45 items (Acanthamoeba castellanii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ACA1_396540	Actinrelated protein 3, putative; Belongs to the actin family. (428 aa)
	ACA1_138980	Dynamin family protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (822 aa)
	ACA1_216190	Protein kinase domain containing protein. (515 aa)
	ACA1_215490	Serine/threonine protein kinase 6, putative. (289 aa)
	ACA1_178580	F-box domain containing protein. (385 aa)
	ACA1_217590	B2-adapt-app_C domain-containing protein. (166 aa)
	ACA1_193160	RasGEF domain containing protein. (1027 aa)
	ACA1_051870	Serine/threonine kinase 24, putative. (457 aa)
	ACA1_380800	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (143 aa)
	ACA1_363740	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (200 aa)
	ACA1_097980	SAM domain (Sterile alpha motif) domain containing protein. (165 aa)
	ACA1_091710	PAS domain Sbox domain containing protein. (662 aa)
	ACA1_098000	SAM domain (Sterile alpha motif) domain containing protein. (1209 aa)
	ACA1_238390	Coronin; Belongs to the WD repeat coronin family. (394 aa)
	ACA1_261040	Uncharacterized protein. (662 aa)
	ACA1_373890	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (361 aa)
	ACA1_260020	Coronin; Belongs to the WD repeat coronin family. (453 aa)
	ACA1_160880	Clathrin adaptor complex small chain subfamily protein. (202 aa)
	ACA1_160760	Clathrin coat assembly protein AP50, putative. (159 aa)
	ACA1_145570	C2 domain-containing protein. (714 aa)
	ACA1_296900	Uncharacterized protein. (433 aa)
	ACA1_287560	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	ACA1_175620	IQGAPrelated protein. (947 aa)
	ACA1_175160	Alpha/beta hydrolase fold domain containing protein. (597 aa)
	ACA1_357610	RasGEF domain containing protein. (526 aa)
	ACA1_164150	Alpha/beta hydrolase fold domain containing protein. (847 aa)
	ACA1_360630	PH domain containing protein. (373 aa)
	ACA1_360140	Dynamin family protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	ACA1_034720	C2 domain containing protein. (648 aa)
	ACA1_302810	P21activated protein kinase PakA, putative. (406 aa)
	ACA1_027620	Aurora kinase A, putative. (267 aa)
	ACA1_268540	RasGEF domain containing protein. (640 aa)
	ACA1_112130	Regulator of g protein signaling domain containing protein. (982 aa)
	ACA1_198430	RasGEF domain containing protein. (829 aa)
	ACA1_323480	Dynamin gtpase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (679 aa)
	ACA1_167070	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1716 aa)
	ACA1_394620	RasGEF domain containing protein. (1213 aa)
	ACA1_064250	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (1055 aa)
	ACA1_248580	Alpha/beta hydrolase fold domain containing protein. (863 aa)
	ACA1_119270	Raclike protein. (221 aa)
	ACA1_296890	Dynamin domain containing protein. (1263 aa)
	ACA1_326740	Myosin2 heavy chain, non muscle, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1509 aa)
	ACA1_247120	K+ channel tetramerisation subfamily protein. (442 aa)
	ACA1_381550	K+ channel tetramerisation subfamily protein. (333 aa)
	ACA1_217370	Adaptorrelated protein complex 1, beta 1 subunit, isoform 2, putative. (857 aa)

Your Current Organism:

Acanthamoeba castellanii

NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACA1_064250	ACA1_138980	L8GZW9	L8GQ16	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Dynamin family protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.502
ACA1_064250	ACA1_160760	L8GZW9	L8GD72	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin coat assembly protein AP50, putative.	0.974
ACA1_064250	ACA1_160880	L8GZW9	L8GDI8	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin adaptor complex small chain subfamily protein.	0.982
ACA1_064250	ACA1_167070	L8GZW9	L8H0U7	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.895
ACA1_064250	ACA1_217370	L8GZW9	L8GPS7	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Adaptorrelated protein complex 1, beta 1 subunit, isoform 2, putative.	0.962
ACA1_064250	ACA1_217590	L8GZW9	L8GST3	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	B2-adapt-app_C domain-containing protein.	0.962
ACA1_064250	ACA1_261040	L8GZW9	L8GHN7	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein.	0.895
ACA1_064250	ACA1_287560	L8GZW9	L8HIN1	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.996
ACA1_064250	ACA1_296890	L8GZW9	L8HLM2	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Dynamin domain containing protein.	0.502
ACA1_064250	ACA1_323480	L8GZW9	L8H0X1	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Dynamin gtpase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.502
ACA1_064250	ACA1_360140	L8GZW9	L8HBU1	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Dynamin family protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.502
ACA1_064250	ACA1_363740	L8GZW9	L8GM18	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.951
ACA1_064250	ACA1_380800	L8GZW9	L8GP22	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.996
ACA1_091710	ACA1_119270	L8GKF5	L8HJ94	PAS domain Sbox domain containing protein.	Raclike protein.	0.408
ACA1_097980	ACA1_119270	L8GLP3	L8HJ94	SAM domain (Sterile alpha motif) domain containing protein.	Raclike protein.	0.408
ACA1_119270	ACA1_091710	L8HJ94	L8GKF5	Raclike protein.	PAS domain Sbox domain containing protein.	0.408
ACA1_119270	ACA1_097980	L8HJ94	L8GLP3	Raclike protein.	SAM domain (Sterile alpha motif) domain containing protein.	0.408
ACA1_138980	ACA1_064250	L8GQ16	L8GZW9	Dynamin family protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.502
ACA1_138980	ACA1_167070	L8GQ16	L8H0U7	Dynamin family protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.534
ACA1_138980	ACA1_217370	L8GQ16	L8GPS7	Dynamin family protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Adaptorrelated protein complex 1, beta 1 subunit, isoform 2, putative.	0.423

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