107 items (Trichechus manatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC101349963	Inositol polyphosphate 5-phosphatase OCRL-1. (744 aa)
	LOC101359897	Sorting nexin-19 isoform X1. (1045 aa)
	LOC101360762	endophilin-A2 isoform X1. (402 aa)
	LOC101360231	Sorting nexin; Involved in several stages of intracellular trafficking. (411 aa)
	LOC101352192	Signal transducing adapter molecule 2 isoform X1. (550 aa)
	LOC101353592	Sorting nexin-8. (438 aa)
	LOC101355714	Lysosome-associated membrane glycoprotein 3. (426 aa)
	LOC101343359	E3 ubiquitin-protein ligase MARCH1 isoform X1. (360 aa)
	LOC101352380	Metalloreductase STEAP4 isoform X1. (508 aa)
	LOC101350576	Lethal(2) giant larvae protein homolog 1 isoform X1. (1017 aa)
	LOC101343624	Clavesin-2. (327 aa)
	LOC101355286	WD repeat-containing protein 91 isoform X1. (741 aa)
	LOC101358323	Sorting nexin-12 isoform X1. (173 aa)
	LOC101341195	Tumor susceptibility gene 101 protein isoform X1. (407 aa)
	LOC101346144	Two pore calcium channel protein 1. (819 aa)
	LOC101359894	1-phosphatidylinositol 3-phosphate 5-kinase isoform X1. (2120 aa)
	LOC101348955	dnaJ homolog subfamily C member 13 isoform X1. (2243 aa)
	LOC101348945	ATP-binding cassette sub-family A member 7. (2216 aa)
	LOC101355537	WASH complex subunit 1. (473 aa)
	LOC101353416	Sialidase-3 isoform X1. (419 aa)
	LOC101354131	Syntaxin-7; Belongs to the syntaxin family. (263 aa)
	LOC101346348	Mucolipin-3 isoform X1. (571 aa)
	LOC101351719	Protein wntless homolog isoform X1. (541 aa)
	LOC101341371	Type I inositol 3,4-bisphosphate 4-phosphatase. (972 aa)
	LOC101350682	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (803 aa)
	LOC101349928	Protein TMEPAI isoform X1. (238 aa)
	LOC101356086	Phosphatidylinositol 4-kinase type 2-alpha isoform X1. (479 aa)
	LOC101352687	Vacuolar protein sorting-associated protein 33B isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
	LOC101346710	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	LOC101348319	Sorting nexin-21. (361 aa)
	LOC101357687	Vesicle transport through interaction with t-SNAREs homolog 1B isoform X1. (232 aa)
	LOC101341296	endophilin-A3 isoform X1. (347 aa)
	LOC101349770	Neuronal vesicle trafficking-associated protein 2. (171 aa)
	LOC101351830	Glutamate receptor 1 isoform X2. (906 aa)
	LOC101358561	Zinc finger FYVE domain-containing protein. (1423 aa)
	LOC101354061	Sorting nexin-3. (162 aa)
	LOC101348582	Clavesin-1. (354 aa)
	LOC101343076	E3 ubiquitin-protein ligase DTX3L isoform X1. (745 aa)
	LOC101359705	Sorting nexin-4 isoform X1. (450 aa)
	LOC101354666	ADP-ribosylation factor-binding protein GGA2. (616 aa)
	LOC101358388	Amino acid transporter. (524 aa)
	LOC101357116	ADP-ribosylation factor-binding protein GGA1. (635 aa)
	LOC101341062	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (820 aa)
	LOC101349439	Sphingosine kinase 1. (471 aa)
	LOC101352616	Zinc finger FYVE domain-containing protein 16 isoform X1. (1547 aa)
	LOC101361001	Phosphatidylinositol 4-kinase type 2-beta isoform X1. (491 aa)
	LOC101340711	WD repeat-containing protein 81 isoform X1. (1938 aa)
	LOC101349539	ATP-binding cassette sub-family B member 6, mitochondrial isoform X1. (845 aa)
	LOC101344715	GRIP1-associated protein 1 isoform X1. (841 aa)
	LOC101360406	Syntaxin-12 isoform X1; Belongs to the syntaxin family. (274 aa)
