(22 nodes) RNA degradation network (Actinoplanes friuliensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	dnaK	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (632 aa)
	rho	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (405 aa)
	AFR_04065	COG0514 Superfamily II DNA helicase. (718 aa)
	groL	60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
	eno	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
	AFR_05455	Putative polyphosphate kinase. (324 aa)
	AFR_07670	Hypothetical protein; COG1530 Ribonucleases G and E. (961 aa)
	AFR_11840	COG0514 Superfamily II DNA helicase. (539 aa)
	AFR_19690	COG0514 Superfamily II DNA helicase. (613 aa)
	eno-2	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa)
	AFR_24580	COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. (559 aa)
	AFR_25845	Hypothetical protein; COG0443 Molecular chaperone. (1043 aa)
	pfkA	Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (435 aa)
	AFR_31270	COG0514 Superfamily II DNA helicase. (548 aa)
	rny	Putative metal-dependent phosphohydrolase; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (574 aa)
	rnj	Putative hydrolase; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (562 aa)
	pnp	Polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (777 aa)
	ppk	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (756 aa)
	AFR_37055	Heat shock protein 70; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family. (597 aa)
	rho-2	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (733 aa)
	groEL	Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (540 aa)
	AFR_42900	Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (476 aa)

Your Current Organism:

Actinoplanes friuliensis

NCBI taxonomy Id: 1246995
Other names: A. friuliensis DSM 7358, Actinoplanes friuliensis DSM 7358, Actinoplanes friuliensis HAG 010964

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFR_05455	ppk	AFR_05455	AFR_36670	Putative polyphosphate kinase.	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	0.969
AFR_07670	AFR_24580	AFR_07670	AFR_24580	Hypothetical protein; COG1530 Ribonucleases G and E.	COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	0.648
AFR_07670	AFR_42900	AFR_07670	AFR_42900	Hypothetical protein; COG1530 Ribonucleases G and E.	Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	0.591
AFR_07670	eno	AFR_07670	AFR_05325	Hypothetical protein; COG1530 Ribonucleases G and E.	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.	0.910
AFR_07670	eno-2	AFR_07670	AFR_22735	Hypothetical protein; COG1530 Ribonucleases G and E.	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.	0.910
AFR_07670	pnp	AFR_07670	AFR_35910	Hypothetical protein; COG1530 Ribonucleases G and E.	Polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.	0.974
AFR_07670	rho	AFR_07670	AFR_01140	Hypothetical protein; COG1530 Ribonucleases G and E.	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.	0.446
AFR_07670	rho-2	AFR_07670	AFR_37450	Hypothetical protein; COG1530 Ribonucleases G and E.	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.	0.457
AFR_07670	rnj	AFR_07670	AFR_35840	Hypothetical protein; COG1530 Ribonucleases G and E.	Putative hydrolase; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.	0.657
AFR_24580	AFR_07670	AFR_24580	AFR_07670	COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	Hypothetical protein; COG1530 Ribonucleases G and E.	0.648
AFR_24580	pnp	AFR_24580	AFR_35910	COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	Polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.	0.872
AFR_25845	AFR_37055	AFR_25845	AFR_37055	Hypothetical protein; COG0443 Molecular chaperone.	Heat shock protein 70; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.	0.926
AFR_25845	dnaK	AFR_25845	AFR_00520	Hypothetical protein; COG0443 Molecular chaperone.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.929
AFR_25845	eno	AFR_25845	AFR_05325	Hypothetical protein; COG0443 Molecular chaperone.	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.	0.558
AFR_25845	eno-2	AFR_25845	AFR_22735	Hypothetical protein; COG0443 Molecular chaperone.	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.	0.546
AFR_25845	groEL	AFR_25845	AFR_40885	Hypothetical protein; COG0443 Molecular chaperone.	Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.822
AFR_25845	groL	AFR_25845	AFR_04920	Hypothetical protein; COG0443 Molecular chaperone.	60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.825
AFR_37055	AFR_25845	AFR_37055	AFR_25845	Heat shock protein 70; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.	Hypothetical protein; COG0443 Molecular chaperone.	0.926
AFR_37055	dnaK	AFR_37055	AFR_00520	Heat shock protein 70; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.928
AFR_37055	eno	AFR_37055	AFR_05325	Heat shock protein 70; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.	0.540