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LOC111819422 LOC111819422 LOC101361070 LOC101361070 LOC111819284 LOC111819284 LOC101355069 LOC101355069 LOC101353949 LOC101353949 LOC105756982 LOC105756982 LOC101343646 LOC101343646 LOC101353922 LOC101353922 LOC101352375 LOC101352375 LOC101355190 LOC101355190 LOC101360146 LOC101360146 LOC101358207 LOC101358207 LOC105756124 LOC105756124 LOC101349091 LOC101349091 LOC101349865 LOC101349865 LOC101348404 LOC101348404 LOC101357180 LOC101357180 LOC101357936 LOC101357936 LOC101358454 LOC101358454 LOC101345256 LOC101345256 LOC101357429 LOC101357429 LOC101357682 LOC101357682 LOC101359509 LOC101359509 LOC101354128 LOC101354128 LOC101341184 LOC101341184 LOC101342368 LOC101342368 LOC101355226 LOC101355226 LOC101361644 LOC101361644 LOC101344907 LOC101344907 LOC101342124 LOC101342124 LOC101359844 LOC101359844 LOC101342884 LOC101342884 LOC101358787 LOC101358787 LOC101342628 LOC101342628 LOC101357246 LOC101357246 LOC101347788 LOC101347788 LOC101353190 LOC101353190 LOC101355994 LOC101355994 LOC101359579 LOC101359579 LOC101344812 LOC101344812 LOC101353686 LOC101353686 LOC101348798 LOC101348798 LOC101343981 LOC101343981 LOC101344492 LOC101344492 LOC101353937 LOC101353937 LOC101351618 LOC101351618 LOC101348789 LOC101348789 LOC101347615 LOC101347615 LOC101359413 LOC101359413 LOC101348804 LOC101348804 LOC111822869 LOC111822869 LOC101340334 LOC101340334 LOC101350416 LOC101350416 LOC101354467 LOC101354467 LOC101352752 LOC101352752 LOC101358086 LOC101358086 LOC101344247 LOC101344247 LOC101344738 LOC101344738 LOC111822625 LOC111822625 LOC101353177 LOC101353177 LOC101360794 LOC101360794 LOC101355724 LOC101355724 LOC101349047 LOC101349047 LOC101341608 LOC101341608 LOC101360529 LOC101360529 LOC101340744 LOC101340744 LOC101360545 LOC101360545 LOC101348374 LOC101348374 LOC101341098 LOC101341098 LOC101353680 LOC101353680 LOC101352653 LOC101352653 LOC101351878 LOC101351878 LOC101357482 LOC101357482 LOC101343723 LOC101343723 LOC101349824 LOC101349824 LOC101354448 LOC101354448 LOC101354703 LOC101354703 LOC101348288 LOC101348288 LOC101348617 LOC101348617 LOC111821397 LOC111821397 LOC101357981 LOC101357981 LOC101348095 LOC101348095 LOC101351950 LOC101351950 LOC101340734 LOC101340734 LOC101343337 LOC101343337 LOC101347849 LOC101347849 LOC101344229 LOC101344229 LOC101350299 LOC101350299 LOC101351066 LOC101351066 LOC101350810 LOC101350810 LOC101354585 LOC101354585 LOC101346585 LOC101346585 LOC101347919 LOC101347919 LOC101352983 LOC101352983 LOC101341331 LOC101341331 LOC111820053 LOC111820053 LOC101360536 LOC101360536 LOC101351056 LOC101351056 LOC101348982 LOC101348982 LOC101350587 LOC101350587 LOC101346422 LOC101346422 LOC101359652 LOC101359652 LOC101353427 LOC101353427 LOC101351355 LOC101351355 LOC101352138 LOC101352138 LOC101349310 LOC101349310 LOC101361893 LOC101361893 LOC111819674 LOC111819674 LOC101354166 LOC101354166 LOC101345666 LOC101345666 LOC111820408 LOC111820408 LOC101349183 LOC101349183 LOC101349825 LOC101349825 LOC101352393 LOC101352393 LOC101359542 LOC101359542 LOC101341643 LOC101341643 LOC101345280 LOC101345280 LOC101357385 LOC101357385 LOC101352879 LOC101352879 LOC101345123 LOC101345123 LOC101344298 LOC101344298 LOC101347853 LOC101347853 LOC101355693 LOC101355693 LOC101341736 LOC101341736 LOC101354080 LOC101354080 LOC101360506 LOC101360506 LOC101355281 LOC101355281 LOC101343007 LOC101343007 LOC101350322 LOC101350322 LOC101347859 LOC101347859 LOC101340322 LOC101340322 LOC101347626 LOC101347626 LOC101345924 LOC101345924 LOC101349328 LOC101349328 LOC101344510 LOC101344510 LOC101358362 LOC101358362 LOC101345172 LOC101345172 LOC101346706 LOC101346706 LOC101351461 LOC101351461 LOC101362007 LOC101362007 LOC101354567 LOC101354567 LOC101357444 LOC101357444 LOC101361502 LOC101361502 LOC101359955 LOC101359955 LOC101360744 LOC101360744 LOC101357033 LOC101357033 LOC101359010 LOC101359010 LOC101353479 LOC101353479 LOC101342486 LOC101342486 LOC101347998 LOC101347998 LOC111820089 LOC111820089 LOC101344508 LOC101344508 LOC101348834 LOC101348834 LOC101360481 LOC101360481 LOC101355763 LOC101355763 LOC101357594 LOC101357594 LOC101354652 LOC101354652 LOC101344834 LOC101344834 LOC101344107 LOC101344107 LOC101358200 LOC101358200
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111819422E1A-binding protein p400-like. (535 aa)
LOC101361070Histone H2A; Belongs to the histone H2A family. (112 aa)
LOC111819284Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC101355069Meiotic recombination protein REC8 homolog. (567 aa)
LOC101353949Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105756982Histone H2A; Belongs to the histone H2A family. (116 aa)
LOC101343646LOW QUALITY PROTEIN: uncharacterized protein LOC101343646; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (331 aa)
LOC101353922Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101352375SWI/SNF complex subunit SMARCC2 isoform X3. (1245 aa)
