(6 nodes) Mixed, incl. GMP biosynthesis, and De novo AMP biosynthetic process network (endosymbiont of unidentified)

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second shell of interactors

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Your Input:
	asnB	Asparagine synthase (glutamine-hydrolysing). (587 aa)
	purA	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
	guaA	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (525 aa)
	guaB	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
	EBS_2063	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
	EBS_2285	HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family. (226 aa)

Your Current Organism:

endosymbiont of unidentified

NCBI taxonomy Id: 1248727
Other names: e. of unidentified scaly snail isolate Monju, endosymbiont of unidentified scaly snail isolate Monju

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EBS_2063	EBS_2285	EBS_2063	EBS_2285	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family.	0.900
EBS_2063	guaA	EBS_2063	EBS_1403	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	0.972
EBS_2063	guaB	EBS_2063	EBS_1404	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.949
EBS_2063	purA	EBS_2063	EBS_0857	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.506
EBS_2285	EBS_2063	EBS_2285	EBS_2063	HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family.	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.900
EBS_2285	guaA	EBS_2285	EBS_1403	HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family.	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	0.917
EBS_2285	guaB	EBS_2285	EBS_1404	HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.910
EBS_2285	purA	EBS_2285	EBS_0857	HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family.	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.905
asnB	guaA	EBS_0509	EBS_1403	Asparagine synthase (glutamine-hydrolysing).	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	0.525
asnB	purA	EBS_0509	EBS_0857	Asparagine synthase (glutamine-hydrolysing).	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.929
guaA	EBS_2063	EBS_1403	EBS_2063	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.972
guaA	EBS_2285	EBS_1403	EBS_2285	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family.	0.917
guaA	asnB	EBS_1403	EBS_0509	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	Asparagine synthase (glutamine-hydrolysing).	0.525
guaA	guaB	EBS_1403	EBS_1404	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	purA	EBS_1403	EBS_0857	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.901
guaB	EBS_2063	EBS_1404	EBS_2063	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.949
guaB	EBS_2285	EBS_1404	EBS_2285	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	HAD-superfamily hydrolase; Probable gene remnant. transposase IS116/IS110/IS902 family.	0.910
guaB	guaA	EBS_1404	EBS_1403	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	0.999
guaB	purA	EBS_1404	EBS_0857	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.991
purA	EBS_2063	EBS_0857	EBS_2063	Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Nucleoside-triphosphatase THEP1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.506