STRINGSTRING
LOC101350704 LOC101350704 LOC101354572 LOC101354572 LOC101350053 LOC101350053 LOC101340696 LOC101340696 LOC101342215 LOC101342215 LOC101345581 LOC101345581 LOC101353040 LOC101353040 LOC101361934 LOC101361934 LOC101346560 LOC101346560 LOC101356615 LOC101356615 LOC101344115 LOC101344115 LOC101341471 LOC101341471 LOC101348162 LOC101348162 LOC101345024 LOC101345024 LOC101343332 LOC101343332 LOC101359355 LOC101359355 LOC101360602 LOC101360602 LOC101352828 LOC101352828 LOC101355274 LOC101355274 LOC101347073 LOC101347073 LOC101352644 LOC101352644 LOC101360891 LOC101360891 LOC105756220 LOC105756220 LOC101356196 LOC101356196 LOC101360472 LOC101360472 LOC101347996 LOC101347996 LOC101360415 LOC101360415 LOC101355918 LOC101355918 LOC101360755 LOC101360755 LOC111820549 LOC111820549 LOC101354586 LOC101354586 LOC101343693 LOC101343693 LOC111821049 LOC111821049 LOC101359367 LOC101359367 LOC101342008 LOC101342008 LOC101344806 LOC101344806 LOC101354525 LOC101354525 LOC101361877 LOC101361877 LOC101340991 LOC101340991 LOC101354434 LOC101354434 LOC101357815 LOC101357815 LOC101359380 LOC101359380 LOC101351252 LOC101351252 LOC101351774 LOC101351774 LOC101349059 LOC101349059 LOC101360795 LOC101360795 LOC101354461 LOC101354461 LOC101344166 LOC101344166 LOC101359669 LOC101359669 LOC101352409 LOC101352409 LOC101358352 LOC101358352 LOC101361045 LOC101361045 LOC101348723 LOC101348723 LOC101357846 LOC101357846 LOC101346985 LOC101346985 LOC101343044 LOC101343044 LOC101346094 LOC101346094 LOC101358075 LOC101358075 LOC101351477 LOC101351477 LOC101346626 LOC101346626 LOC101346105 LOC101346105 LOC101355651 LOC101355651 LOC101343081 LOC101343081 LOC101347823 LOC101347823 LOC101356692 LOC101356692 LOC101350273 LOC101350273 LOC101346033 LOC101346033 LOC101341010 LOC101341010 LOC101360514 LOC101360514 LOC101341510 LOC101341510 LOC101356822 LOC101356822 LOC101343024 LOC101343024 LOC101357146 LOC101357146 LOC101358862 LOC101358862 LOC101356744 LOC101356744 LOC101354947 LOC101354947 LOC101340313 LOC101340313 LOC101355788 LOC101355788 LOC101343517 LOC101343517 LOC101355359 LOC101355359 LOC101351153 LOC101351153 LOC101354514 LOC101354514 LOC101341078 LOC101341078 LOC101350648 LOC101350648 LOC101346489 LOC101346489 LOC101346158 LOC101346158 LOC101359484 LOC101359484 LOC101345820 LOC101345820 LOC101342040 LOC101342040 LOC101343375 LOC101343375 LOC101357607 LOC101357607 LOC101342543 LOC101342543 LOC101360673 LOC101360673 LOC101357563 LOC101357563 LOC101346138 LOC101346138 LOC101344961 LOC101344961 LOC101345712 LOC101345712 LOC101354258 LOC101354258 LOC101346740 LOC101346740 LOC101354334 LOC101354334 LOC101356463 LOC101356463 LOC101341996 LOC101341996 LOC101344464 LOC101344464 LOC101347669 LOC101347669 LOC101348255 LOC101348255 LOC101358222 LOC101358222 LOC101347997 LOC101347997 LOC101348422 LOC101348422 LOC101345878 LOC101345878 LOC101343943 LOC101343943 LOC101346082 LOC101346082 LOC101358434 LOC101358434 LOC101348624 LOC101348624 LOC101348961 LOC101348961 LOC101345331 LOC101345331 LOC101357644 LOC101357644 LOC101344411 LOC101344411 LOC101360432 LOC101360432 LOC101351324 LOC101351324 LOC101355178 LOC101355178 LOC101348356 LOC101348356 LOC101340536 LOC101340536 LOC105756396 LOC105756396 LOC101354748 LOC101354748 LOC101341063 LOC101341063 LOC101347848 LOC101347848 LOC101347347 LOC101347347 LOC101346973 LOC101346973 LOC101347585 LOC101347585 LOC101354918 LOC101354918 LOC101359268 LOC101359268 LOC101346088 LOC101346088 LOC101355639 LOC101355639 LOC101344556 LOC101344556 LOC101356495 LOC101356495 LOC101346849 LOC101346849 LOC101343991 LOC101343991 LOC101344178 LOC101344178 LOC101360806 LOC101360806 LOC101355323 LOC101355323 LOC101352759 LOC101352759 LOC101357520 LOC101357520 LOC101346183 LOC101346183 LOC101349669 LOC101349669 LOC101346196 LOC101346196 LOC101353982 LOC101353982 LOC101360209 LOC101360209 LOC101356098 LOC101356098
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101350704Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
LOC101354572Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
LOC101350053cyclin-K; Belongs to the cyclin family. (524 aa)
LOC101340696ALK and LTK ligand 2. (152 aa)
LOC101342215Angiopoietin-4. (534 aa)
LOC101345581Rapamycin-insensitive companion of mTOR isoform X1. (1733 aa)
LOC1013530403-phosphoinositide-dependent protein kinase 1. (636 aa)
