(34 nodes) T cell selection network (Trichechus manatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101347632	Tyrosine-protein kinase. (617 aa)
	LOC101358845	Serum response factor isoform X2. (585 aa)
	LOC101350299	LOW QUALITY PROTEIN: B-cell lymphoma/leukemia 11B. (824 aa)
	LOC101359660	T-cell surface glycoprotein CD3 epsilon chain isoform X1. (218 aa)
	LOC111822470	piggyBac transposable element-derived protein 4. (604 aa)
	LOC101351806	Tyrosine-protein kinase. (685 aa)
	LOC101358693	HLA class II histocompatibility antigen gamma chain isoform X3. (267 aa)
	LOC101356003	Interleukin-6 receptor subunit alpha isoform X1. (470 aa)
	LOC101343648	T-cell surface glycoprotein CD4 isoform X1. (488 aa)
	LOC101343808	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	LOC101345568	Autoimmune regulator. (663 aa)
	LOC101355035	Transcriptional activator GLI3. (1586 aa)
	LOC101343014	Signal transducer and activator of transcription. (847 aa)
	LOC101347007	Apoptosis regulator Bcl-2 isoform X1. (229 aa)
	LOC101354514	Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
	LOC101346659	T-box transcription factor TBX21. (536 aa)
	LOC101351590	Interleukin-6. (237 aa)
	LOC101357528	Basic leucine zipper transcriptional factor ATF-like. (122 aa)
	LOC101342651	Signal transducer and activator of transcription. (783 aa)
	LOC101353380	LOW QUALITY PROTEIN: butyrophilin-like protein 1. (520 aa)
	LOC101353421	Serine/threonine-protein kinase B-raf. (743 aa)
	LOC101349423	Protein THEMIS. (647 aa)
	LOC101340854	Caspase recruitment domain-containing protein 11. (1155 aa)
	LOC101341683	Interleukin; Belongs to the IL-15/IL-21 family. (210 aa)
	LOC101353008	T-cell surface glycoprotein CD3 delta chain isoform X1. (172 aa)
	LOC101359688	T-lymphocyte surface antigen Ly-9 isoform X1. (663 aa)
	LOC101359947	T-lymphocyte surface antigen Ly-9-like isoform X1. (498 aa)
	LOC101351212	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	LOC101349277	Thymocyte selection-associated high mobility group box protein TOX. (515 aa)
	LOC101342758	C-C chemokine receptor type 7 isoform X2; Belongs to the G-protein coupled receptor 1 family. (423 aa)
	LOC101361011	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1077 aa)
	LOC101344210	Receptor-type tyrosine-protein phosphatase C isoform X1. (1305 aa)
	LOC101354015	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (447 aa)
	LOC101357212	Kinase; Belongs to the inositol phosphokinase (IPK) family. (921 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340854	LOC101347632	A0A2Y9E3Y7	A0A2Y9R636	Caspase recruitment domain-containing protein 11.	Tyrosine-protein kinase.	0.505
LOC101340854	LOC101351806	A0A2Y9E3Y7	A0A2Y9RSF2	Caspase recruitment domain-containing protein 11.	Tyrosine-protein kinase.	0.567
LOC101341683	LOC101342651	A0A2Y9E271	A0A2Y9QCU4	Interleukin; Belongs to the IL-15/IL-21 family.	Signal transducer and activator of transcription.	0.548
LOC101341683	LOC101343014	A0A2Y9E271	A0A2Y9DRZ6	Interleukin; Belongs to the IL-15/IL-21 family.	Signal transducer and activator of transcription.	0.402
LOC101341683	LOC101343648	A0A2Y9E271	A0A2Y9RYS9	Interleukin; Belongs to the IL-15/IL-21 family.	T-cell surface glycoprotein CD4 isoform X1.	0.724
LOC101341683	LOC101346659	A0A2Y9E271	A0A2Y9DP38	Interleukin; Belongs to the IL-15/IL-21 family.	T-box transcription factor TBX21.	0.550
LOC101341683	LOC101351590	A0A2Y9E271	A0A2Y9DMT4	Interleukin; Belongs to the IL-15/IL-21 family.	Interleukin-6.	0.633
LOC101341683	LOC101356003	A0A2Y9E271	A0A2Y9RTT9	Interleukin; Belongs to the IL-15/IL-21 family.	Interleukin-6 receptor subunit alpha isoform X1.	0.760
LOC101342651	LOC101341683	A0A2Y9QCU4	A0A2Y9E271	Signal transducer and activator of transcription.	Interleukin; Belongs to the IL-15/IL-21 family.	0.548
LOC101342651	LOC101343014	A0A2Y9QCU4	A0A2Y9DRZ6	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.898
LOC101342651	LOC101343648	A0A2Y9QCU4	A0A2Y9RYS9	Signal transducer and activator of transcription.	T-cell surface glycoprotein CD4 isoform X1.	0.740
LOC101342651	LOC101343808	A0A2Y9QCU4	A0A2Y9E154	Signal transducer and activator of transcription.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.618
LOC101342651	LOC101344210	A0A2Y9QCU4	A0A2Y9R396	Signal transducer and activator of transcription.	Receptor-type tyrosine-protein phosphatase C isoform X1.	0.441
LOC101342651	LOC101346659	A0A2Y9QCU4	A0A2Y9DP38	Signal transducer and activator of transcription.	T-box transcription factor TBX21.	0.416
LOC101342651	LOC101347007	A0A2Y9QCU4	A0A2Y9DRK5	Signal transducer and activator of transcription.	Apoptosis regulator Bcl-2 isoform X1.	0.709
LOC101342651	LOC101351590	A0A2Y9QCU4	A0A2Y9DMT4	Signal transducer and activator of transcription.	Interleukin-6.	0.831
LOC101342651	LOC101351806	A0A2Y9QCU4	A0A2Y9RSF2	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.763
LOC101342651	LOC101353421	A0A2Y9QCU4	A0A2Y9FYY4	Signal transducer and activator of transcription.	Serine/threonine-protein kinase B-raf.	0.540
LOC101342651	LOC101354015	A0A2Y9QCU4	A0A2Y9R3R7	Signal transducer and activator of transcription.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.515
LOC101342651	LOC101356003	A0A2Y9QCU4	A0A2Y9RTT9	Signal transducer and activator of transcription.	Interleukin-6 receptor subunit alpha isoform X1.	0.975