(15 nodes) Stress fiber assembly network (Trichechus manatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101357400	Phosphatase and actin regulator. (648 aa)
	LOC101358845	Serum response factor isoform X2. (585 aa)
	LOC101345527	Integrin beta; Belongs to the integrin beta chain family. (892 aa)
	LOC101353421	Serine/threonine-protein kinase B-raf. (743 aa)
	LOC101345153	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1. (329 aa)
	LOC101347560	Sorbin and SH3 domain-containing protein 1. (1293 aa)
	LOC101361550	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2. (316 aa)
	LOC101354947	Protein-tyrosine kinase 2-beta isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	LOC101361450	Zyxin. (570 aa)
	LOC101340836	LIM domain kinase 1 isoform X1. (647 aa)
	LOC101346062	Protein FAM171A1. (769 aa)
	LOC101357721	FH2 domain-containing protein 1. (1144 aa)
	LOC101359624	Cullin-3 isoform X1; Belongs to the cullin family. (768 aa)
	LOC101347586	Protein FAM171A2. (689 aa)
	LOC101343353	Elastin. (757 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101345153	LOC101359624	A0A2Y9E5C3	A0A2Y9DKY0	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1.	Cullin-3 isoform X1; Belongs to the cullin family.	0.734
LOC101345153	LOC101361550	A0A2Y9E5C3	A0A2Y9E1L3	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	0.665
LOC101345527	LOC101347560	A0A2Y9FZ25	A0A2Y9D8R8	Integrin beta; Belongs to the integrin beta chain family.	Sorbin and SH3 domain-containing protein 1.	0.632
LOC101345527	LOC101354947	A0A2Y9FZ25	A0A2Y9DX75	Integrin beta; Belongs to the integrin beta chain family.	Protein-tyrosine kinase 2-beta isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.594
LOC101347560	LOC101345527	A0A2Y9D8R8	A0A2Y9FZ25	Sorbin and SH3 domain-containing protein 1.	Integrin beta; Belongs to the integrin beta chain family.	0.632
LOC101354947	LOC101345527	A0A2Y9DX75	A0A2Y9FZ25	Protein-tyrosine kinase 2-beta isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Integrin beta; Belongs to the integrin beta chain family.	0.594
LOC101359624	LOC101345153	A0A2Y9DKY0	A0A2Y9E5C3	Cullin-3 isoform X1; Belongs to the cullin family.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1.	0.734
LOC101359624	LOC101361550	A0A2Y9DKY0	A0A2Y9E1L3	Cullin-3 isoform X1; Belongs to the cullin family.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	0.676
LOC101361550	LOC101345153	A0A2Y9E1L3	A0A2Y9E5C3	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1.	0.665
LOC101361550	LOC101359624	A0A2Y9E1L3	A0A2Y9DKY0	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	Cullin-3 isoform X1; Belongs to the cullin family.	0.676