74 items (Acanthamoeba castellanii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACA1_234760	WH1 domain containing protein. (478 aa)
	ACA1_279050	COP9 subunit 8, putative. (202 aa)
	ACA1_114450	SH3 domain containing protein. (513 aa)
	ACA1_278330	WH1 domain containing protein. (345 aa)
	ACA1_115410	LMBR1 domain containing protein. (614 aa)
	ACA1_279420	BAR domain containing protein. (300 aa)
	ACA1_183900	Phosphatidylinositol phosphate kinase PIPK5, putative. (707 aa)
	ACA1_181930	GRAM domain containing protein. (1479 aa)
	ACA1_277410	SH3 domain containing protein. (415 aa)
	ACA1_385490	SH3 domain containing protein. (822 aa)
	ACA1_181830	Phosphatidylinositol4 phosphate 5-kinase, putative. (1134 aa)
	ACA1_157590	Uncharacterized protein. (944 aa)
	ACA1_125940	Phosphatidylinositol-4-phosphate 5-Kinase. (775 aa)
	ACA1_331710	Autophagy-related protein 27 protein. (268 aa)
	ACA1_399180	IRSp53/MIM domain containing protein. (366 aa)
	ACA1_074760	Signalosome complex protein. (342 aa)
	ACA1_171230	Arf GTPase activating protein. (392 aa)
	ACA1_172100	Phosphatidylinositol4-phosphate 5-Kinase. (750 aa)
	ACA1_288500	PCI domain containing protein. (467 aa)
	ACA1_309800	Variant sh3 domain containing protein. (432 aa)
	ACA1_287240	WH1 domain containing protein. (194 aa)
	ACA1_287560	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	ACA1_356540	Protein serine/threonine kinase. (81 aa)
	ACA1_326770	SH3 domain containing protein. (497 aa)
	ACA1_173940	SH3 domain containing protein. (721 aa)
	ACA1_288290	SH3 domain containing protein. (483 aa)
	ACA1_119410	COP9, putative. (264 aa)
	ACA1_144830	C2 domain containing protein. (1251 aa)
	ACA1_160760	Clathrin coat assembly protein AP50, putative. (159 aa)
	ACA1_160880	Clathrin adaptor complex small chain subfamily protein. (202 aa)
	ACA1_160620	Autophagy-related protein 27 protein. (252 aa)
	ACA1_321190	Adaptin earbinding coat-associated protein 2 (NECAP-2) isoform 2, putative. (214 aa)
	ACA1_140060	ATPase family associated with various cellular activities (AAA) domain containing protein. (326 aa)
	ACA1_400570	Ubiquitin domain containing protein. (548 aa)
	ACA1_261040	Uncharacterized protein. (662 aa)
	ACA1_090960	Protein kinase; Belongs to the protein kinase superfamily. (360 aa)
	ACA1_096720	FYVE zinc finger domain containing protein. (703 aa)
	ACA1_140970	SH3 domain containing protein. (539 aa)
	ACA1_090950	ANTH domain-containing protein. (1056 aa)
	ACA1_093930	p21Rho-binding domain containing protein. (278 aa)
	ACA1_358660	SH3 domain containing protein. (669 aa)
	ACA1_120810	Phosphatidylinositol-4-phosphate 5-Kinase. (855 aa)
	ACA1_364490	Protein kinase domain containing protein. (678 aa)
	ACA1_363740	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (200 aa)
	ACA1_379980	SH3 domain containing protein. (539 aa)
	ACA1_193120	KxDL domain-containing protein. (275 aa)
	ACA1_130180	COP9 subunit, putative. (318 aa)
	ACA1_271370	Phosphatidylinositol4-phosphate 5-Kinase. (820 aa)
	ACA1_380800	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (143 aa)
	ACA1_215300	Phosphatidylinositol4-phosphate 5-Kinase protein. (863 aa)
	ACA1_217370	Adaptorrelated protein complex 1, beta 1 subunit, isoform 2, putative. (857 aa)
	ACA1_217590	B2-adapt-app_C domain-containing protein. (166 aa)
	ACA1_177890	Phosphatidylinositol4-phosphate 5-Kinase. (674 aa)
	ACA1_088920	Phorbol esters/diacylglycerol binding domain containing protein. (1319 aa)
	ACA1_188490	COP9 signalosome complex subunit 3 (Signalosome subunit 3), putative. (323 aa)
	ACA1_178750	PCI domain containing protein. (442 aa)
	ACA1_062260	C2 domain containing protein. (662 aa)
	ACA1_248410	Alpha2-macroglobulin domain containing protein. (2317 aa)
	ACA1_208610	AAA domain-containing protein. (394 aa)
	ACA1_063070	p21Rho-binding domain containing protein. (281 aa)
	ACA1_063970	SH3 domain containing protein. (552 aa)
	ACA1_369850	ATPase with chaperone activity, putative; Belongs to the ClpA/ClpB family. (785 aa)
	ACA1_064250	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (1055 aa)
	ACA1_167070	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1716 aa)
	ACA1_262530	SH3 domain containing protein. (315 aa)
	ACA1_300490	KxDL domain-containing protein. (277 aa)
	ACA1_044460	Uncharacterized protein. (400 aa)
	ACA1_200420	Autophagy-related protein 27 protein. (267 aa)
	ACA1_323500	p21Rho-binding domain containing protein. (422 aa)
	ACA1_112590	WH2 motif domain containing protein. (688 aa)
	ACA1_113780	COP9 signalosome subunit 6, putative. (314 aa)
	ACA1_113710	SH3 domain containing protein. (363 aa)
	ACA1_198570	COP9 signalosome complex subunit 4, putative. (391 aa)
	ACA1_055000	I/LWEQ domain containing protein. (649 aa)

