STRINGSTRING
ACA1_351280 ACA1_351280 ACA1_127610 ACA1_127610 ACA1_136190 ACA1_136190 ACA1_100930 ACA1_100930 ACA1_258010 ACA1_258010 ACA1_374060 ACA1_374060 ACA1_243850 ACA1_243850 ACA1_349800 ACA1_349800 ACA1_246830 ACA1_246830 ACA1_349820 ACA1_349820 ACA1_076810 ACA1_076810 ACA1_193120 ACA1_193120 ACA1_129950 ACA1_129950 ACA1_051440 ACA1_051440 ACA1_377340 ACA1_377340 ACA1_188580 ACA1_188580 ACA1_178740 ACA1_178740 ACA1_001870 ACA1_001870 ACA1_061390 ACA1_061390 ACA1_058830 ACA1_058830 ACA1_061400 ACA1_061400 ACA1_062270 ACA1_062270 ACA1_248410 ACA1_248410 ACA1_368210 ACA1_368210 ACA1_208210 ACA1_208210 ACA1_015510 ACA1_015510 ACA1_045630 ACA1_045630 ACA1_300490 ACA1_300490 ACA1_394580 ACA1_394580 ACA1_201650 ACA1_201650 ACA1_265860 ACA1_265860 ACA1_198280 ACA1_198280 ACA1_117110 ACA1_117110 ACA1_012990 ACA1_012990 ACA1_280590 ACA1_280590 ACA1_282350 ACA1_282350 ACA1_251050 ACA1_251050 ACA1_331590 ACA1_331590 ACA1_071890 ACA1_071890 ACA1_072340 ACA1_072340 ACA1_153540 ACA1_153540 ACA1_170660 ACA1_170660 ACA1_288350 ACA1_288350 ACA1_170670 ACA1_170670 ACA1_004200 ACA1_004200 ACA1_288560 ACA1_288560 ACA1_296520 ACA1_296520 ACA1_288660 ACA1_288660 ACA1_296330 ACA1_296330 ACA1_110350 ACA1_110350 ACA1_174470 ACA1_174470 ACA1_018990 ACA1_018990 ACA1_309810 ACA1_309810 ACA1_289970 ACA1_289970 ACA1_290800 ACA1_290800 ACA1_084880 ACA1_084880
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACA1_3512803'5' exonuclease domain containing protein. (223 aa)
ACA1_127610Core histone h2a/h2b/h3/h4 superfamily protein; Belongs to the histone H2B family. (1601 aa)
ACA1_136190SER_THR_PHOSPHATASE domain-containing protein. (293 aa)
ACA1_100930DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1105 aa)
ACA1_258010BRCA1 C Terminus (BRCT) domain containing protein. (383 aa)
ACA1_374060Rad51l1 protein. (248 aa)
ACA1_243850GTPase-activator protein for Ras family GTPase. (1182 aa)
ACA1_349800Timeless protein. (362 aa)
ACA1_246830ERCC4 domain containing protein. (936 aa)
ACA1_349820Uncharacterized protein. (643 aa)
ACA1_076810Transcriptional regulator, Sir2, putative. (411 aa)
ACA1_193120KxDL domain-containing protein. (275 aa)
ACA1_129950RECA_2 domain-containing protein. (480 aa)
ACA1_051440DNA replication helicase, putative. (848 aa)
ACA1_377340DNA replication factor Dna2. (1101 aa)
ACA1_188580DNA repair and recombination protein RAD52, putative. (278 aa)
ACA1_178740Replication protein A subunit. (553 aa)
ACA1_001870Histone cluster 1, H2bb, putative; Belongs to the histone H2B family. (105 aa)
ACA1_061390FATC domain containing protein; Belongs to the PI3/PI4-kinase family. (2990 aa)
ACA1_058830Uncharacterized protein. (193 aa)
ACA1_061400TAN domain-containing protein. (362 aa)
ACA1_062270Serine/threonine-protein phosphatase. (279 aa)
ACA1_248410Alpha2-macroglobulin domain containing protein. (2317 aa)
ACA1_368210DNA repair protein XRCC3, putative. (403 aa)
ACA1_208210Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (297 aa)
ACA1_015510Replication factora protein 1 (Rpa1) subfamily protein. (646 aa)
ACA1_045630NADHdependent histone deacetylase. (281 aa)
ACA1_300490KxDL domain-containing protein. (277 aa)
ACA1_3945803'5' exonuclease domain containing protein. (237 aa)
ACA1_201650DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (342 aa)
ACA1_265860Histone H2B; Belongs to the histone H2B family. (163 aa)
ACA1_198280RECA_2 domain-containing protein. (307 aa)
ACA1_117110Transcriptional regulator, Sir2 family protein. (377 aa)
ACA1_012990ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (608 aa)
ACA1_280590Poly(ADPribose) polymerase and DNA-Ligase Zn-finger region domain containing protein. (231 aa)
ACA1_282350ATPdependent DNA helicase, RecQ subfamily protein. (919 aa)
ACA1_251050Ser/Thr phosphatase family protein. (468 aa)
ACA1_331590ATPdependent DNA helicase, RecQ subfamily protein. (1067 aa)
ACA1_071890FHA domain containing protein. (509 aa)
ACA1_072340Serine/threonine-protein phosphatase. (449 aa)
ACA1_153540Transcriptional regulator, Sir2 family protein. (582 aa)
ACA1_170660UME domain-containing protein. (689 aa)
ACA1_288350Transcriptional regulator, Sir2 family protein. (388 aa)
ACA1_170670FRAP-related family protein. (583 aa)
ACA1_004200Serine-protein kinase ATR family protein; Belongs to the PI3/PI4-kinase family. (319 aa)
ACA1_288560ERCC4 domain containing protein. (728 aa)
ACA1_296520CUE domain containing protein. (542 aa)
ACA1_288660Uncharacterized protein. (276 aa)
ACA1_296330Serine/threonine-protein phosphatase. (307 aa)
ACA1_110350BRCA2 repeat-containing protein. (1827 aa)
ACA1_174470DUF1767 domain-containing protein. (708 aa)
ACA1_018990Subunit of DNA polymerase II. (1617 aa)
ACA1_309810Rad9 protein. (380 aa)
ACA1_289970FHA domain containing protein. (689 aa)
ACA1_290800SAP domain containing protein. (455 aa)
ACA1_084880Transcriptional regulator, Sir2 family protein. (536 aa)
Your Current Organism:
Acanthamoeba castellanii
NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.