(34 nodes) NAD dependent epimerase/dehydratase family network (Actinoplanes friuliensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AFR_23340	Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (216 aa)
	AFR_00260	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (357 aa)
	AFR_02690	Putative polysaccharide biosynthesis protein; COG1086 Predicted nucleoside-diphosphate sugar epimerases. (323 aa)
	AFR_09250	Hypothetical protein; COG1090 Predicted nucleoside-diphosphate sugar epimerase. (305 aa)
	AFR_09610	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (293 aa)
	AFR_10700	3-oxoacyl-ACP reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (245 aa)
	AFR_11040	3-oxoacyl-ACP reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (234 aa)
	AFR_11620	Putative polysaccharide biosynthesis protein; COG1086 Predicted nucleoside-diphosphate sugar epimerases. (668 aa)
	AFR_11960	Short chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (261 aa)
	AFR_12570	Oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (255 aa)
	AFR_12775	NmrA family protein; COG0702 Predicted nucleoside-diphosphate-sugar epimerases. (279 aa)
	AFR_13055	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (249 aa)
	AFR_14725	Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (225 aa)
	AFR_14830	Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (290 aa)
	AFR_16035	Putative dTDP-glucose-4,6-dehydratase; COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (324 aa)
	AFR_16040	dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (290 aa)
	AFR_16580	Putative short-chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (224 aa)
	AFR_18115	Nucleoside-diphosphate-sugar epimerase. (166 aa)
	AFR_18260	Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (251 aa)
	AFR_19685	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (276 aa)
	AFR_21255	Putative reductase; COG0451 Nucleoside-diphosphate-sugar epimerases. (326 aa)
	AFR_21445	Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (262 aa)
	AFR_22585	Oxidoreductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (322 aa)
	AFR_23500	Epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases. (342 aa)
	AFR_23735	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (276 aa)
	AFR_26140	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (274 aa)
	AFR_30335	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (281 aa)
	AFR_30800	COG1091 dTDP-4-dehydrorhamnose reductase. (265 aa)
	AFR_32190	Hypothetical protein; COG0702 Predicted nucleoside-diphosphate-sugar epimerases. (214 aa)
	AFR_33175	Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (231 aa)
	AFR_38935	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (339 aa)
	AFR_39630	COG1087 UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (325 aa)
	AFR_40220	Putative NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (361 aa)
	AFR_42500	Nad-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (321 aa)

Your Current Organism:

Actinoplanes friuliensis

NCBI taxonomy Id: 1246995
Other names: A. friuliensis DSM 7358, Actinoplanes friuliensis DSM 7358, Actinoplanes friuliensis HAG 010964

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
AFR_00260	AFR_42500	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	Nad-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.441
AFR_09610	AFR_18115	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	Nucleoside-diphosphate-sugar epimerase.	0.774
AFR_16035	AFR_16040	Putative dTDP-glucose-4,6-dehydratase; COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.	0.997
AFR_16035	AFR_23500	Putative dTDP-glucose-4,6-dehydratase; COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	Epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.825
AFR_16035	AFR_30800	Putative dTDP-glucose-4,6-dehydratase; COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	COG1091 dTDP-4-dehydrorhamnose reductase.	0.990
AFR_16035	AFR_39630	Putative dTDP-glucose-4,6-dehydratase; COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	COG1087 UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.550
AFR_16035	AFR_42500	Putative dTDP-glucose-4,6-dehydratase; COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	Nad-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.926
AFR_16040	AFR_16035	dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.	Putative dTDP-glucose-4,6-dehydratase; COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	0.997
AFR_16040	AFR_23500	dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.	Epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.919
AFR_16040	AFR_30800	dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.	COG1091 dTDP-4-dehydrorhamnose reductase.	0.928
AFR_16040	AFR_42500	dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.	Nad-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.865
AFR_18115	AFR_09610	Nucleoside-diphosphate-sugar epimerase.	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.774
AFR_18115	AFR_19685	Nucleoside-diphosphate-sugar epimerase.	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.761
AFR_19685	AFR_18115	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	Nucleoside-diphosphate-sugar epimerase.	0.761
AFR_23500	AFR_16035	Epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases.	Putative dTDP-glucose-4,6-dehydratase; COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	0.825
AFR_23500	AFR_16040	Epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases.	dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.	0.919
AFR_23500	AFR_30800	Epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases.	COG1091 dTDP-4-dehydrorhamnose reductase.	0.919
AFR_23500	AFR_42500	Epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases.	Nad-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.813
AFR_23735	AFR_38935	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.916
AFR_23735	AFR_39630	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	COG1087 UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.909