LOC101355190MPN domain-containing protein. (564 aa)
LOC101360146Histone H3.3-like. (136 aa)
LOC101358207Histone H2A; Belongs to the histone H2A family. (117 aa)
LOC105756124LOW QUALITY PROTEIN: protamine-2. (110 aa)
LOC101349091Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101349865Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101348404TERF1-interacting nuclear factor 2 isoform X1. (452 aa)
LOC101357180Histone H2A; Belongs to the histone H2A family. (151 aa)
LOC101357936Histone H2A; Belongs to the histone H2A family. (78 aa)
LOC101358454Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101345256Vacuolar protein sorting-associated protein 72 homolog isoform X2. (374 aa)
LOC101357429Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101357682Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101359509Structural maintenance of chromosomes protein. (1233 aa)
LOC101354128Zinc finger protein neuro-d4 isoform X1. (424 aa)
LOC101341184Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC101342368Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101355226Protein SSXT isoform X1. (418 aa)
LOC101361644Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101344907Actin-like protein 6B isoform X1; Belongs to the actin family. (426 aa)
LOC101342124Uncharacterized protein LOC101342124; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (629 aa)
LOC101359844Histone H1.5. (225 aa)
LOC101342884Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1375 aa)
LOC101358787DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
LOC101342628Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101357246Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
LOC101347788SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
LOC101353190B-cell CLL/lymphoma 7 protein family member C. (217 aa)
LOC101355994Kinetochore protein Nuf2. (477 aa)
LOC101359579Inhibitor of growth protein. (418 aa)
LOC101344812Histone H2A; Belongs to the histone H2A family. (143 aa)
LOC101353686Histone H2A; Belongs to the histone H2A family. (118 aa)
LOC101348798Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC101343981Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101344492Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101353937Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101351618Histone H1.4-like. (213 aa)
LOC101348789Uncharacterized protein LOC101348789; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (328 aa)
LOC101347615AT-rich interactive domain-containing protein 2 isoform X1. (1835 aa)
LOC101359413annotation not available (559 aa)
LOC101348804Telomeric repeat-binding factor 2-interacting protein 1. (399 aa)
LOC111822869Histone H2B type 1-A-like; Belongs to the histone H2B family. (125 aa)
LOC101340334Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC101350416YEATS domain-containing protein 4 isoform X1. (259 aa)
LOC101354467Enhancer of polycomb homolog. (874 aa)
LOC101352752Kinetochore protein NDC80 homolog. (612 aa)
LOC101358086E1A-binding protein p400. (2457 aa)
LOC101344247Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101344738Histone H3; Belongs to the histone H3 family. (136 aa)
LOC111822625Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (113 aa)
LOC101353177Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101360794Cohesin subunit SA-3. (1224 aa)
LOC101355724Histone H2B type 1-like; Belongs to the histone H2B family. (131 aa)
LOC101349047Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101341608Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101360529Protection of telomeres protein 1. (457 aa)
LOC101340744Zinc finger protein ubi-d4 isoform X2. (425 aa)
LOC101360545CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (374 aa)
LOC101348374Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2063 aa)
LOC101341098Histone H3.1-like. (160 aa)
LOC101353680Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101352653Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101351878Histone H1.2. (213 aa)
LOC101357482Sphingosine kinase 2. (651 aa)
LOC101343723Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101349824Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101354448Lysine-specific histone demethylase 1B isoform X1. (716 aa)
LOC101354703Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101348288Histone H1.1. (214 aa)
LOC101348617Condensin-2 complex subunit H2 isoform X1. (639 aa)
LOC111821397Histone H3.3-like. (129 aa)
LOC101357981LOW QUALITY PROTEIN: bromodomain-containing protein 8. (1242 aa)
LOC101348095MBT domain-containing protein 1 isoform X1. (654 aa)
LOC101351950Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3854 aa)
LOC101340734Cohesin subunit SA-1 isoform X1. (1325 aa)
LOC101343337Heterochromatin protein 1-binding protein 3 isoform X1. (563 aa)
