STRINGSTRING
ANP39389.1 ANP39389.1 ANP39390.1 ANP39390.1 ANP39444.1 ANP39444.1 ANP39457.1 ANP39457.1 edd edd zwf zwf pgi pgi gapA gapA ANP39563.1 ANP39563.1 ANP39587.1 ANP39587.1 ANP39592.1 ANP39592.1 ilvC ilvC leuA leuA glpX glpX prs prs ANP39866.1 ANP39866.1 ANP39957.1 ANP39957.1 rpiA rpiA ANP40007.1 ANP40007.1 ANP40249.1 ANP40249.1 ANP40300.1 ANP40300.1 fumC fumC pgl pgl ANP40625.1 ANP40625.1 gltA gltA ANP40668.1 ANP40668.1 gapA-2 gapA-2 ANP40684.1 ANP40684.1 pgk pgk pdhA pdhA ANP40702.1 ANP40702.1 ANP40703.1 ANP40703.1 ANP40752.1 ANP40752.1 ANP40772.1 ANP40772.1 ANP40821.1 ANP40821.1 eno eno ANP40905.1 ANP40905.1 ANP40906.1 ANP40906.1 tpiA tpiA glcB glcB ANP41117.1 ANP41117.1 ANP41230.1 ANP41230.1 ANP41234.1 ANP41234.1 ANP41235.1 ANP41235.1 tal tal ANP41383.1 ANP41383.1 pckA pckA ilvD ilvD leuC leuC leuD leuD ANP41500.1 ANP41500.1 ANP41767.1 ANP41767.1 ANP41784.1 ANP41784.1 gpmI gpmI ANP41809.1 ANP41809.1 ANP41810.1 ANP41810.1 ANP41811.1 ANP41811.1 ANP41812.1 ANP41812.1 ANP41813.1 ANP41813.1 ANP42014.1 ANP42014.1 rbsK rbsK ilvE ilvE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANP39389.1Hypothetical protein. (245 aa)
ANP39390.1Dihydrolipoamide dehydrogenase. (471 aa)
ANP39444.1Glucokinase; Belongs to the bacterial glucokinase family. (320 aa)
ANP39457.1Keto-deoxy-phosphogluconate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate. (215 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (603 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (483 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (536 aa)
gapAErythrose-4-phosphate dehydrogenase; Required for glycolysis; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
ANP39563.1Lactate dehydrogenase. (468 aa)
ANP39587.1Ribose-5-phosphate isomerase. (149 aa)
ANP39592.1Pyruvate, phosphate dikinase. (854 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (527 aa)
glpXType II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese. (327 aa)
prsPhosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (340 aa)
ANP39866.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1146 aa)
ANP39957.1Class I fructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis. (300 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (262 aa)
ANP40007.1Thiamine pyrophosphate-binding protein; Belongs to the TPP enzyme family. (570 aa)
ANP40249.1Malate dehydrogenase. (759 aa)
ANP40300.1Acetolactate synthase; Belongs to the TPP enzyme family. (537 aa)
fumCClass II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (223 aa)
ANP40625.1Citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (542 aa)
gltACitrate (Si)-synthase; Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Belongs to the citrate synthase family. (431 aa)
ANP40668.1Transketolase; Catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; Belongs to the transketolase family. (673 aa)
gapA-2Erythrose-4-phosphate dehydrogenase; Required for glycolysis; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
ANP40684.1E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component. (464 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Belongs to the phosphoglycerate kinase family. (396 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (337 aa)
ANP40702.1Pyruvate dehydrogenase complex E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (459 aa)
ANP40703.1Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (441 aa)
ANP40752.1Aconitate hydratase. (929 aa)
ANP40772.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (915 aa)
ANP40821.1Mannose-6-phosphate isomerase. (488 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
ANP40905.1Acetolactate synthase 3 large subunit. (583 aa)
ANP40906.1Acetolactate synthase small subunit. (186 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (246 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (709 aa)
ANP41117.1Phosphoglucomutase. (498 aa)
ANP41230.1ArsR family transcriptional regulator. (265 aa)
ANP41234.1MBL fold metallo-hydrolase. (356 aa)
ANP41235.1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (183 aa)
talFructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
ANP41383.1Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (362 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (532 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Belongs to the IlvD/Edd family. (614 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
ANP41500.1Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa)
ANP41767.1Transketolase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (794 aa)
ANP41784.12-dehydro-3-deoxygluconokinase. (308 aa)
gpmIPhosphoglycerate mutase (2,3-diphosphoglycerate-independent); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (506 aa)
ANP41809.1Dihydrolipoyl dehydrogenase. (452 aa)
ANP41810.1Branched-chain alpha-keto acid dehydrogenase subunit E2. (422 aa)
ANP41811.12-oxoisovalerate dehydrogenase. (337 aa)
ANP41812.12-oxoisovalerate dehydrogenase. (413 aa)
ANP41813.1Amino acid dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (356 aa)
ANP42014.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate. (751 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (290 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (288 aa)
Your Current Organism:
Epibacterium mobile
NCBI taxonomy Id: 1265309
Other names: E. mobile F1926, Epibacterium mobile F1926, Ruegeria mobilis F1926
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.