LOC101361934Insulin-like growth factor I isoform X1. (189 aa)
LOC101346560G-protein coupled receptor family C group 5 member B. (387 aa)
LOC101356615Caspase recruitment domain-containing protein 10. (1027 aa)
LOC101344115Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC101341471G-protein coupled receptor family C group 5 member C. (438 aa)
LOC101348162Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)
LOC101345024Pseudokinase FAM20A. (541 aa)
LOC101343332Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC101359355Integrin beta; Belongs to the integrin beta chain family. (742 aa)
LOC101360602Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LOC101352828Appetite-regulating hormone. (117 aa)
LOC101355274Toll/interleukin-1 receptor domain-containing adapter protein. (221 aa)
LOC101347073LOW QUALITY PROTEIN: protein DBF4 homolog B. (803 aa)
LOC101352644Mitogen-activated protein kinase kinase kinase. (952 aa)
LOC101360891Girdin isoform X1. (2034 aa)
LOC10575622060S acidic ribosomal protein P1-like. (135 aa)
LOC101356196Amphiregulin. (254 aa)
LOC101360472Protein p13 MTCP-1. (107 aa)
LOC101347996Actin filament-associated protein 1-like 2 isoform X2. (791 aa)
LOC101360415Tyrosine-protein kinase receptor. (1056 aa)
LOC101355918Protransforming growth factor alpha isoform X1. (162 aa)
LOC101360755Receptor tyrosine-protein kinase erbB-4. (853 aa)
LOC111820549Receptor tyrosine-protein kinase erbB-4-like. (370 aa)
LOC101354586Calcium-binding protein 39-like. (334 aa)
LOC101343693Regulator of cell cycle RGCC isoform X1. (156 aa)
LOC111821049P2X purinoceptor 7-like isoform X1. (232 aa)
LOC101359367Prohibitin. (272 aa)
LOC101342008Cyclin-dependent kinase inhibitor 1 isoform X1. (189 aa)
LOC101344806Signal-transducing adaptor protein 1 isoform X1. (300 aa)
LOC101354525CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
LOC101361877Gremlin. (184 aa)
LOC101340991Abl interactor 1 isoform X10. (508 aa)
LOC101354434Receptor tyrosine-protein kinase erbB-3. (1340 aa)
LOC101357815Serine/threonine-protein kinase WNK1 isoform X6. (2638 aa)
LOC101359380Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC101351252Protein DBF4 homolog A isoform X1. (680 aa)
LOC101351774Tyrosine-protein kinase receptor. (894 aa)
LOC101349059Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (346 aa)
LOC101360795Retinoic acid-induced protein 3. (354 aa)
LOC101354461ALK and LTK ligand 1. (145 aa)
LOC101344166Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
LOC101359669cyclin-Y isoform X1; Belongs to the cyclin family. (341 aa)
LOC101352409MOB kinase activator 3B. (242 aa)
LOC101358352Prohibitin. (299 aa)
LOC101361045G-protein coupled receptor family C group 5 member D isoform X1. (344 aa)
LOC101348723cyclin-T1; Belongs to the cyclin family. (727 aa)
LOC101357846Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LOC101346985Axin-1 isoform X1. (878 aa)
LOC101343044DAZ-associated protein 2 isoform X2. (207 aa)
LOC101346094Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC101358075Platelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LOC101351477Integrin beta-1-binding protein 1. (200 aa)
LOC101346626Tyrosine-protein kinase receptor. (752 aa)
LOC101346105Targeting protein for Xklp2. (730 aa)
LOC101355651Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
LOC101343081LOW QUALITY PROTEIN: regulatory-associated protein of mTOR. (1718 aa)
LOC101347823MOB kinase activator 3C isoform X1. (274 aa)
LOC101356692Calcium-binding protein 39 isoform X2. (341 aa)
LOC101350273Interleukin-1 receptor-associated kinase 1. (826 aa)
LOC101346033Claspin. (1470 aa)
LOC101341010Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (139 aa)
LOC101360514Protein ECT2 isoform X5. (906 aa)
LOC101341510Protein PRRC1. (445 aa)
LOC101356822Receptor protein-tyrosine kinase. (1156 aa)
LOC101343024Diacylglycerol kinase. (911 aa)
LOC101357146Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
LOC101358862Pro-neuregulin-1, membrane-bound isoform isoform X1. (700 aa)
LOC101356744Epigen. (153 aa)
LOC101354947Protein-tyrosine kinase 2-beta isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
LOC101340313Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LOC101355788arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1192 aa)
LOC101343517Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (819 aa)
