STRINGSTRING
pyrD pyrD pyrE pyrE pyrDII pyrDII asnB asnB purE purE purK purK purN purN purM purM folD folD glyA glyA purA purA pyrF pyrF purB purB purF purF folC folC guaA guaA guaB guaB carB carB carA carA EBS_1802 EBS_1802 purL purL purC purC pyrR pyrR pyrB pyrB EBS_1907 EBS_1907 purH purH purD purD EBS_2063 EBS_2063 folA folA thyA thyA EBS_2285 EBS_2285 EBS_2338 EBS_2338
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrDDihydroorotate dehydrogenase (fumarate); Catalyzes the conversion of dihydroorotate to orotate. (321 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (212 aa)
pyrDIIDihydroorotate dehydrogenase electron transfer subunit. (287 aa)
asnBAsparagine synthase (glutamine-hydrolysing). (587 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (221 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (352 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (236 aa)
purBAdenylosuccinate lyase; Probable gene remnant. OmpA-OmpF porin, OOP family; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (494 aa)
folCDihydrofolate synthase/folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (424 aa)
guaAGMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (525 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1069 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (367 aa)
EBS_1802Dihydroorotase. (444 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1288 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (294 aa)
pyrRPyrimidine operon attenuation protein/uracil phosphoribosyltransferase. (178 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (328 aa)
EBS_1907Dihydroorotase. (434 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (520 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (432 aa)
EBS_2063Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (168 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa)
EBS_2285HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family. (226 aa)
EBS_23385-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (180 aa)
Your Current Organism:
endosymbiont of unidentified
NCBI taxonomy Id: 1248727
Other names: e. of unidentified scaly snail isolate Monju, endosymbiont of unidentified scaly snail isolate Monju
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.