(41 nodes) Tumor necrosis factor-mediated signaling pathway network (Trichechus manatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC101354918	Tyrosine-protein kinase. (1106 aa)
	LOC101350627	TNF receptor-associated factor. (415 aa)
	LOC101357884	Tumor necrosis factor receptor superfamily member 1B isoform X1. (458 aa)
	LOC101362016	Tumor necrosis factor receptor superfamily member 17. (202 aa)
	LOC101351852	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
	LOC101359471	Tumor necrosis factor receptor superfamily member 13C. (350 aa)
	LOC101347503	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	LOC101351256	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	LOC101341290	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
	LOC101342230	Tumor necrosis factor ligand superfamily member 18. (181 aa)
	LOC101342356	Tumor necrosis factor receptor superfamily member 18 isoform X1. (227 aa)
	LOC101345331	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	LOC101358050	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (608 aa)
	LOC111819201	LOW QUALITY PROTEIN: interferon-inducible protein AIM2-like. (136 aa)
	TNF	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (234 aa)
	LOC101341627	COMM domain-containing protein 7 isoform X1. (243 aa)
	LOC101357919	Apoptosis-associated speck-like protein containing a CARD. (205 aa)
	LOC101354211	Suppression of tumorigenicity 18 protein isoform X1. (1014 aa)
	LOC101355445	Tumor necrosis factor receptor superfamily member 11A. (867 aa)
	LOC101361676	Adapter protein CIKS. (563 aa)
	LOC101354911	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (509 aa)
	LOC101346618	Integrin-linked protein kinase. (452 aa)
	LOC101347873	Tumor necrosis factor receptor superfamily member 19. (424 aa)
	LOC101355632	Tumor necrosis factor receptor superfamily member 4. (276 aa)
	LOC101354947	Protein-tyrosine kinase 2-beta isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	LOC101340999	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (288 aa)
	LOC101347404	Cell death-inducing p53-target protein 1 isoform X1. (208 aa)
	LOC101356055	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
	LOC101353500	E3 SUMO-protein ligase PIAS3. (627 aa)
	LOC101351163	LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27. (300 aa)
	LOC101350310	CD70 antigen; Belongs to the tumor necrosis factor family. (193 aa)
	LOC101342165	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
	LOC101355353	NF-kappa-B inhibitor alpha. (314 aa)
	LOC101350803	Thioredoxin domain-containing protein 17. (123 aa)
	LOC101357916	Signal transducer and activator of transcription. (752 aa)
	LOC101361706	Transcription factor p65. (538 aa)
	LOC105756783	Pyrin domain-containing protein 1. (89 aa)
	LOC101341867	Tumor necrosis factor receptor superfamily member 1A. (453 aa)
	LOC101355946	Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (493 aa)
	LOC101345873	Caspase recruitment domain-containing protein 14. (996 aa)
	LOC101355511	Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (434 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340999	LOC101341867	A0A2Y9DX57	A0A2Y9RZR5	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 1A.	0.519
LOC101340999	LOC101342165	A0A2Y9DX57	A0A2Y9DL90	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family.	0.733
LOC101340999	LOC101347503	A0A2Y9DX57	A0A2Y9R7H0	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.707
LOC101340999	LOC101350627	A0A2Y9DX57	A0A2Y9QUT9	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor.	0.537
LOC101340999	LOC101354911	A0A2Y9DX57	A0A2Y9EC52	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.537
LOC101340999	LOC101355445	A0A2Y9DX57	A0A2Y9FXT3	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 11A.	0.570
LOC101340999	LOC101357884	A0A2Y9DX57	A0A2Y9QX63	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 1B isoform X1.	0.573
LOC101340999	LOC101358050	A0A2Y9DX57	A0A2Y9QRF4	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.603
LOC101340999	LOC101359471	A0A2Y9DX57	A0A2Y9R6Z2	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 13C.	0.997
LOC101340999	LOC101362016	A0A2Y9DX57	A0A2Y9QXJ6	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 17.	0.996
LOC101340999	TNF	A0A2Y9DX57	A0A2Y9QPJ3	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family.	0.614
LOC101341290	LOC101341867	A0A2Y9D9M8	A0A2Y9RZR5	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	Tumor necrosis factor receptor superfamily member 1A.	0.968
LOC101341290	LOC101345331	A0A2Y9D9M8	A0A2Y9RIB6	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.989
LOC101341290	LOC101347503	A0A2Y9D9M8	A0A2Y9R7H0	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.828
LOC101341290	LOC101350627	A0A2Y9D9M8	A0A2Y9QUT9	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	TNF receptor-associated factor.	0.694
LOC101341290	LOC101351256	A0A2Y9D9M8	A0A2Y9RFY1	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.998
LOC101341290	LOC101351852	A0A2Y9D9M8	A0A2Y9R5B9	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.506
LOC101341290	LOC101354911	A0A2Y9D9M8	A0A2Y9EC52	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.968
LOC101341290	LOC101355353	A0A2Y9D9M8	A0A2Y9DL46	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	NF-kappa-B inhibitor alpha.	0.998
LOC101341290	LOC101357916	A0A2Y9D9M8	A0A2Y9RKH7	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	Signal transducer and activator of transcription.	0.500