STRINGSTRING
yajC yajC secD secD bamB bamB ffh ffh ALO45916.1 ALO45916.1 secD-2 secD-2 bamA bamA ALO46046.1 ALO46046.1 tig tig ALO46153.1 ALO46153.1 ALO46154.1 ALO46154.1 ALO46155.1 ALO46155.1 ALO46156.1 ALO46156.1 lolA lolA ALO46226.1 ALO46226.1 ALO46325.1 ALO46325.1 flhA flhA flhB flhB ALO46328.1 ALO46328.1 fliQ fliQ fliP fliP ALO46336.1 ALO46336.1 ALO46337.1 ALO46337.1 ALO46465.1 ALO46465.1 ALO46466.1 ALO46466.1 ALO46468.1 ALO46468.1 lolD lolD ALO46470.1 ALO46470.1 ALO46557.1 ALO46557.1 tolB tolB ALO46622.1 ALO46622.1 tolR tolR tolQ tolQ bamD bamD ALO46776.1 ALO46776.1 ALO46845.1 ALO46845.1 ALO46915.1 ALO46915.1 ALO46916.1 ALO46916.1 secA secA ALO46940.1 ALO46940.1 ALO47022.1 ALO47022.1 ALO47023.1 ALO47023.1 ALO47024.1 ALO47024.1 ALO47025.1 ALO47025.1 ALO47026.1 ALO47026.1 ALO47027.1 ALO47027.1 ALO47028.1 ALO47028.1 ALO47029.1 ALO47029.1 ALO47030.1 ALO47030.1 ALO47031.1 ALO47031.1 ALO47032.1 ALO47032.1 ALO47033.1 ALO47033.1 ALO47035.1 ALO47035.1 secY secY secE secE bamE bamE ALO44943.1 ALO44943.1 ALO47182.1 ALO47182.1 ALO47217.1 ALO47217.1 ALO47292.1 ALO47292.1 ALO47315.1 ALO47315.1 ALO47570.1 ALO47570.1 ftsY ftsY ALO47622.1 ALO47622.1 yidC yidC PS2015_46 PS2015_46 secB secB PS2015_47 PS2015_47 ALO45156.1 ALO45156.1 ALO45158.1 ALO45158.1 ALO45161.1 ALO45161.1 ALO45162.1 ALO45162.1 ALO45163.1 ALO45163.1 ALO45164.1 ALO45164.1 ALO45165.1 ALO45165.1 PS2015_48 PS2015_48 ALO45166.1 ALO45166.1 ALO45167.1 ALO45167.1 PS2015_49 PS2015_49 tatC tatC tatB tatB PS2015_50 PS2015_50 tatA tatA PS2015_51 PS2015_51 PS2015_52 PS2015_52 PS2015_53 PS2015_53 ALO45218.1 ALO45218.1 PS2015_66 PS2015_66 PS2015_67 PS2015_67 ALO45365.1 ALO45365.1 ALO45368.1 ALO45368.1 ALO45373.1 ALO45373.1 ALO45374.1 ALO45374.1 ALO45376.1 ALO45376.1 ALO45377.1 ALO45377.1 ALO45398.1 ALO45398.1 ALO45435.1 ALO45435.1 ALO45454.1 ALO45454.1 ALO45624.1 ALO45624.1 ALO45654.1 ALO45654.1 ALO45655.1 ALO45655.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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yajCPreprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (109 aa)
secDPreprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (618 aa)
bamBOuter membrane protein assembly factor BamB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (371 aa)
ffhSignal recognition particle protein Ffh; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual comp [...] (460 aa)
ALO45916.1Outer membrane transport energization protein TonB; Pfam:pfam03544 Gram-negative bacterial TonB protein C-terminal. (124 aa)
secD-2Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (770 aa)
bamAOuter membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (903 aa)
ALO46046.1Pfam:pfam03938 Outer membrane protein (OmpH-like). (169 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (463 aa)
ALO46153.1Pfam:pfam01618 MotA/TolQ/ExbB proton channel family. (466 aa)
ALO46154.1Biopolymer transporter ExbB; Pfam:pfam01618 MotA/TolQ/ExbB proton channel family. (173 aa)
ALO46155.1Pfam:pfam02472 Biopolymer transport protein ExbD/TolR. (136 aa)
ALO46156.1Hypothetical protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (202 aa)
lolAHypothetical protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (237 aa)
ALO46226.1Hypothetical protein. (235 aa)
ALO46325.1Flagellar biosynthesis regulator FlhF; Pfam:pfam00448 SRP54-type protein, GTPase domain. (382 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (711 aa)
flhBFlagellar biosynthesis protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (380 aa)
