Your Input: | |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; COG0505; Belongs to the CarA family. (395 aa) |
| | ALL02080.1 | AMP phosphorylase; COG0213. (502 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (142 aa) |
| | thiI | Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (388 aa) |
| | ALL01973.1 | Acetolactate synthase large subunit; COG0028. (582 aa) |
| | nadK | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (275 aa) |
| | ALL01864.1 | Molybdenum cofactor biosynthesis bifunctional protein; COG0521. (174 aa) |
| | ALL01851.1 | Inositol-1-phosphate synthase; COG1260. (390 aa) |
| | pyrH | Uridine monophosphate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (224 aa) |
| | ALL01789.1 | Molybdopterin synthase subunit MoaD; COG1977. (95 aa) |
| | ALL01785.1 | Uracil phosphoribosyltransferase; COG0035. (220 aa) |
| | ALL01759.1 | Pyruvate kinase; COG0469; Belongs to the pyruvate kinase family. (466 aa) |
| | ALL01757.1 | 2-oxoglutarate oxidoreductase, beta subunit; COG1013. (320 aa) |
| | ALL01756.1 | 2-oxoglutarate oxidoreductase, alpha subunit; COG0674. (630 aa) |
| | ALL01744.1 | Hypothetical protein; COG0537. (172 aa) |
| | ALL01736.1 | Deoxyribose-phosphate aldolase; COG0274. (251 aa) |
| | ALL01725.1 | Hypothetical protein; COG1634. (260 aa) |
| | pgk | Phosphoglycerate kinase; COG0126; Belongs to the phosphoglycerate kinase family. (422 aa) |
| | gap | NAD(P)-dependent glyceraldehyde 3-phosphate dehydrogenase; COG0057. (343 aa) |
| | nnrE | Hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (526 aa) |
| | nadE | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (280 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (446 aa) |
| | ALL01684.1 | Molybdenum cofactor biosynthesis protein; COG0315. (163 aa) |
| | ALL01678.1 | Putative nucleotide kinase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (176 aa) |
| | ALL01662.1 | HD superfamily hydrolase; COG1896. (204 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (317 aa) |
| | folE | GTP cyclohydrolase I; COG0302. (189 aa) |
| | ALL01636.1 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; COG0717. (163 aa) |
| | thyX | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (326 aa) |
| | ALL01564.1 | Hypothetical protein. (338 aa) |
| | ALL01557.1 | Formate dehydrogenase chain D; COG1526. (277 aa) |
| | ALL01553.1 | Molybdopterin-guanine dinucleotide biosynthesis protein A; COG0746. (261 aa) |
| | rbcL | Ribulose-1,5-bisphosphate carboxylase, Type III; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (445 aa) |
| | ALL01546.1 | Histidine triad (HIT) protein; COG0537. (138 aa) |
| | ALL01499.1 | ADP-ribose pyrophosphatase; COG1051. (176 aa) |
| | ALL01490.1 | Pyruvate:ferredoxin oxidoreductase, delta subunit; COG1144. (117 aa) |
| | ALL01489.1 | Pyruvate:ferredoxin oxidoreductase, gamma subunit; COG1014. (213 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, PurS subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (84 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (225 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase, synthetase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (725 aa) |
| | purF | Glutamine amidotransferase class-II; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (451 aa) |
| | ALL01474.1 | Amidophosphoribosyltransferase. (407 aa) |
| | ALL01473.1 | Phosphoribosylamine/glycine ligase; COG0151. (492 aa) |
| | purT | Phosphoribosylaminoimidazole carboxylase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (411 aa) |
| | ALL01470.1 | Phosphoribosylformylglycinamidine cyclo-ligase; COG0150. (339 aa) |
| | ALL01446.1 | Phosphoribosyltransferase; COG0503. (235 aa) |
| | ALL01440.1 | Hypothetical protein; COG1408. (270 aa) |
| | ALL01436.1 | Molybdopterin converting factor, large subunit; COG0314. (224 aa) |
| | ALL01434.1 | Molybdopterin-guanine dinucleotide biosynthesis protein; COG1763. (158 aa) |
| | ALL01431.1 | Purine phosphoribosyl transferase; COG0503. (242 aa) |
| | ALL01380.1 | V-type ATP synthase subunit F; COG1436. (113 aa) |
| | ALL01379.1 | V-type ATP synthase subunit E; COG1390. (195 aa) |
| | atpA-2 | V-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (593 aa) |
| | atpB-2 | V-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (464 aa) |
| | ALL01376.1 | V-type ATP synthase subunit D; COG1394. (205 aa) |
| | ALL01362.1 | Phosphatidylserine synthase; COG1183; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (231 aa) |
| | ALL01355.1 | Inositol-1-monophosphatase; COG0483. (291 aa) |
| | ALL01331.1 | HD superfamily phosphohydrolase; COG1078. (510 aa) |
| | atpD | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (221 aa) |
| | atpB | V-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (473 aa) |
| | atpA | V-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (618 aa) |
| | atpE | V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (210 aa) |
| | ALL01320.1 | V-type ATP synthase subunit F; COG1436. (102 aa) |
| | ALL01318.1 | Archaeal/vacuolar-type H+-ATPase subunit C; COG1527. (337 aa) |
| | ALL01316.1 | Hypothetical protein; COG2403. (445 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (212 aa) |
| | ALL01232.1 | Nicotinate phosphoribosyltransferase; COG1488. (393 aa) |
| | ALL01224.1 | Ribokinase; COG0524. (309 aa) |
| | ALL01179.1 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal type; COG3635. (428 aa) |
| | ALL01175.1 | Molybdenum cofactor biosynthesis protein; COG2896. (334 aa) |
| | ALL01162.1 | Nicotinamide-nucleotide adenylyltransferase, NadM family; COG1056. (197 aa) |
