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| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (877 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | odhB | Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (408 aa) |
| | sucA | 2-oxoglutarate dehydrogenase E1 component PRK09404; 2-oxoglutarate dehydrogenase E1 component of Gammaproteobacteria UniRef RepID=ODO1_HAEIN. (935 aa) |
| | AHG83880.1 | L-serine dehydratase TdcG PRK15040; L-serine dehydratase of root UniRef RepID=SDHL_HAEIN; Belongs to the iron-sulfur dependent L-serine dehydratase family. (459 aa) |
| | AHG83907.1 | 5,10-methylenetetrahydrofolate reductase PRK09432; 5,10-methylenetetrahydrofolate reductase of Proteobacteria UniRef RepID=METF_PECCC; Belongs to the methylenetetrahydrofolate reductase family. (294 aa) |
| | AHG83917.1 | Isocitrate dehydrogenase PRK07006; Isocitrate dehydrogenase [NADP] of Gammaproteobacteria UniRef RepID=B7UV18_PSEA8. (415 aa) |
| | acnB | Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase PRK09238; Aconitate hydratase 2 of cellular organisms UniRef RepID=ACON2_PSEAE; Belongs to the aconitase/IPM isomerase family. (867 aa) |
| | AHG83919.1 | Type II citrate synthase PRK05614; Citrate synthase I of Bacteria UniRef RepID=E3I1M6_RHOVT; Belongs to the citrate synthase family. (426 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | AHG83943.1 | Cystathionine gamma-synthase PRK08247; Cystathionine gamma-synthase of Bacteria UniRef RepID=METB_HAEIN. (372 aa) |
| | AHG83956.1 | Aromatic amino acid aminotransferase PRK09257; Aspartate aminotransferase of Proteobacteria UniRef RepID=AAT_HAEIN. (398 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (341 aa) |
| | glyA | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa) |
| | AHG83965.1 | Phosphoglycerate mutase of Pasteurellaceae UniRef RepID=B0BSN7_ACTPJ. (208 aa) |
| | AHG83966.1 | Pseudouridine synthase of Proteobacteria UniRef RepID=A3MYV1_ACTP2. (214 aa) |
| | glpX | Fructose-1,6-bisphosphatase class 2; Fructose 1,6-bisphosphatase II PRK09479; Fructose-1,6-bisphosphatase class 2 of Bacteria UniRef RepID=GLPX_HAEIN. (339 aa) |
| | cysS | cysteinyl-tRNA synthetase PRK00260; Cysteinyl-tRNA synthetase of Gammaproteobacteria UniRef RepID=E0WSA9_9ENTR; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa) |
| | ilvN | Acetolactate synthase 3 regulatory subunit PRK11895; Acetolactate synthase small subunit of root UniRef RepID=ILVH_HAEIN. (163 aa) |
| | AHG84006.1 | Acetolactate synthase 3 catalytic subunit PRK06882; Acetolactate synthase isozyme 3 large subunit of Proteobacteria UniRef RepID=ILVI_ECOLI. (573 aa) |
| | AHG84007.1 | Bifunctional malic enzyme oxidoreductase/phosphotransacetylase PRK07232; NADP-dependent malic enzyme of Bacteria UniRef RepID=MAO2_SALTY. (757 aa) |
| | AHG84046.1 | Methionine synthase; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase PRK09121; Methionine synthase (B12-independent) of Bacteria UniRef RepID=Q07X59_SHEFN. (343 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (365 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (360 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (536 aa) |
| | AHG84072.1 | Asparaginase of Lactobacillales UniRef RepID=Q03PH2_LACBA. (321 aa) |
| | aceE | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | AHG84074.1 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (529 aa) |
| | AHG84075.1 | Pyruvate dehydrogenase dihydrolipoyltransacetylase PRK11854; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex of Pasteurellaceae UniRef RepID=ODP2_HAEIN. (104 aa) |
| | AHG84076.1 | Dihydrolipoamide dehydrogenase PRK06467; Dihydrolipoyl dehydrogenase of cellular organisms UniRef RepID=DLDH_HAEIN; overlaps CDS with the same product name. (263 aa) |
| | lpdA | Dihydrolipoamide dehydrogenase PRK06467; Dihydrolipoyl dehydrogenase of cellular organisms UniRef RepID=DLDH_HAEIN; overlaps CDS with the same product name. (241 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa) |
| | AHG84095.1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (711 aa) |
| | dld | D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (564 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (431 aa) |