Your Current Organism:

Acanthamoeba castellanii

NCBI taxonomy Id: 1257118
Other names: A. castellanii str. Neff, Acanthamoeba castellanii Neff strain, Acanthamoeba castellanii str. Neff, Acanthamoeba castellanii strain Neff

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACA1_055000	ACA1_064250	L8H5G7	L8GZW9	I/LWEQ domain containing protein.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.564
ACA1_055000	ACA1_090960	L8H5G7	L8GI25	I/LWEQ domain containing protein.	Protein kinase; Belongs to the protein kinase superfamily.	0.537
ACA1_055000	ACA1_160620	L8H5G7	L8GFX5	I/LWEQ domain containing protein.	Autophagy-related protein 27 protein.	0.490
ACA1_055000	ACA1_167070	L8H5G7	L8H0U7	I/LWEQ domain containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.836
ACA1_055000	ACA1_217370	L8H5G7	L8GPS7	I/LWEQ domain containing protein.	Adaptorrelated protein complex 1, beta 1 subunit, isoform 2, putative.	0.514
ACA1_055000	ACA1_217590	L8H5G7	L8GST3	I/LWEQ domain containing protein.	B2-adapt-app_C domain-containing protein.	0.514
ACA1_055000	ACA1_261040	L8H5G7	L8GHN7	I/LWEQ domain containing protein.	Uncharacterized protein.	0.836
ACA1_055000	ACA1_277410	L8H5G7	L8H7W0	I/LWEQ domain containing protein.	SH3 domain containing protein.	0.401
ACA1_055000	ACA1_279420	L8H5G7	L8H745	I/LWEQ domain containing protein.	BAR domain containing protein.	0.401
ACA1_055000	ACA1_309800	L8H5G7	L8HIA9	I/LWEQ domain containing protein.	Variant sh3 domain containing protein.	0.401
ACA1_055000	ACA1_321190	L8H5G7	L8GG94	I/LWEQ domain containing protein.	Adaptin earbinding coat-associated protein 2 (NECAP-2) isoform 2, putative.	0.614
ACA1_055000	ACA1_326770	L8H5G7	L8HJF3	I/LWEQ domain containing protein.	SH3 domain containing protein.	0.533
ACA1_055000	ACA1_331710	L8H5G7	L8HAW7	I/LWEQ domain containing protein.	Autophagy-related protein 27 protein.	0.490
ACA1_055000	ACA1_356540	L8H5G7	L8HIT6	I/LWEQ domain containing protein.	Protein serine/threonine kinase.	0.537
ACA1_055000	ACA1_363740	L8H5G7	L8GM18	I/LWEQ domain containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.924
ACA1_055000	ACA1_364490	L8H5G7	L8GLK8	I/LWEQ domain containing protein.	Protein kinase domain containing protein.	0.537
ACA1_055000	ACA1_385490	L8H5G7	L8H963	I/LWEQ domain containing protein.	SH3 domain containing protein.	0.401
ACA1_062260	ACA1_358660	L8GW88	L8GLJ2	C2 domain containing protein.	SH3 domain containing protein.	0.675
ACA1_063070	ACA1_114450	L8GYC7	L8H6I9	p21Rho-binding domain containing protein.	SH3 domain containing protein.	0.476
ACA1_063070	ACA1_167070	L8GYC7	L8H0U7	p21Rho-binding domain containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.426

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