LOC101347849Structural maintenance of chromosomes protein. (1223 aa)
LOC101344229Bromodomain-containing protein 9. (864 aa)
LOC101350299LOW QUALITY PROTEIN: B-cell lymphoma/leukemia 11B. (824 aa)
LOC101351066Transcription activator BRG1 isoform X1. (1650 aa)
LOC101350810Kinetochore protein Spc24. (210 aa)
LOC101354585CST complex subunit CTC1. (1218 aa)
LOC101346585Cohesin subunit SA-2 isoform X1. (1268 aa)
LOC101347919Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (837 aa)
LOC101352983Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1528 aa)
LOC101341331Shugoshin 2. (1344 aa)
LOC111820053Probable global transcription activator SNF2L2. (282 aa)
LOC101360536PHD finger protein 10 isoform X1. (483 aa)
LOC101351056SMC5-SMC6 complex localization factor protein 1 isoform X1. (1041 aa)
LOC101348982Protein polybromo-1 isoform X1. (1413 aa)
LOC101350587Histone H3.1-like; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (225 aa)
LOC101346422Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
LOC101359652Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
LOC101353427Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101351355Histone H1.4. (219 aa)
LOC101352138Histone H1t. (212 aa)
LOC101349310Histone H1.3. (220 aa)
LOC101361893Histone H2B type 1-A; Belongs to the histone H2B family. (126 aa)
LOC111819674Protein polybromo-1-like. (145 aa)
LOC101354166Probable global transcription activator SNF2L2 isoform X1. (1276 aa)
LOC101345666SWI/SNF complex subunit SMARCC1 isoform X1. (1033 aa)
LOC111820408LOW QUALITY PROTEIN: CST complex subunit TEN1. (138 aa)
LOC101349183Putative oxidoreductase GLYR1 isoform X1. (596 aa)
LOC101349825Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (538 aa)
LOC101352393Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101359542Pleckstrin homology domain-containing family A member 1 isoform X1. (406 aa)
LOC101341643Histone H2B subacrosomal variant-like; Belongs to the histone H2B family. (122 aa)
LOC101345280Condensin complex subunit 3. (1015 aa)
LOC101357385Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC101352879Kinetochore protein Spc25. (226 aa)
LOC101345123Histone H3; Belongs to the histone H3 family. (132 aa)
LOC101344298AT-rich interactive domain-containing protein 1A isoform X1. (2276 aa)
LOC101347853Structural maintenance of chromosomes protein. (1234 aa)
LOC101355693Histone H3-like centromeric protein A isoform X1. (135 aa)
LOC101341736Spermatid nuclear transition protein 1. (55 aa)
LOC101354080Histone H2A; Belongs to the histone H2A family. (118 aa)
LOC101360506B-cell CLL/lymphoma 7 protein family member B isoform X1. (202 aa)
LOC101355281RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
LOC101343007SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1. (411 aa)
LOC101350322Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2006 aa)
LOC101347859Actin-like protein 6A isoform X1; Belongs to the actin family. (429 aa)
LOC101340322Histone H2B type 1-A-like; Belongs to the histone H2B family. (127 aa)
LOC101347626RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
LOC101345924Histone H1x. (219 aa)
LOC101349328Histone H1oo. (346 aa)
LOC101344510Condensin complex subunit 2. (603 aa)
LOC101358362B-cell lymphoma/leukemia 11A isoform X1. (835 aa)
LOC101345172MRG/MORF4L-binding protein. (203 aa)
LOC101346706Calcium-responsive transactivator isoform X1. (399 aa)
LOC101351461Double-strand-break repair protein rad21-like protein 1. (555 aa)
LOC101362007Chromatin modification-related protein MEAF6 isoform X1. (201 aa)
LOC101354567Structural maintenance of chromosomes protein. (1191 aa)
LOC101357444DNA methyltransferase 1-associated protein 1. (468 aa)
LOC101361502Double-strand-break repair protein rad21 homolog. (631 aa)
LOC101359955SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (483 aa)
LOC101360744Protamine-3. (90 aa)
LOC101357033Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101359010Histone H1.0. (194 aa)
LOC101353479SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2. (531 aa)
LOC101342486Structural maintenance of chromosomes protein. (1217 aa)
LOC101347998Enhancer of polycomb homolog. (818 aa)
LOC111820089AT-rich interactive domain-containing protein 1B-like isoform X1. (492 aa)
LOC101344508AT-rich interactive domain-containing protein 1B isoform X1. (1287 aa)
LOC101348834Histone H2A; Belongs to the histone H2A family. (166 aa)
LOC101360481Nuclear transition protein 2. (178 aa)
LOC101355763Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
LOC101357594E3 ubiquitin-protein ligase SHPRH isoform X1. (1685 aa)
LOC101354652LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog. (464 aa)
LOC101344834Zinc finger protein DPF3. (377 aa)
LOC101344107Condensin-2 complex subunit G2 isoform X1. (1140 aa)
LOC101358200Histone H3-like. (136 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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