| | hisC | Histidinol-phosphate aminotransferase PRK02731; Histidinol-phosphate aminotransferase 1 of Proteobacteria UniRef RepID=HIS81_MANSM; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | lysC | Aspartate kinase III PRK09084; Lysine-sensitive aspartokinase 3 of Bacteria UniRef RepID=AK3_ECOLI; Belongs to the aspartokinase family. (450 aa) |
| | AHG84189.1 | Glutamate dehydrogenase PRK09414; Glutamate dehydrogenase of Proteobacteria UniRef RepID=Q46UV2_CUPPJ; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (449 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (367 aa) |
| | AHG84194.1 | Hypothetical protein; KLLA0D19929p of cellular organisms UniRef RepID=B5FV81_KLULA. (232 aa) |
| | AHG84195.1 | Hypothetical protein; KLLA0D19929p of cellular organisms UniRef RepID=B5FV81_KLULA. (85 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | accD | Acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (298 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | AHG84270.1 | Multifunctional fatty acid oxidation complex subunit alpha PRK11154; Fatty oxidation complex, alpha subunit of Haemophilus parasuis UniRef RepID=B8F4S2_HAEPS; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa) |
| | AHG84271.1 | 3-ketoacyl-CoA thiolase PRK08963; Acetyl-CoA acetyltransferase of Pasteurellaceae UniRef RepID=B0BPH2_ACTPJ; Belongs to the thiolase-like superfamily. Thiolase family. (434 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (362 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (227 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (390 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit-like protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa) |
| | leuD | 3-isopropylmalate dehydratase large subunit-like protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (219 aa) |
| | glsA | Glutaminase PRK00971; Glutaminase of Bacteroidetes UniRef RepID=A3U907_CROAH; Belongs to the glutaminase family. (305 aa) |
| | trpF | Tryptophan biosynthesis protein TrpCF; Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase PRK09427; Tryptophan biosynthesis protein TrpCF of Gammaproteobacteria UniRef RepID=TRPC_HAEIN. (471 aa) |
| | AHG84361.1 | GntP family transporter; H+/gluconate symporter and permeases COG2610; GntP family transporter of Bacteria UniRef RepID=Q4FRS9_PSYA2. (462 aa) |
| | AHG84362.1 | 3-hydroxybutyrate dehydrogenase PRK12429; D-beta-hydroxybutyrate dehydrogenase of Bacteria UniRef RepID=Q08MV7_STIAD. (252 aa) |
| | AHG84363.1 | Acyltransferase PRK05790; Acetyl-CoA acetyltransferase of cellular organisms UniRef RepID=THIL_CUPNH; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | AHG84364.1 | Short-chain fatty acids transporter of Bacteria UniRef RepID=ATOE_HAEIN. (447 aa) |
| | AHG84365.1 | Acetate CoA-transferase subunit beta of Bacteria UniRef RepID=ATOA_HAEIN. (219 aa) |
| | AHG84366.1 | acetyl-CoA:acetoacetyl-CoA transferase subunit alpha PRK09920; Acetate CoA-transferase subunit alpha of Bacteria UniRef RepID=ATOD_HAEIN. (215 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (321 aa) |
| | AHG84429.1 | Aminoacyl-histidine dipeptidase of Gammaproteobacteria UniRef RepID=B0BSQ9_ACTPJ. (484 aa) |
| | AHG84470.1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | pgk | Phosphoglycerate kinase PRK00073; Phosphoglycerate kinase of Aggregatibacter actinomycetemcomitans UniRef RepID=G4ACN5_AGGAC; Belongs to the phosphoglycerate kinase family. (385 aa) |
| | AHG84519.1 | Inositol-1-monophosphatase; Inositol monophosphatase PRK10757; Inositol-1-monophosphatase of Bacteria UniRef RepID=SUHB_PASMU. (269 aa) |
| | AHG84528.1 | Hypothetical protein; UPI00021ACE07 cluster of unknown UniRef RepID=UPI00021ACE07. (261 aa) |
| | yjjI | Uncharacterized protein HI_0521 of Bacteria UniRef RepID=Y521_HAEIN. (509 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (314 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa) |
| | argD | Acetylornithine aminotransferase PRK02627; Acetylornithine aminotransferase of Haemophilus ducreyi 35000HP UniRef RepID=ARGD_HAEDU; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (314 aa) |
| | AHG84579.1 | Acylphosphatase PRK14448; Acylphosphatase of Aggregatibacter actinomycetemcomitans UniRef RepID=C9R5C3_AGGAD. (114 aa) |
