STRINGSTRING
AFR_00015 AFR_00015 AFR_05565 AFR_05565 proC proC AFR_11625 AFR_11625 AFR_15655 AFR_15655 AFR_15665 AFR_15665 AFR_16015 AFR_16015 AFR_16505 AFR_16505 AFR_16865 AFR_16865 AFR_18780 AFR_18780 AFR_20805 AFR_20805 AFR_22245 AFR_22245 AFR_22725 AFR_22725 AFR_24820 AFR_24820 AFR_25255 AFR_25255 AFR_25800 AFR_25800 AFR_26145 AFR_26145 AFR_27345 AFR_27345 AFR_33610 AFR_33610 AFR_35205 AFR_35205 AFR_36385 AFR_36385 gpsA gpsA ilvC ilvC AFR_37295 AFR_37295 AFR_41395 AFR_41395 AFR_41915 AFR_41915 AFR_42095 AFR_42095
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFR_000156-phosphogluconate dehydrogenase-like protein; COG1023 Predicted 6-phosphogluconate dehydrogenase. (290 aa)
AFR_05565Nucleotide sugar dehydrogenase; COG1004 Predicted UDP-glucose 6-dehydrogenase. (479 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa)
AFR_11625Putative UDP-glucose/GDP-mannose dehydrogenase; COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (418 aa)
AFR_15655COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (289 aa)
AFR_156656-phosphogluconate dehydrogenase, NAD-binding protein; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (299 aa)
AFR_16015COG1004 Predicted UDP-glucose 6-dehydrogenase. (437 aa)
AFR_16505Nucleotide sugar dehydrogenase; COG1004 Predicted UDP-glucose 6-dehydrogenase. (480 aa)
AFR_16865COG0246 Mannitol-1-phosphate/altronate dehydrogenases. (405 aa)
AFR_18780COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (261 aa)
AFR_208053-hydroxybutyryl-CoA dehydrogenase PaaC; COG1250 3-hydroxyacyl-CoA dehydrogenase. (285 aa)
AFR_22245COG1893 Ketopantoate reductase. (614 aa)
AFR_22725COG1004 Predicted UDP-glucose 6-dehydrogenase. (437 aa)
AFR_24820Putative 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa)
AFR_25255COG0246 Mannitol-1-phosphate/altronate dehydrogenases. (494 aa)
AFR_25800COG0246 Mannitol-1-phosphate/altronate dehydrogenases. (492 aa)
AFR_261452-hydroxy-3-oxopropionate reductase; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (297 aa)
AFR_27345COG1004 Predicted UDP-glucose 6-dehydrogenase. (455 aa)
AFR_33610Dehydrogenase; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (271 aa)
AFR_35205Putative 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (689 aa)
AFR_36385NDP-N-acetyl-D-galactosaminuronic acid dehydrogenase; COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (420 aa)
gpsACOG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (326 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
AFR_37295COG1250 3-hydroxyacyl-CoA dehydrogenase. (282 aa)
AFR_41395Hypothetical protein. (295 aa)
AFR_41915COG0287 Prephenate dehydrogenase. (330 aa)
AFR_420952-hydroxy-3-oxopropionate reductase; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (244 aa)
Your Current Organism:
Actinoplanes friuliensis
NCBI taxonomy Id: 1246995
Other names: A. friuliensis DSM 7358, Actinoplanes friuliensis DSM 7358, Actinoplanes friuliensis HAG 010964
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.