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| | murA | uDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (426 aa) |
| | CDE27640.1 | relA/SpoT domain protein; Product inferred by homology to UniProt. (268 aa) |
| | CDE27610.1 | Uncharacterized protein; Product inferred by homology to UniProt. (175 aa) |
| | CDE27601.1 | Type III pantothenate kinase; Product inferred by homology to UniProt. (71 aa) |
| | ackA-2 | Acetate kinase 1; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | CDE28250.1 | gTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (738 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Product inferred by homology to UniProt; Belongs to the CarB family. (1065 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Product inferred by homology to UniProt; Belongs to the CarA family. (355 aa) |
| | pyrG | cTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (306 aa) |
| | pyrK | Dihydroorotate dehydrogenase B (NAD(+)) electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (252 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (421 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | CDE28182.1 | uDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2 6-diaminopimelate ligase; Product inferred by homology to UniProt; Belongs to the MurCDEF family. MurE subfamily. (492 aa) |
| | CDE28176.1 | relA/SpoT domain protein; Product inferred by homology to UniProt. (242 aa) |
| | pyrB | Aspartate carbamoyltransferase; Product inferred by homology to UniProt; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) |
| | CDE28080.1 | Uncharacterized protein; Product inferred by homology to UniProt. (197 aa) |
| | CDE28078.1 | Anaerobic ribonucleoside-triphosphate reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (168 aa) |
| | CDE28071.1 | Uncharacterized protein; Product inferred by homology to UniProt. (247 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | glmU | Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (465 aa) |
| | CDE28002.1 | O-antigen polymerase; Product inferred by homology to UniProt. (398 aa) |
| | CDE27949.1 | Adenylosuccinate lyase; Product inferred by homology to UniProt; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (459 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Product inferred by homology to UniProt; Belongs to the GARS family. (416 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH; Product inferred by homology to UniProt. (507 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (196 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Product inferred by homology to UniProt. (341 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Product inferred by homology to UniProt; Belongs to the SAICAR synthetase family. (235 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | uppP | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (280 aa) |
| | dacA | tIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (266 aa) |
| | murF | uDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (447 aa) |
| | ddl | d-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (342 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (473 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (399 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (623 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | CDE28992.1 | erfK/YbiS/YcfS/YnhG; Product inferred by homology to UniProt. (667 aa) |
| | ackA | Acetate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa) |
| | CDE28906.1 | Uncharacterized protein; Product inferred by homology to UniProt. (258 aa) |
| | CDE28462.1 | cDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase; Product inferred by homology to UniProt. (365 aa) |
| | CDE28461.1 | cDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase; Product inferred by homology to UniProt. (397 aa) |
| | CDE28460.1 | Glycosyltransferase group 2 family protein; Product inferred by homology to UniProt. (744 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (212 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (234 aa) |
| | CDE28440.1 | Serine-type D-Ala-D-Ala carboxypeptidase; Product inferred by homology to UniProt; Belongs to the peptidase S11 family. (305 aa) |
| | CDE28136.1 | Inosine 5-monophosphate dehydrogenase; Product inferred by homology to UniProt. (502 aa) |
| | CDE27962.1 | pAP2 family protein; Product inferred by homology to UniProt. (190 aa) |
| | atpD-2 | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (211 aa) |
| | atpB | V-type ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (482 aa) |
| | atpA-2 | V-type ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (583 aa) |
| | CDE27523.1 | Putative ATP synthase subunit E; Product inferred by homology to UniProt. (196 aa) |
| | CDE27521.1 | Putative V-type sodium ATPase K subunit; Product inferred by homology to UniProt. (144 aa) |
| | CDE27509.1 | Uncharacterized protein; Product inferred by homology to UniProt. (84 aa) |
| | CDE27483.1 | Uncharacterized protein; Product inferred by homology to UniProt. (260 aa) |
| | CDE27447.1 | Hypoxanthine phosphoribosyltransferase; Product inferred by homology to UniProt; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | CDE27421.1 | pAP2 family protein; Product inferred by homology to UniProt. (157 aa) |
| | CDE27410.1 | erfK/YbiS/YcfS/YnhG; Product inferred by homology to UniProt. (487 aa) |
| | murE | uDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (489 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (255 aa) |
| | CDE27152.1 | ser/Thr phosphatase family protein; Product inferred by homology to UniProt. (265 aa) |
| | CDE27077.1 | Uncharacterized protein; Product inferred by homology to UniProt. (108 aa) |
| | atpC | aTP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa) |
| | atpD | aTP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (466 aa) |
| | atpG | aTP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (284 aa) |
| | atpA | aTP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (508 aa) |
| | atpH | aTP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa) |
| | atpF | aTP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (166 aa) |
| | atpE | aTP synthase F0 C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | CDE27032.1 | aTP synthase subunit a; Product inferred by homology to UniProt. (221 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (206 aa) |
| | CDE29055.1 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (346 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (599 aa) |
| | udk | Uridine kinase; Product inferred by homology to UniProt. (208 aa) |
| | mltG | yceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (343 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; Product inferred by homology to UniProt; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (485 aa) |
| | CDE28947.1 | ser/Thr phosphatase family protein; Product inferred by homology to UniProt. (319 aa) |
| | murB-2 | uDP-N-acetylenolpyruvoylglucosamine reductase 2; Cell wall formation. (331 aa) |
| | CDE28939.1 | aICARFT/IMPCHase bienzyme; Product inferred by homology to UniProt. (392 aa) |
| | CDE28922.1 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (162 aa) |
| | CDE28859.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (394 aa) |
| | CDE28848.1 | N-acetylglucosaminylphosphatidylinositol deacetylase; Product inferred by homology to UniProt. (223 aa) |
| | CDE28706.1 | Putative UDP-N-acetylmuramate--L-alanine ligase; Product inferred by homology to UniProt. (436 aa) |
| | CDE28699.1 | Riboflavin biosynthesis protein RibF; Product inferred by homology to UniProt; Belongs to the ribF family. (309 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (292 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (190 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (422 aa) |
| | guaA | gMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (514 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (142 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (312 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (286 aa) |
| | CDE28484.1 | acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (377 aa) |
| | queA | s-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (348 aa) |
| | queH | Uncharacterized protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (209 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (322 aa) |
| | murD | uDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (446 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (362 aa) |
| | murB | uDP-N-acetylenolpyruvoylglucosamine reductase 1; Cell wall formation. (303 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (204 aa) |