| | AHG84608.1 | Aminotransferase AlaT PRK09265; Aminotransferase AlaT of Bacteria UniRef RepID=B8F699_HAEPS. (405 aa) |
| | pheA | Bifunctional chorismate mutase/prephenate dehydratase PRK10622; Bifunctional prephenate dehydratase/chorismate mutase of Gammaproteobacteria UniRef RepID=B8F6C2_HAEPS. (385 aa) |
| | sucD | Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa) |
| | sucC | Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | AHG84630.1 | Bifunctional acetaldehyde-CoA/alcohol dehydrogenase PRK13805; Iron-containing alcohol dehydrogenase of Bacteria UniRef RepID=C7QZE3_JONDD; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (896 aa) |
| | AHG84631.1 | Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (245 aa) |
| | pflB | Formate acetyltransferase of cellular organisms UniRef RepID=PFLB_HAEIN. (774 aa) |
| | AHG84636.1 | Hypothetical protein; Formate hydrogenlyase subunit 4 COG0650; uncharacterized protein of Pasteurella UniRef RepID=C9PPZ9_9PAST. (129 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase CysQ; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (272 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa) |
| | pgl | Hypothetical protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (236 aa) |
| | AHG84640.1 | Uncharacterized protein of Pasteurellaceae UniRef RepID=Q9CKQ4_PASMU. (121 aa) |
| | gnd | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa) |
| | AHG84642.1 | Uncharacterized protein of Methylophaga aminisulfidivorans MP UniRef RepID=F5SWY5_9GAMM. (112 aa) |
| | argH | Argininosuccinate lyase PRK04833; Argininosuccinate lyase of cellular organisms UniRef RepID=ARLY_TOLAT. (472 aa) |
| | AHG84657.1 | Aminopeptidase N PRK14015; Aminopeptidase N of Gammaproteobacteria UniRef RepID=AMPN_HAEIN. (869 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (756 aa) |
| | ilvD | Dihydroxy-acid dehydratase PRK12448; Dihydroxy-acid dehydratase of Bacteria UniRef RepID=D8IY91_HERSS; Belongs to the IlvD/Edd family. (597 aa) |
| | fbp | Fructose-1,6-bisphosphatase PRK09293; Fructose-1,6-bisphosphatase class 1 of Bacteria UniRef RepID=F16PA_PROMH; Belongs to the FBPase class 1 family. (333 aa) |
| | AHG84725.1 | Serine acetyltransferase PRK11132; Serine acetyltransferase of cellular organisms UniRef RepID=B4F141_PROMH; overlaps CDS with the same product name. (233 aa) |
| | hisI | Histidine biosynthesis bifunctional protein HisIE; Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein PRK02759; Histidine biosynthesis bifunctional protein HisIE of Bacteria UniRef RepID=HIS2_HAEIN; In the N-terminal section; belongs to the PRA-CH family. (212 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase PRK00748; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase of Bacteria UniRef RepID=HIS4_ACTP2. (249 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa) |
| | hisB | Histidine biosynthesis bifunctional protein hisB; Imidazole glycerol-phosphate dehydratase/histidinol phosphatase PRK05446; Histidine biosynthesis bifunctional protein hisB of Bacteria UniRef RepID=HIS7_ACTSZ; In the N-terminal section; belongs to the histidinol- phosphatase family. (362 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase PRK01688; Histidinol-phosphate aminotransferase of Bacteria UniRef RepID=HIS8_YERE8; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (353 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (298 aa) |
| | AHG84777.1 | IMPACT family member HI_0722 of Bacteria UniRef RepID=Y722_HAEIN. (208 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | AHG84788.1 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (155 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase PRK11830; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase of root UniRef RepID=DAPD_NEIG1; Belongs to the transferase hexapeptide repeat family. (291 aa) |
| | cysK | Cysteine synthase A PRK10717; Cysteine synthase of Bacteria UniRef RepID=Q482P1_COLP3; Belongs to the cysteine synthase/cystathionine beta- synthase family. (316 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (230 aa) |
| | AHG84862.1 | D-3-phosphoglycerate dehydrogenase PRK11790; D-3-phosphoglycerate dehydrogenase of Bacteria UniRef RepID=SERA_HAEIN; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa) |
| | tal | Transaldolase 1; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (401 aa) |