ALO46328.1Flagellar biosynthetic protein fliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (257 aa)
fliQFlagellar biosynthesis protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliPFlagellar biosynthesis protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (267 aa)
ALO46336.1Pfam:pfam02050 Flagellar FliJ protein. (149 aa)
ALO46337.1Pfam:pfam00006 ATP synthase alpha/beta family, nucleotide-binding domain. (488 aa)
ALO46465.1Pfam:pfam02472 Biopolymer transport protein ExbD/TolR. (144 aa)
ALO46466.1Biopolymer transporter ExbB; Pfam:pfam01618 MotA/TolQ/ExbB proton channel family. (234 aa)
ALO46468.1Multidrug ABC transporter substrate-binding protein; Pfam:pfam12704 MacB-like periplasmic core domain. (422 aa)
lolDLipoprotein-releasing system ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (231 aa)
ALO46470.1Multidrug ABC transporter substrate-binding protein; Pfam:pfam12704 MacB-like periplasmic core domain. (413 aa)
ALO46557.1Hypothetical protein. (360 aa)
tolBTranslocation protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (435 aa)
ALO46622.1TolA protein; Pfam:pfam13103 TonB C terminal. (275 aa)
tolRTol biopolymer transport system, TolR protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (144 aa)
tolQProtein tolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (230 aa)
bamDOuter membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (338 aa)
ALO46776.1Pfam:pfam12019 Type II transport protein GspH. (175 aa)
ALO46845.1Hypothetical protein; Pfam:pfam13437 HlyD family secretion protein. (417 aa)
ALO46915.1Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; Pfam:pfam00437 Type II/IV secretion system protein. (546 aa)
ALO46916.1Hypothetical protein; Pfam:pfam00482 Type II secretion system (T2SS), protein F. (400 aa)
secAProtein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (920 aa)
ALO46940.1Hypothetical protein; Pfam:pfam11739 Dicarboxylate transport. (562 aa)
ALO47022.1Hypothetical protein; Pfam:pfam01203 Type II secretion system (T2SS), protein N. (239 aa)
ALO47023.1Hypothetical protein; Pfam:pfam04612 Type II secretion system (T2SS), protein M. (168 aa)
ALO47024.1Hypothetical protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (406 aa)
ALO47025.1Hypothetical protein; Pfam:pfam03934 Type II secretion system (T2SS), protein K. (354 aa)
ALO47026.1Hypothetical protein; Pfam:pfam11612 Type II secretion system (T2SS), protein J. (233 aa)
ALO47027.1Pfam:pfam02501 Type II secretion system (T2SS), protein I. (126 aa)
ALO47028.1Pfam:pfam12019 Type II transport protein GspH. (173 aa)
ALO47029.1Pfam:pfam08334 Type II secretion system (T2SS), protein G. (147 aa)
ALO47030.1General secretion pathway protein GspF; Pfam:pfam00482 Type II secretion system (T2SS), protein F. (407 aa)
ALO47031.1Hypothetical protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (487 aa)
ALO47032.1General secretion pathway protein GspD; Pfam:pfam00263 Bacterial type II and III secretion system protein. (652 aa)
ALO47033.1Hypothetical protein; Pfam:pfam11356 Type IV pilus biogenesis. (265 aa)
ALO47035.1Putative lipoprotein. (548 aa)
secYProtein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (440 aa)
secEProtein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (122 aa)
bamEOuter membrane protein assembly factor BamE; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (141 aa)
ALO44943.1Hypothetical protein. (80 aa)
ALO47182.1Membrane protein; Pfam:pfam01914 MarC family integral membrane protein. (195 aa)
ALO47217.1Pfam:pfam00005 ABC transporter. (246 aa)
