STRINGSTRING
AFR_05515 AFR_05515 AFR_07165 AFR_07165 AFR_31035 AFR_31035 AFR_34940 AFR_34940 AFR_34945 AFR_34945 glnD glnD AFR_36870 AFR_36870 ilvH ilvH AFR_37485 AFR_37485 AFR_41340 AFR_41340 AFR_41745 AFR_41745 pheA pheA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFR_05515COG1171 Threonine dehydratase. (407 aa)
AFR_07165D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (403 aa)
AFR_31035Putative ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (799 aa)
AFR_34940Hypothetical protein; COG0281 Malic enzyme. (253 aa)
AFR_34945Hypothetical protein. (356 aa)
glnDPII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (751 aa)
AFR_36870COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
ilvHCOG0440 Acetolactate synthase, small (regulatory) subunit. (171 aa)
AFR_37485COG0460 Homoserine dehydrogenase. (435 aa)
AFR_41340Putative amino acid-binding protein; COG3830 ACT domain-containing protein. (167 aa)
AFR_41745COG0527 Aspartokinases; Belongs to the aspartokinase family. (421 aa)
pheACOG0077 Prephenate dehydratase. (318 aa)
Your Current Organism:
Actinoplanes friuliensis
NCBI taxonomy Id: 1246995
Other names: A. friuliensis DSM 7358, Actinoplanes friuliensis DSM 7358, Actinoplanes friuliensis HAG 010964
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.