| | AHG84897.1 | Fumarate reductase flavoprotein subunit PRK09231; Fumarate reductase flavoprotein subunit of cellular organisms UniRef RepID=FRDA_HAEIN. (596 aa) |
| | AHG84898.1 | Fumarate reductase iron-sulfur subunit PRK12385; Fumarate reductase iron-sulfur subunit of Proteobacteria UniRef RepID=FRDB_HAEIN; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (255 aa) |
| | frdC | Reductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (129 aa) |
| | frdD | Reductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (114 aa) |
| | asnA | Aspartate--ammonia ligase; Asparagine synthetase AsnA PRK05425; Aspartate--ammonia ligase of cellular organisms UniRef RepID=ASNA_HAEIE. (330 aa) |
| | AHG84944.1 | Glycerate kinase of Bacteria UniRef RepID=B0US17_HAES2; Belongs to the glycerate kinase type-1 family. (378 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (414 aa) |
| | AHG85000.1 | D-isomer specific 2-hydroxyacid dehydrogenase family protein of Proteobacteria UniRef RepID=Q4KE06_PSEF5. (352 aa) |
| | AHG85007.1 | Anaerobic C4-dicarboxylate transporter DcuA; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. (435 aa) |
| | AHG85008.1 | Aspartate racemase COG1794; Possible aspartate racemase of Pasteurellaceae UniRef RepID=A7JW07_PASHA; Belongs to the aspartate/glutamate racemases family. (231 aa) |
| | AHG85043.1 | L-2,4-diaminobutyrate decarboxylase of Bacteria UniRef RepID=B0BU02_ACTPJ. (510 aa) |
| | AHG85045.1 | Diaminobutyrate--2-oxoglutarate aminotransferase PRK06931; Diaminobutyrate--2-oxoglutarate aminotransferase of Bacteria UniRef RepID=DAT_HAEIN; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa) |
| | AHG85062.1 | Shikimate kinase PRK13946; Carbohydrate kinase, thermoresistant glucokinase family of Gammaproteobacteria UniRef RepID=A6WTN5_SHEB8. (171 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | gshB | Glutathione biosynthesis bifunctional protein gshAB; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily. (745 aa) |
| | F543_230 | Methylmalonate-semialdehyde dehydrogenase of Proteobacteria UniRef RepID=Q0K5K0_CUPNH. (504 aa) |
| | rbsK | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (307 aa) |
| | lldD | L-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (381 aa) |
| | putP | Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (502 aa) |
| | putA | 1-pyrroline-5-carboxylate dehydrogenase /proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1198 aa) |
| | glnA | Glutamine synthetase PRK09469; Glutamine synthetase of cellular organisms UniRef RepID=GLNA_SYNY3. (523 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | F543_3150 | L-asparaginase II PRK11096; L-asparaginase of Bacteria UniRef RepID=C6AJK5_AGGAN; Belongs to the asparaginase 1 family. (349 aa) |
| | carB | Carbamoyl phosphate synthase large subunit PRK05294; Carbamoyl-phosphate synthase large chain of cellular organisms UniRef RepID=CARB_HAEDU; Belongs to the CarB family. (1067 aa) |
| | carA | Carbamoyl phosphate synthase small subunit PRK12564; Carbamoyl-phosphate synthase small chain of root UniRef RepID=CARA_POLSQ; Belongs to the CarA family. (379 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (371 aa) |
| | F543_4170 | Transporter; Nucleoside permease COG1972; Uncharacterized transporter HI_0519 of Bacteria UniRef RepID=Y519_HAEIN; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (425 aa) |
| | F543_4180 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (258 aa) |
| | mtnN | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | ilvA | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (536 aa) |
| | luxS | S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (169 aa) |
| | katG | Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (722 aa) |
| | F543_4600 | Threonine synthase PRK09225; Threonine synthase of Bacteria UniRef RepID=THRC_BUCBP. (427 aa) |
| | serB | SerB protein; Phosphoserine phosphatase PRK11133; SerB protein of Pasteurellaceae UniRef RepID=Q65RP5_MANSM. (288 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa) |
| | grcA | Autonomous glycyl radical cofactor; Acts as a radical domain for damaged PFL and possibly other radical proteins. (127 aa) |