ALO47292.1Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (123 aa)
ALO47315.1Fimbrial type-IV assembly protein, outer membran secretin; Pfam:pfam00263 Bacterial type II and III secretion system protein; Belongs to the bacterial secretin family. (410 aa)
ALO47570.1Membrane protein. (282 aa)
ftsYSignal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (333 aa)
ALO47622.1Preprotein translocase subunit SecA; Belongs to the UPF0225 family. (137 aa)
yidCMembrane protein insertase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (564 aa)
PS2015_46Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; Pfam:pfam00437 Type II/IV secretion system protein. (490 aa)
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (166 aa)
PS2015_47Type II secretory pathway, component PulF; Pfam:pfam00482 Type II secretion system (T2SS), protein F. (403 aa)
ALO45156.1Hypothetical protein. (233 aa)
ALO45158.1Hypothetical protein; Pfam:pfam00263 Bacterial type II and III secretion system protein. (628 aa)
ALO45161.1Pfam:pfam00437 Type II/IV secretion system protein. (612 aa)
ALO45162.1MSHA biogenesis protein MshG; Pfam:pfam00482 Type II secretion system (T2SS), protein F. (435 aa)
ALO45163.1Hypothetical protein. (192 aa)
ALO45164.1Pilin. (212 aa)
ALO45165.1Hypothetical protein. (183 aa)
PS2015_48Hypothetical protein; Pfam:pfam00263 Bacterial type II and III secretion system protein. (718 aa)
ALO45166.1Putative MSHA pilin protein MshD. (195 aa)
ALO45167.1Hypothetical protein. (276 aa)
PS2015_49General secretion pathway protein GspG; Pfam:pfam08334 Type II secretion system (T2SS), protein G. (131 aa)
tatCTwin-arginine translocation protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (253 aa)
tatBSec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (211 aa)
PS2015_50Hypothetical protein. (123 aa)
tatASec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (81 aa)
PS2015_51Hypothetical protein. (124 aa)
PS2015_52Hypothetical protein. (215 aa)
PS2015_53Hypothetical protein; Pfam:pfam03934 Type II secretion system (T2SS), protein K. (362 aa)
ALO45218.1ABC transporter, ATP-binding protein; Pfam:pfam00005 ABC transporter. (227 aa)
PS2015_66Pfam:pfam00529 HlyD family secretion protein. (434 aa)
PS2015_67Peptidase; Pfam:pfam00005 ABC transporter. (587 aa)
ALO45365.1Hypothetical protein. (223 aa)
ALO45368.1Hypothetical protein. (255 aa)
ALO45373.1Pfam:pfam00482 Type II secretion system (T2SS), protein F. (401 aa)
ALO45374.1Pfam:pfam00437 Type II/IV secretion system protein. (569 aa)
ALO45376.1MSHA-type pilus biogenesis protein MshL; Pfam:pfam00263 Bacterial type II and III secretion system protein; Belongs to the bacterial secretin family. (558 aa)
ALO45377.1Sporulation domain protein; Pfam:pfam13401 AAA domain. (424 aa)
ALO45398.1ABC transporter, ATP-binding protein; Pfam:pfam00005 ABC transporter. (238 aa)
ALO45435.1Hypothetical protein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (196 aa)
ALO45454.1Pfam:pfam02472 Biopolymer transport protein ExbD/TolR. (137 aa)
ALO45624.1Peptide ABC transporter; Pfam:pfam00854 POT family. (568 aa)
ALO45654.1Hypothetical protein; Pfam:pfam04357 Family of unknown function (DUF490). (1240 aa)
ALO45655.1Hypothetical protein; Pfam:pfam01103 Surface antigen. (611 aa)
Your Current Organism:
Pseudohongiella spirulinae
NCBI taxonomy Id: 1249552
Other names: KCTC 32221, LMG 27470, LMG:27470, Nonhongiella spirulinensis, P. spirulinae, Pseudohongiella spirulinae corrig. Wang et al. 2015, gamma proteobacterium Ma-20, strain Ma-20
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