LOC101355359Hepatocyte nuclear factor 1-alpha isoform X1. (638 aa)
LOC101351153TOM1-like protein 1. (545 aa)
LOC101354514Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
LOC101341078Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC101350648MOB kinase activator 3A. (217 aa)
LOC101346489Tyrosine-protein kinase receptor. (1625 aa)
LOC101346158Proepiregulin. (98 aa)
LOC101359484alpha-2C adrenergic receptor. (152 aa)
LOC101345820Inner centromere protein. (922 aa)
LOC101342040DNA excision repair protein ERCC-6 isoform X1. (1495 aa)
LOC101343375Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC101357607Activity-dependent neuroprotector homeobox protein isoform X1. (1159 aa)
LOC101342543Transforming growth factor beta; Belongs to the TGF-beta family. (392 aa)
LOC101360673Urocortin. (125 aa)
LOC101357563cyclin-Y-like protein 1 isoform X1; Belongs to the cyclin family. (365 aa)
LOC101346138Alsin. (1658 aa)
LOC101344961STE20-related kinase adapter protein beta isoform X1. (418 aa)
LOC101345712Speedy protein A. (313 aa)
LOC101354258TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC101346740T-cell leukemia/lymphoma protein 1A. (117 aa)
LOC101354334Calcium/calmodulin-dependent protein kinase kinase 1. (505 aa)
LOC101356463Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
LOC101341996Cyclin-dependent kinase 5 activator 2. (96 aa)
LOC101344464Natural resistance-associated macrophage protein 1. (575 aa)
LOC101347669Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC101348255Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (212 aa)
LOC101358222Chitinase-3-like protein 1 isoform X1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
LOC101347997Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1642 aa)
LOC10134842260S acidic ribosomal protein P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
LOC101345878cyclin-T2 isoform X1; Belongs to the cyclin family. (733 aa)
LOC101343943alpha-2A adrenergic receptor. (464 aa)
LOC101346082Cyclin-dependent kinase 5 activator. (307 aa)
LOC101358434COP9 signalosome complex subunit 8 isoform X1. (214 aa)
LOC101348624Interleukin-18. (201 aa)
LOC101348961MOB kinase activator 1B. (216 aa)
LOC101345331TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LOC101357644Death ligand signal enhancer. (569 aa)
LOC101344411Oxysterol-binding protein; Belongs to the OSBP family. (903 aa)
LOC101360432Probetacellulin. (181 aa)
LOC101351324Disabled homolog 2-interacting protein. (1173 aa)
LOC101355178Non-specific serine/threonine protein kinase. (524 aa)
LOC101348356Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
LOC101340536Nck-associated protein 1-like isoform X1. (1138 aa)
LOC105756396Insulin receptor-like. (210 aa)
LOC101354748STE20-related kinase adapter protein alpha isoform X1. (407 aa)
LOC101341063Poly [ADP-ribose] polymerase. (322 aa)
LOC101347848LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase kinase 2. (548 aa)
LOC101347347P2X purinoceptor 7. (178 aa)
LOC101346973Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
LOC101347585T-lymphocyte activation antigen CD86 isoform X1. (311 aa)
LOC101354918Tyrosine-protein kinase. (1106 aa)
LOC101359268Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
LOC101346088Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
LOC101355639Fibrillin-1. (2870 aa)
LOC101344556Proheparin-binding EGF-like growth factor. (208 aa)
LOC101356495TNF receptor-associated factor. (470 aa)
LOC101346849Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101343991Proto-oncogene Mas; Belongs to the G-protein coupled receptor 1 family. (325 aa)
LOC101344178Ewing's tumor-associated antigen 1 isoform X1. (904 aa)
LOC101360806Growth arrest-specific protein 6. (675 aa)
LOC101355323LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3. (551 aa)
LOC101352759Death domain-associated protein 6. (739 aa)
LOC101357520E3 ubiquitin-protein ligase ZFP91. (575 aa)
LOC101346183alpha-2B adrenergic receptor. (445 aa)
LOC101349669MOB kinase activator 1A isoform X1. (216 aa)
LOC101346196CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
LOC101353982Protein sprouty homolog 2. (315 aa)
LOC101360209Protein aurora borealis isoform X1. (554 aa)
LOC101356098Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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