| | F543_4900 | Anthranilate synthase component II PRK06895; Anthranilate synthase component II of Pasteurellaceae UniRef RepID=B0BQ88_ACTPJ. (187 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (161 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | pgi | Glucose-6-phosphate isomerase PRK00179; Glucose-6-phosphate isomerase of root UniRef RepID=G6PI_HUMAN; Belongs to the GPI family. (546 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | F543_5480 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase of Pasteurellaceae UniRef RepID=B0BQ85_ACTPJ. (200 aa) |
| | F543_5490 | pabA-like protein; Para-aminobenzoate synthase component I PRK07093; Uncharacterized pabA-like protein HI_1170 of Proteobacteria UniRef RepID=Y1170_HAEIN. (322 aa) |
| | F543_6230 | Ribulose-phosphate 3-epimerase PRK08883; Ribulose-phosphate 3-epimerase of cellular organisms UniRef RepID=C3LRT6_VIBCM; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa) |
| | F543_6860 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1237 aa) |
| | F543_6950 | Glycerate dehydrogenase PRK06932; 2-hydroxyacid dehydrogenase HI_1556 of cellular organisms UniRef RepID=Y1556_HAEIN; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa) |
| | pepB | Peptidase B; Probably plays an important role in intracellular peptide degradation. (429 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa) |
| | pepA | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (491 aa) |
| | oadG | Oxaloacetate decarboxylase gamma chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (87 aa) |
| | oadA | Oxaloacetate decarboxylase PRK14040; Oxaloacetate decarboxylase alpha chain of cellular organisms UniRef RepID=DCOA_KLEPN. (601 aa) |
| | F543_7400 | Oxaloacetate decarboxylase beta chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (434 aa) |
| | F543_7830 | Branched-chain amino acid aminotransferase PRK13357; Branched-chain-amino-acid aminotransferase of cellular organisms UniRef RepID=ILVE_HAEIN. (340 aa) |
| | pyk | Pyruvate kinase PRK05826; Pyruvate kinase of root UniRef RepID=KPYK_HAEIN; Belongs to the pyruvate kinase family. (466 aa) |
| | F543_8060 | Homoserine kinase PRK01212; Homoserine kinase of Pasteurellaceae UniRef RepID=A4P0B7_HAEIF. (99 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (213 aa) |
| | F543_8080 | Bifunctional aspartokinase I/homoserine dehydrogenase I PRK09436; Bifunctional aspartokinase/homoserine dehydrogenase of Bacteria UniRef RepID=AKH_HAEIN; In the C-terminal section; belongs to the homoserine dehydrogenase family. (832 aa) |
| | tkt | Transketolase 2; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | trpE | Anthranilate synthase component I PRK13564; Anthranilate synthase component I of Gammaproteobacteria UniRef RepID=Q47YC4_COLP3. (454 aa) |
| | F543_8260 | Anthranilate synthase component I PRK13564; Anthranilate synthase component I of Haemophilus influenzae HK1212 UniRef RepID=D1NHI9_HAEIF. (50 aa) |
| | F543_8270 | Anthranilate synthase component II PRK05670; Anthranilate synthase component II of Gammaproteobacteria UniRef RepID=TRPG_VIBPA. (196 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (441 aa) |
| | aspA | Aspartate ammonia-lyase PRK12273; Aspartate ammonia-lyase of Bacteria UniRef RepID=ASPA_HAEIN. (474 aa) |
| | argG | Argininosuccinate synthase PRK05370; Argininosuccinate synthase of root UniRef RepID=Q46QJ6_CUPPJ; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (443 aa) |
| | F543_8920 | T-protein; Bifunctional chorismate mutase/prephenate dehydrogenase PRK11199; T-protein of Bacteria UniRef RepID=TYRA_HAEIN. (374 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (410 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (493 aa) |
| | F543_9440 | Acyl-CoA dehydrogenases COG1960; Acyl-CoA dehydrogenase of Bacteria UniRef RepID=B8F3P3_HAEPS. (354 aa) |
| | F543_9460 | Cystathionine beta-lyase PRK08114; Cystathionine beta-lyase of Proteobacteria UniRef RepID=METC_HAEIN. (235 aa) |
| | F543_9470 | Cystathionine beta-lyase PRK08114; Cystathionine beta-lyase of Proteobacteria UniRef RepID=METC_HAEIN. (152 aa) |
| | F543_9950 | Glyceraldehyde-3-phosphate dehydrogenase A PRK15425; Glyceraldehyde-3-phosphate dehydrogenase of root UniRef RepID=G3P_CRYNB; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (339 aa) |
