STRINGSTRING
crgA crgA AFR_00775 AFR_00775 AFR_01465 AFR_01465 alr alr AFR_05075 AFR_05075 AFR_05080 AFR_05080 ftsE ftsE AFR_05850 AFR_05850 AFR_05855 AFR_05855 AFR_07350 AFR_07350 AFR_09000 AFR_09000 murA murA AFR_09455 AFR_09455 AFR_09465 AFR_09465 AFR_09965 AFR_09965 mraZ mraZ rsmH rsmH AFR_09980 AFR_09980 AFR_09985 AFR_09985 murE murE murF murF mraY mraY AFR_10005 AFR_10005 murG murG murC murC AFR_10020 AFR_10020 ftsZ ftsZ AFR_10030 AFR_10030 sepF sepF AFR_10040 AFR_10040 AFR_10045 AFR_10045 AFR_10050 AFR_10050 AFR_10845 AFR_10845 AFR_11425 AFR_11425 AFR_15495 AFR_15495 AFR_16345 AFR_16345 AFR_16805 AFR_16805 AFR_16810 AFR_16810 AFR_17415 AFR_17415 AFR_19945 AFR_19945 AFR_20160 AFR_20160 AFR_30090 AFR_30090 AFR_30950 AFR_30950 AFR_30955 AFR_30955 AFR_30960 AFR_30960 AFR_30965 AFR_30965 AFR_30970 AFR_30970 AFR_31035 AFR_31035 AFR_31840 AFR_31840 AFR_33350 AFR_33350 mraY-2 mraY-2 ddl ddl AFR_37140 AFR_37140 murA-2 murA-2 AFR_38195 AFR_38195 AFR_40370 AFR_40370 murB murB AFR_41560 AFR_41560 AFR_41670 AFR_41670 AFR_42230 AFR_42230 AFR_42860 AFR_42860 AFR_42940 AFR_42940
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
crgAwhiP-like uncharacterized membrane protein; Involved in cell division; Belongs to the CrgA family. (87 aa)
AFR_00775Hypothetical protein; COG2452 Predicted site-specific integrase-resolvase. (69 aa)
AFR_01465Hypothetical protein; COG0791 Cell wall-associated hydrolases (invasion-associated proteins). (548 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (521 aa)
AFR_05075SPBc2 prophage-derived transglycosylase; COG0739 Membrane proteins related to metalloendopeptidases. (281 aa)
AFR_05080Putative M23-family peptidase; COG0739 Membrane proteins related to metalloendopeptidases. (203 aa)
ftsEPutative cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (226 aa)
AFR_05850Cell division protein FtsX; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (291 aa)
AFR_05855Pyruvate decarboxylase isozyme 2; COG0791 Cell wall-associated hydrolases (invasion-associated proteins). (400 aa)
AFR_07350Putative glycosyltransferase; COG0744 Membrane carboxypeptidase (penicillin-binding protein). (716 aa)
AFR_09000COG1876 D-alanyl-D-alanine carboxypeptidase. (202 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (451 aa)
AFR_09455Putative nucleotidyltransferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (276 aa)
AFR_09465Putative ppGpp synthetase; COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (569 aa)
AFR_09965Hypothetical protein; COG0791 Cell wall-associated hydrolases (invasion-associated proteins). (257 aa)
mraZCell division protein MraZ; COG2001 Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. (143 aa)
rsmH16S rRNA m(4)C1402 methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (321 aa)
AFR_09980Hypothetical protein. (196 aa)
AFR_09985COG0768 Cell division protein FtsI/penicillin-binding protein 2. (799 aa)
murEUDP-N-acetylmuramyl tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (504 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate- -D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (462 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (367 aa)
AFR_10005COG0772 Bacterial cell division membrane protein; Belongs to the SEDS family. (484 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (369 aa)
murCPutative UDP-N-acetylmuramoyl-L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (472 aa)
AFR_10020Putative cell division protein FtsQ; Essential cell division protein. (245 aa)
ftsZPutative cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (378 aa)
AFR_10030Hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (237 aa)
sepFHypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (230 aa)
AFR_10040YggT family protein; COG0762 Predicted integral membrane protein. (101 aa)
AFR_10045Putative DivIVA family protein; COG3599 Cell division initiation protein. (273 aa)
AFR_10050Hypothetical protein. (295 aa)
AFR_10845UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. (460 aa)
AFR_11425COG2177 Cell division protein. (153 aa)
AFR_15495Extracellular matrix-binding protein ebhB; COG1876 D-alanyl-D-alanine carboxypeptidase. (351 aa)
AFR_16345Peptidoglycan glycosyltransferase; COG0772 Bacterial cell division membrane protein. (1118 aa)
AFR_16805Hypothetical protein. (268 aa)
AFR_16810Laminin subunit beta-2; COG3599 Cell division initiation protein. (229 aa)
AFR_17415Hypothetical protein. (296 aa)
AFR_19945Putative glycosyltransferase; COG0744 Membrane carboxypeptidase (penicillin-binding protein). (714 aa)
AFR_20160Hypothetical protein; COG4942 Membrane-bound metallopeptidase. (329 aa)
AFR_30090COG3599 Cell division initiation protein. (223 aa)
AFR_30950Hypothetical protein; COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes; Belongs to the MurCDEF family. (913 aa)
AFR_30955COG4242 Cyanophycinase and related exopeptidases; Belongs to the peptidase S51 family. (277 aa)
AFR_30960Putative MFS transporter; COG0477 Permeases of the major facilitator superfamily. (528 aa)
AFR_30965COG1733 Predicted transcriptional regulators. (161 aa)
AFR_30970COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism. (170 aa)
AFR_31035Putative ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (799 aa)
AFR_31840COG1686 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (442 aa)
AFR_33350Hypothetical protein. (92 aa)
mraY-2phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (367 aa)
ddlD-alanyl-alanine synthetase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (367 aa)
AFR_37140COG0768 Cell division protein FtsI/penicillin-binding protein 2. (642 aa)
murA-2UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (428 aa)
AFR_38195Putative glycosyltransferase; COG0744 Membrane carboxypeptidase (penicillin-binding protein). (786 aa)
AFR_40370Putative M23-family peptidase; COG0739 Membrane proteins related to metalloendopeptidases. (273 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (305 aa)
AFR_41560COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4). (454 aa)
AFR_41670Putative glycosyltransferase; COG0744 Membrane carboxypeptidase (penicillin-binding protein). (799 aa)
AFR_42230COG0791 Cell wall-associated hydrolases (invasion-associated proteins). (234 aa)
AFR_42860Putative transglycosylase; COG0744 Membrane carboxypeptidase (penicillin-binding protein). (896 aa)
AFR_42940Putative N-acetylmuramoyl-L-alanine amidase; COG3409 Putative peptidoglycan-binding domain-containing protein. (383 aa)
Your Current Organism:
Actinoplanes friuliensis
NCBI taxonomy Id: 1246995
Other names: A. friuliensis DSM 7358, Actinoplanes friuliensis DSM 7358, Actinoplanes friuliensis HAG 010964
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