	LOC101349450	Ephrin type-A receptor 8. (1193 aa)
	LOC101345114	CKLF-like MARVEL transmembrane domain-containing protein 6. (183 aa)
	LOC101352017	Protein RCC2. (525 aa)
	LOC101357885	Transmembrane glycoprotein NMB. (556 aa)
	LOC101360497	UBX domain-containing protein 6. (389 aa)
	LOC101359980	Phospholipid phosphatase 2. (287 aa)
	LOC101350574	Signal transducing adapter molecule 1 isoform X1. (540 aa)
	LOC101354943	Phospholipase A2. (863 aa)
	LOC101348110	Protein MON2 homolog isoform X1. (1720 aa)
	LOC101356135	LOW QUALITY PROTEIN: membrane magnesium transporter 1. (167 aa)
	LOC101361631	Lysosome-associated membrane glycoprotein 5. (217 aa)
	LOC101347938	GDT1 family protein. (323 aa)
	LOC101354358	Neuronal vesicle trafficking-associated protein 1 isoform X2. (185 aa)
	LOC101357402	VPS10 domain-containing receptor SorCS2. (1286 aa)
	LOC101356822	Receptor protein-tyrosine kinase. (1156 aa)
	LOC101347779	Sn1-specific diacylglycerol lipase alpha. (1040 aa)
	LOC101357492	Sorting nexin-2. (519 aa)
	LOC101348887	Lateral signaling target protein 2 homolog isoform X1. (837 aa)
	LOC101353176	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (860 aa)
	LOC101356825	PDZ and LIM domain protein 4 isoform X1. (332 aa)
	LOC101360706	Battenin. (438 aa)
	LOC101354787	Ras-related protein Rab-21 isoform X1. (222 aa)
	LOC101360791	Sorting nexin-16 isoform X1. (344 aa)
	LOC101353347	Activity-regulated cytoskeleton-associated protein. (397 aa)
	LOC101345755	CAP-Gly domain-containing linker protein 3. (547 aa)
	LOC101351384	Sortilin-related receptor isoform X1. (2213 aa)
	LOC101346801	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1491 aa)
	LOC101361415	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1. (394 aa)
	LOC101354072	Transmembrane protein 163. (257 aa)
	LOC101352321	LOW QUALITY PROTEIN: DCC-interacting protein 13-alpha. (625 aa)
	LOC101342178	Tyrosine-protein kinase receptor. (838 aa)
	LOC101354955	Annexin. (133 aa)
	LOC101353044	ADP-ribosylation factor-binding protein GGA3. (681 aa)
	LOC101346593	LOW QUALITY PROTEIN: sorting nexin-2-like. (519 aa)
	LOC101351975	LOW QUALITY PROTEIN: two pore calcium channel protein 1-like. (766 aa)
	LOC101345753	E3 ubiquitin-protein ligase MARCH8 isoform X2. (566 aa)
	LOC101341796	Sorting nexin-27 isoform X1. (565 aa)
	LOC101347137	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (469 aa)
	LOC101341049	Sorting nexin-20. (317 aa)
	LOC101360569	DCC-interacting protein 13-beta. (597 aa)
	LOC101345684	Low-density lipoprotein receptor class A domain-containing protein 4. (497 aa)
	LOC101341555	Type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1. (749 aa)
	LOC101358219	Sorting nexin-1 isoform X1. (547 aa)
	LOC101349795	Ras-related protein Rab-14. (215 aa)
	LOC101355173	Major histocompatibility complex class I-related gene protein isoform X1; Belongs to the MHC class I family. (351 aa)
	LOC101356368	Lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform X1. (194 aa)
	LOC101360486	Oxysterol-binding protein; Belongs to the OSBP family. (852 aa)
	LOC101362017	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1150 aa)
	LOC101360851	Sorting nexin-7. (310 aa)
	LOC101351147	Synapse differentiation-inducing gene protein 1. (289 aa)
	LOC101344995	Vesicle-associated membrane protein 8. (101 aa)
