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hemA hemA cysG cysG hemF hemF ALO44868.1 ALO44868.1 ALO47125.1 ALO47125.1 hemL hemL ALO47191.1 ALO47191.1 hemE hemE cyoE cyoE hemH hemH hemC hemC ALO45115.1 ALO45115.1 ALO45117.1 ALO45117.1 ALO45121.1 ALO45121.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (435 aa)
cysGSirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (463 aa)
hemFCoproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (310 aa)
ALO44868.1Pfam:pfam03992 Antibiotic biosynthesis monooxygenase. (100 aa)
ALO47125.1Putative membrane protein; Pfam:pfam03653 Uncharacterized protein family (UPF0093). (140 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase; Pfam:pfam00202 Aminotransferase class-III. (434 aa)
ALO47191.1Amine oxidase; Pfam:pfam01593 Flavin containing amine oxidoreductase. (427 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa)
cyoEProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (328 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (359 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa)
ALO45115.1Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (262 aa)
ALO45117.1Pfam:pfam07219 HemY protein N-terminus. (80 aa)
ALO45121.1Hypothetical protein; Pfam:pfam00490 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (337 aa)
Your Current Organism:
Pseudohongiella spirulinae
NCBI taxonomy Id: 1249552
Other names: KCTC 32221, LMG 27470, LMG:27470, Nonhongiella spirulinensis, P. spirulinae, Pseudohongiella spirulinae corrig. Wang et al. 2015, gamma proteobacterium Ma-20, strain Ma-20
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