| | ALL01161.1 | Hypothetical protein; COG3199. (378 aa) |
| | ALL01144.1 | Hypothetical protein; COG0644. (347 aa) |
| | ALL01122.1 | Competence damage-inducible protein A; COG1058. (256 aa) |
| | ALL01117.1 | Putative dehydrogenase; COG0644. (451 aa) |
| | ALL01092.1 | Hypothetical protein. (227 aa) |
| | adkA | Adenylate kinase, archaeal type; COG2019; Belongs to the archaeal adenylate kinase family. (205 aa) |
| | cmk | Cytidylate kinase; COG1102. (198 aa) |
| | ALL01036.1 | Sulfor transporting protein; COG1977. (91 aa) |
| | ALL01033.1 | Ribose 5-phosphate isomerase A; COG0120. (249 aa) |
| | surE | Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (284 aa) |
| | ALL00993.1 | Transketolase, C-terminal region; COG3958. (326 aa) |
| | ALL00992.1 | Transketolase, N-terminal region; COG3959. (319 aa) |
| | ALL00962.1 | Beta-lactamase domain-containing protein; COG1237. (232 aa) |
| | ALL00943.1 | CDP-alcohol phosphatidyltransferase; COG0558; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (194 aa) |
| | ALL00873.1 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; COG0452. (428 aa) |
| | ALL00870.1 | Pantothenate kinase; COG1829. (284 aa) |
| | ALL00869.1 | Acyl-CoA hydrolase; COG1607. (295 aa) |
| | ALL00868.1 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (313 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (292 aa) |
| | ALL00864.1 | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (287 aa) |
| | nadX | L-Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (259 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (139 aa) |
| | pyrD | Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (302 aa) |
| | ALL00845.1 | Adenylate cyclase; COG1437. (189 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (338 aa) |
| | ALL00839.1 | Adenylosuccinate lyase; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (467 aa) |
| | ALL00804.1 | Putative molybdenum transport system protein; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (290 aa) |
| | ALL00799.1 | IMP biosynthesis protein PurP domain containing protein; COG1759. (376 aa) |
| | ALL00797.1 | Phosphatidylglycerophosphate synthase; COG0558; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (221 aa) |
| | ALL00796.1 | Sugar nucleotidyltransferase; COG1213. (249 aa) |
| | ALL00789.1 | Thymidylate kinase; COG0125. (201 aa) |
| | ALL00735.1 | Molybdopterin converting factor, small subunit; COG1977. (93 aa) |
| | ALL00731.1 | Molybdopterin biosynthesis protein; COG0303. (431 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (538 aa) |
| | ALL00711.1 | Orotidine 5'-phosphate decarboxylase; COG0284. (227 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (204 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic subunit; COG0540. (323 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (164 aa) |
| | ALL00707.1 | Dihydroorotate dehydrogenase electron transfer subunit; COG0543. (262 aa) |
| | ALL00706.1 | Putative dihydroorotase; COG0044. (414 aa) |
| | ALL00683.1 | Uridine phosphorylase; COG2820. (267 aa) |
| | ALL00678.1 | Hypothetical protein; COG0644. (381 aa) |
| | ALL00673.1 | Phosphoribosyltransferase; COG2236. (227 aa) |
| | ALL00613.1 | Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (295 aa) |
| | ALL00606.1 | Putative dehydrogenase; COG0644. (355 aa) |
| | ALL00597.1 | Hypothetical protein; COG1694. (109 aa) |
| | ALL00596.1 | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (247 aa) |
| | carS | Hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (168 aa) |
| | ALL00530.1 | Nicotinamide-nucleotide adenylyltransferase; COG1056. (172 aa) |
| | egsA | NAD(P)-dependent glycerol-1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (349 aa) |
| | ALL00474.1 | acyl-CoA dehydrogenase; COG1960. (402 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (355 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (200 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; COG0458; Belongs to the CarB family. (1073 aa) |
| | ALL00416.1 | Acetyl-coenzyme A synthetase; COG0365. (668 aa) |
| | ALL00401.1 | Pantothenate synthetase; COG1701. (267 aa) |
| | ALL00398.1 | Hydroxymethylpyrimidine synthase; COG0422. (458 aa) |
| | thi4-2 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (284 aa) |
| | ALL00339.1 | IMP biosynthesis protein PurP domain containing protein; COG1759. (351 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (312 aa) |
| | ALL00322.1 | Putative quinolinate synthetase; COG0379. (311 aa) |
| | ALL00320.1 | Pyruvate:ferredoxin oxidoreductase, gamma subunit; COG1014. (192 aa) |
| | ALL00319.1 | Pyruvate:ferredoxin oxidoreductase, delta subunit; COG1144. (113 aa) |
| | ALL00292.1 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; COG1257; Belongs to the HMG-CoA reductase family. (422 aa) |
| | thi4 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (257 aa) |
| | tmk | Thymidylate kinase; COG0125. (222 aa) |
| | ALL00195.1 | Putative inosine-5'-monophosphate dehydrogenase; COG0516. (468 aa) |
| | guaA | Putative GMP synthase, amidotransferase subunit; Catalyzes the synthesis of GMP from XMP. (497 aa) |
| | ALL00176.1 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa) |
| | ALL00171.1 | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (189 aa) |
| | ALL00154.1 | Inosine/xanthosine triphosphatase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (197 aa) |
| | ALL00152.1 | Hypothetical protein; COG1893. (303 aa) |
| | ALL00107.1 | Putative nucleotide kinase; COG1936. (195 aa) |
| | ALL00104.1 | Phosphoribosyltransferase; COG2236. (203 aa) |
