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AFR_00630 AFR_00630 ppc ppc eno eno AFR_08965 AFR_08965 AFR_09555 AFR_09555 pfp pfp AFR_10365 AFR_10365 AFR_10565 AFR_10565 pgk pgk tpiA tpiA AFR_10630 AFR_10630 tal tal AFR_10640 AFR_10640 AFR_14280 AFR_14280 pgi pgi eno-2 eno-2 AFR_22880 AFR_22880 AFR_23065 AFR_23065 AFR_23220 AFR_23220 AFR_24840 AFR_24840 AFR_25500 AFR_25500 AFR_27065 AFR_27065 pfkA pfkA AFR_34140 AFR_34140 AFR_34860 AFR_34860 glpX glpX pckG pckG gpmA gpmA AFR_41025 AFR_41025
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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AFR_00630Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (341 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (931 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
AFR_08965COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (353 aa)
AFR_09555Putative sugar kinase; COG1940 Transcriptional regulator/sugar kinase. (316 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
AFR_10365COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (482 aa)
AFR_10565COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa)
AFR_10630Phosphoglucose isomerase. (481 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (379 aa)
AFR_10640COG0021 Transketolase; Belongs to the transketolase family. (702 aa)
AFR_14280Alcohol dehydrogenase GroES domain-containing protein; COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (350 aa)
pgiCOG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. (541 aa)
eno-2Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa)
AFR_22880COG3957 Phosphoketolase. (809 aa)
AFR_23065Phosphoglycerate mutase; COG0406 Fructose-2,6-bisphosphatase. (150 aa)
AFR_23220COG0191 Fructose/tagatose bisphosphate aldolase. (286 aa)
AFR_24840COG0033 Phosphoglucomutase. (547 aa)
AFR_25500ROK family protein; COG1940 Transcriptional regulator/sugar kinase. (348 aa)
AFR_27065Polyphosphate glucokinase; COG1940 Transcriptional regulator/sugar kinase. (259 aa)
pfkADiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (435 aa)
AFR_34140COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
AFR_34860Polyphosphate glucokinase; COG1940 Transcriptional regulator/sugar kinase. (253 aa)
glpXCOG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins. (341 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (599 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (249 aa)
AFR_41025Glucokinase; COG1940 Transcriptional regulator/sugar kinase. (308 aa)
Your Current Organism:
Actinoplanes friuliensis
NCBI taxonomy Id: 1246995
Other names: A. friuliensis DSM 7358, Actinoplanes friuliensis DSM 7358, Actinoplanes friuliensis HAG 010964
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