	LOC101351531	Chloride channel protein. (834 aa)
	LOC101356767	Chloride channel protein. (866 aa)
	LOC101346265	WASH complex subunit 2A. (1204 aa)
	LOC101341684	Myotubularin-related protein 2 isoform X1. (652 aa)
	LOC101342121	Bcl-2-related ovarian killer protein. (212 aa)
	LOC101342622	Transmembrane protein 184A. (260 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340711	LOC101341684	A0A2Y9DKA7	A0A2Y9RPH4	WD repeat-containing protein 81 isoform X1.	Myotubularin-related protein 2 isoform X1.	0.445
LOC101340711	LOC101349963	A0A2Y9DKA7	A0A2Y9R9C4	WD repeat-containing protein 81 isoform X1.	Inositol polyphosphate 5-phosphatase OCRL-1.	0.444
LOC101340711	LOC101352687	A0A2Y9DKA7	A0A2Y9D9Y5	WD repeat-containing protein 81 isoform X1.	Vacuolar protein sorting-associated protein 33B isoform X1; Belongs to the STXBP/unc-18/SEC1 family.	0.503
LOC101340711	LOC101355286	A0A2Y9DKA7	A0A2Y9REQ0	WD repeat-containing protein 81 isoform X1.	WD repeat-containing protein 91 isoform X1.	0.940
LOC101341062	LOC101341195	A0A2Y9DHG8	A0A2Y9RDR0	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Tumor susceptibility gene 101 protein isoform X1.	0.986
LOC101341062	LOC101344995	A0A2Y9DHG8	A0A2Y9S1Y0	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Vesicle-associated membrane protein 8.	0.503
LOC101341062	LOC101346593	A0A2Y9DHG8	A0A2Y9FZB0	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	LOW QUALITY PROTEIN: sorting nexin-2-like.	0.454
LOC101341062	LOC101350574	A0A2Y9DHG8	A0A2Y9DSZ5	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 1 isoform X1.	0.999
LOC101341062	LOC101352192	A0A2Y9DHG8	A0A2Y9R3E4	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 2 isoform X1.	0.999
LOC101341062	LOC101353044	A0A2Y9DHG8	A0A2Y9FZ93	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	ADP-ribosylation factor-binding protein GGA3.	0.421
LOC101341062	LOC101354061	A0A2Y9DHG8	A0A2Y9DDB5	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Sorting nexin-3.	0.566
LOC101341062	LOC101354131	A0A2Y9DHG8	A0A2Y9D6Z4	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Syntaxin-7; Belongs to the syntaxin family.	0.436
LOC101341062	LOC101356822	A0A2Y9DHG8	A0A2Y9DZ71	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Receptor protein-tyrosine kinase.	0.771
LOC101341062	LOC101357492	A0A2Y9DHG8	A0A2Y9DZF4	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Sorting nexin-2.	0.454
LOC101341062	LOC101358219	A0A2Y9DHG8	A0A2Y9QPU1	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Sorting nexin-1 isoform X1.	0.482
LOC101341062	LOC101358323	A0A2Y9DHG8	A0A2Y9REN1	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Sorting nexin-12 isoform X1.	0.566
LOC101341062	LOC101359894	A0A2Y9DHG8	A0A2Y9RB92	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	1-phosphatidylinositol 3-phosphate 5-kinase isoform X1.	0.586
LOC101341062	LOC101360406	A0A2Y9DHG8	A0A2Y9DM54	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Syntaxin-12 isoform X1; Belongs to the syntaxin family.	0.436
LOC101341195	LOC101341062	A0A2Y9RDR0	A0A2Y9DHG8	Tumor susceptibility gene 101 protein isoform X1.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.986
LOC101341195	LOC101346710	A0A2Y9RDR0	A0A2Y9DA81	Tumor susceptibility gene 101 protein isoform X1.	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.442