STRINGSTRING
ALO46397.1 ALO46397.1 fliA fliA ALO46304.1 ALO46304.1 ALO46294.1 ALO46294.1 ALO46293.1 ALO46293.1 selO selO tsaC tsaC glnD glnD ALO46171.1 ALO46171.1 dnaX dnaX dnaQ dnaQ ALO45784.1 ALO45784.1 ALO46052.1 ALO46052.1 ALO45719.1 ALO45719.1 ALO45737.1 ALO45737.1 dnaE2 dnaE2 ALO46042.1 ALO46042.1 ALO46025.1 ALO46025.1 ALO46007.1 ALO46007.1 ALO44830.1 ALO44830.1 ALO45957.1 ALO45957.1 ALO44812.1 ALO44812.1 ispD ispD ALO45613.1 ALO45613.1 ALO45337.1 ALO45337.1 PS2015_60 PS2015_60 ALO45204.1 ALO45204.1 ALO45203.1 ALO45203.1 thiI thiI PS2015_43 PS2015_43 ALO45101.1 ALO45101.1 polA polA ALO45048.1 ALO45048.1 dinB dinB hldE hldE glmU glmU glnE glnE rpoZ rpoZ ALO47633.1 ALO47633.1 ALO47609.1 ALO47609.1 rph rph coaD coaD ALO47540.1 ALO47540.1 ALO47495.1 ALO47495.1 ALO47454.1 ALO47454.1 dnaG dnaG cca cca ALO47362.1 ALO47362.1 ALO47357.1 ALO47357.1 pnp pnp rpoB rpoB rpoC rpoC rpoA rpoA pcnB pcnB ALO46970.1 ALO46970.1 cysN cysN cysD cysD ALO46832.1 ALO46832.1 nadD nadD ALO46801.1 ALO46801.1 ALO46798.1 ALO46798.1 PS2015_2 PS2015_2 ALO44890.1 ALO44890.1 ALO46563.1 ALO46563.1 kdsB kdsB ALO46418.1 ALO46418.1 ALO46405.1 ALO46405.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALO46397.1Pfam:pfam00990 GGDEF domain. (258 aa)
fliARNA polymerase sigma factor FliA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (240 aa)
ALO46304.1Molybdopterin biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (171 aa)
ALO46294.1Hypothetical protein. (140 aa)
ALO46293.1Diguanylate cyclase; Pfam:pfam00990 GGDEF domain. (302 aa)
selOHypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family. (530 aa)
tsaCThreonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (193 aa)
glnDBifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (892 aa)
ALO46171.1Pfam:pfam13177 DNA polymerase III, delta subunit. (323 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (560 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (238 aa)
ALO45784.1Diguanylate cyclase; Pfam:pfam00990 GGDEF domain. (381 aa)
ALO46052.1Pfam:pfam07733 Bacterial DNA polymerase III alpha subunit. (1184 aa)
ALO45719.1Pfam:pfam06574 FAD synthetase; Belongs to the ribF family. (317 aa)
ALO45737.1Hypothetical protein; Pfam:pfam00990 GGDEF domain. (409 aa)
dnaE2DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1045 aa)
ALO46042.1Pfam:pfam01148 Cytidylyltransferase family; Belongs to the CDS family. (286 aa)
ALO46025.1Molybdopterin-guanine dinucleotide biosynthesis protein MobA; Pfam:pfam12804 MobA-like NTP transferase domain. (193 aa)
ALO46007.1Diguanylate cyclase; Pfam:pfam00990 GGDEF domain. (329 aa)
ALO44830.1Hypothetical protein; Pfam:pfam00990 GGDEF domain. (362 aa)
ALO45957.1Hypothetical protein; Pfam:pfam00990 GGDEF domain. (350 aa)
ALO44812.1Hypothetical protein. (441 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (233 aa)
ALO45613.1Hypothetical protein; Pfam:pfam00990 GGDEF domain. (381 aa)
ALO45337.1Diguanylate cyclase; Pfam:pfam00990 GGDEF domain. (480 aa)
PS2015_60Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (299 aa)
ALO45204.1UTP--glucose-1-phosphate uridylyltransferase; Pfam:pfam00483 Nucleotidyl transferase. (275 aa)
ALO45203.1Mannose-1-phosphate guanylyltransferase; Pfam:pfam01050 Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family. (497 aa)
thiItRNA s(4)U8 sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (484 aa)
PS2015_43Hypothetical protein; Pfam:pfam00990 GGDEF domain. (658 aa)
ALO45101.1Hypothetical protein; Pfam:pfam00072 Response regulator receiver domain. (157 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (924 aa)
ALO45048.1Hypothetical protein; Pfam:pfam00990 GGDEF domain. (364 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (358 aa)
hldENucleotidyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)
glmUBifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (457 aa)
glnEGlutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (989 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (107 aa)
ALO47633.1Diguanylate cyclase; Pfam:pfam00990 GGDEF domain. (390 aa)
ALO47609.1Hypothetical protein; Pfam:pfam03755 YicC-like family, N-terminal region. (288 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (248 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
ALO47540.1Signal transduction family protein (GGDEF domain protein); Pfam:pfam00990 GGDEF domain. (325 aa)
ALO47495.1Hypothetical protein; Pfam:pfam00990 GGDEF domain. (490 aa)
ALO47454.1Hypothetical protein; Pfam:pfam00990 GGDEF domain. (330 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (605 aa)
ccaMultifunctional CCA protein; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (420 aa)
ALO47362.1Mannose-1-phosphate guanylyltransferase; Pfam:pfam00483 Nucleotidyl transferase. (226 aa)
ALO47357.1Diguanylate cyclase (GGDEF) domain-containing protein; Pfam:pfam00990 GGDEF domain. (364 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (704 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1361 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1409 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (330 aa)
pcnBpoly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (511 aa)
ALO46970.1RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (498 aa)
cysNAdenylylsulfate kinase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (636 aa)
cysDSulfate adenylyltransferase subunit 2; Pfam:pfam01507 Phosphoadenosine phosphosulfate reductase family. (302 aa)
ALO46832.1Hypothetical protein; Pfam:pfam00990 GGDEF domain. (510 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (215 aa)
ALO46801.1Hypothetical protein. (460 aa)
ALO46798.1Pfam:pfam06144 DNA polymerase III, delta subunit. (346 aa)
PS2015_2DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (368 aa)
ALO44890.1Hypothetical protein. (294 aa)
ALO46563.1Pfam:pfam00078 Reverse transcriptase (RNA-dependent DNA polymerase). (356 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (245 aa)
ALO46418.1Glucose-1-phosphate cytidylyltransferase; Pfam:pfam00483 Nucleotidyl transferase. (257 aa)
ALO46405.1Mannose-1-phosphate guanyltransferase; Pfam:pfam00483 Nucleotidyl transferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (356 aa)
Your Current Organism:
Pseudohongiella spirulinae
NCBI taxonomy Id: 1249552
Other names: KCTC 32221, LMG 27470, LMG:27470, Nonhongiella spirulinensis, P. spirulinae, Pseudohongiella spirulinae corrig. Wang et al. 2015, gamma proteobacterium Ma-20, strain Ma-20
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