase; Belongs to the FGGY kinase family. (486 aa)
AIC94539.1Kinase-associated protein. (123 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (148 aa)
cmkCytidylate kinase. (218 aa)
AIC94639.1Sensor histidine kinase. (482 aa)
AIC94658.1Sensor histidine kinase. (591 aa)
AIC94673.1Protein kinase-like domain-containing protein. (553 aa)
AIC94780.1Aspartate kinase I; Belongs to the aspartokinase family. (405 aa)
AIC94789.1Riboflavin kinase domain-containing protein; Belongs to the ribF family. (318 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa)
AIC94875.1Hypothetical protein. (557 aa)
AIC94880.1Serine/threonine protein kinase. (697 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (203 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (180 aa)
nadKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (266 aa)
AIC95081.1GTP pyrophosphokinase. (207 aa)
coaAPantothenate kinase. (316 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (254 aa)
AIC95143.1Chemotaxis protein histidine kinase. (654 aa)
AIC95215.1Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (571 aa)
AIC95254.1Hypothetical protein. (178 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (197 aa)
AIC95268.1Alkaline phosphatase synthesis sensor protein phoR. (568 aa)
AIC95276.1Pyruvate kinase; Belongs to the pyruvate kinase family. (584 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
AIC95336.1Phosphotransferase. (264 aa)
AIC95369.1Deoxypurine kinase. (210 aa)
AIC95370.1Deoxypurine kinase. (209 aa)
AIC95388.1Hypothetical protein. (432 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (259 aa)
AIC95488.1Mannitol-specific phosphotransferase enzyme IIA component. (143 aa)
AIC95490.1PTS system mannitol-specific EIICB component. (573 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (296 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
hprKHPr kinase/phosphorylase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon [...] (311 aa)
AIC95590.1Hypothetical protein. (61 aa)
AIC95621.1Sensor protein degS; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. (376 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa)
AIC95667.1Sensor protein. (582 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa)
rsbWSerine-protein kinase rsbW; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). (158 aa)
AIC95772.1Serine/threonine-protein kinase rsbT. (138 aa)
AIC95800.1Sensor protein kdpD. (228 aa)
AIC95862.1Sensor histidine kinase. (573 aa)
AIC95884.1Hypothetical protein. (477 aa)
AIC95896.1Sensor histidine kinase. (339 aa)
AIC95957.1PTS system sucrose-specific EIIBC component. (469 aa)
AIC95992.1Hypothetical protein. (190 aa)
AIC96020.1GTP pyrophosphokinase ywa. (253 aa)
AIC96074.1Sensor histidine kinase. (612 aa)
AIC96079.1Glycerate kinase; Belongs to the glycerate kinase type-1 family. (378 aa)
AIC96086.1Sensor histidine kinase. (480 aa)
AIC96095.1Mn2+dependent serine/threonine protein kinase. (248 aa)
AIC96111.1Fructose 1-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. (307 aa)
xylBXylulose kinase. (499 aa)
AIC96173.1Sensor histidine kinase protein CitS. (538 aa)
AIC96223.1Sensor kinase CitS. (516 aa)
AIC96226.1Tyrosine-protein kinase YwqD. (231 aa)
AIC96227.1Capsular polysaccharide biosynthesis protein YwqC. (232 aa)
tdkThymidine kinase. (190 aa)
AIC96290.1Sporulation initiation phosphotransferase F. (117 aa)
AIC96337.1Pyridoxine kinase. (269 aa)
AIC96395.1Sensor histidine kinase malK. (540 aa)
AIC96412.1Lipid kinase. (298 aa)
AIC96424.1Sensor histidine kinase. (464 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (498 aa)
AIC96435.1Signal transduction histidine kinase. (526 aa)
AIC96459.1Sensor protein BceS. (334 aa)
AIC96514.1Sensor histidine kinase yycG. (624 aa)
AIC96548.1Hypothetical protein. (313 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
AIC96589.1Sensor protein. (222 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (297 aa)
prs-2Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa)
AIC96624.1Serine/threonine protein kinase. (321 aa)
coaXType III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa)
AIC96636.17,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase. (176 aa)
Your Current Organism:
Bacillus lehensis
NCBI taxonomy Id: 1246626
Other names: B. lehensis G1, Bacillus lehensis G1
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