(35 nodes) Mixed, incl. Fatty acid degradation, and Enoyl-CoA hydratase/isomerase network (Actinoplanes friuliensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AFR_00175	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (293 aa)
	AFR_00190	Putative acyl-CoA carboxylase subunit beta; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (508 aa)
	AFR_00195	COG1960 Acyl-CoA dehydrogenases. (385 aa)
	AFR_00200	Helix-turn-helix domain-containing protein; COG1396 Predicted transcriptional regulators. (829 aa)
	AFR_00430	COG1960 Acyl-CoA dehydrogenases. (618 aa)
	AFR_02230	COG1960 Acyl-CoA dehydrogenases. (389 aa)
	AFR_05410	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	AFR_05570	COG1960 Acyl-CoA dehydrogenases. (384 aa)
	AFR_05620	COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (641 aa)
	AFR_07825	COG1024 Enoyl-CoA hydratase/carnithine racemase. (258 aa)
	AFR_10195	COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (607 aa)
	AFR_10790	COG1024 Enoyl-CoA hydratase/carnithine racemase. (130 aa)
	AFR_11245	acyl-CoA dehydrogenase, short-chain specific; COG1960 Acyl-CoA dehydrogenases. (398 aa)
	AFR_12875	COG1960 Acyl-CoA dehydrogenases. (366 aa)
	AFR_13055	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (249 aa)
	AFR_13130	COG1024 Enoyl-CoA hydratase/carnithine racemase. (278 aa)
	AFR_13420	COG1960 Acyl-CoA dehydrogenases. (542 aa)
	AFR_14615	AMP-dependent synthetase and ligase; COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (591 aa)
	AFR_17570	hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (299 aa)
	AFR_19520	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
	AFR_23160	COG1960 Acyl-CoA dehydrogenases. (573 aa)
	AFR_23290	COG1960 Acyl-CoA dehydrogenases. (663 aa)
	AFR_26215	COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (515 aa)
	AFR_27405	Putative glutaryl-CoA dehydrogenase; COG1960 Acyl-CoA dehydrogenases. (383 aa)
	AFR_28375	COG1960 Acyl-CoA dehydrogenases. (393 aa)
	AFR_35200	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	AFR_35205	Putative 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (689 aa)
	AFR_37025	COG2025 Electron transfer flavoprotein, alpha subunit. (319 aa)
	AFR_37030	Protein fixA; COG2086 Electron transfer flavoprotein, beta subunit. (259 aa)
	AFR_37065	Putative enoyl-CoA hydratase/isomerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (257 aa)
	AFR_37210	Acyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	AFR_37295	COG1250 3-hydroxyacyl-CoA dehydrogenase. (282 aa)
	AFR_38985	COG1960 Acyl-CoA dehydrogenases. (390 aa)
	AFR_38990	COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (511 aa)
	AFR_42355	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (376 aa)

Your Current Organism:

Actinoplanes friuliensis

NCBI taxonomy Id: 1246995
Other names: A. friuliensis DSM 7358, Actinoplanes friuliensis DSM 7358, Actinoplanes friuliensis HAG 010964

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
AFR_00175	AFR_00190	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	Putative acyl-CoA carboxylase subunit beta; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).	0.824
AFR_00175	AFR_05410	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.919
AFR_00175	AFR_05620	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	0.947
AFR_00175	AFR_07825	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.929
AFR_00175	AFR_13055	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).	0.900
AFR_00175	AFR_17570	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	0.910
AFR_00175	AFR_19520	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.919
AFR_00175	AFR_35200	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.919
AFR_00175	AFR_35205	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	Putative 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.420
AFR_00175	AFR_37210	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	Acyltransferase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.919
AFR_00175	AFR_42355	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.919
AFR_00190	AFR_00175	Putative acyl-CoA carboxylase subunit beta; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).	Putative hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	0.824
AFR_00190	AFR_00195	Putative acyl-CoA carboxylase subunit beta; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).	COG1960 Acyl-CoA dehydrogenases.	0.823
AFR_00190	AFR_00200	Putative acyl-CoA carboxylase subunit beta; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).	Helix-turn-helix domain-containing protein; COG1396 Predicted transcriptional regulators.	0.551
AFR_00190	AFR_17570	Putative acyl-CoA carboxylase subunit beta; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).	hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.	0.772
AFR_00190	AFR_35205	Putative acyl-CoA carboxylase subunit beta; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).	Putative 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.541
AFR_00195	AFR_00190	COG1960 Acyl-CoA dehydrogenases.	Putative acyl-CoA carboxylase subunit beta; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).	0.823
AFR_00195	AFR_00200	COG1960 Acyl-CoA dehydrogenases.	Helix-turn-helix domain-containing protein; COG1396 Predicted transcriptional regulators.	0.526
AFR_00195	AFR_05410	COG1960 Acyl-CoA dehydrogenases.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.439
AFR_00195	AFR_07825	COG1960 Acyl-CoA dehydrogenases.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.634