(24 nodes) Isotype switching network (Trichechus manatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101357092	Uncharacterized protein KIAA1841 homolog. (717 aa)
	LOC101348216	Single-stranded DNA cytosine deaminase. (244 aa)
	LOC101350608	Exosome complex component MTR3. (281 aa)
	LOC101340478	DNA ligase. (915 aa)
	LOC101353409	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (489 aa)
	LOC101346880	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
	LOC101358733	E3 ubiquitin-protein ligase RNF168-like. (257 aa)
	LOC101360358	LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF168-like. (350 aa)
	LOC101345932	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1358 aa)
	LOC101360292	Differentially expressed in FDCP 6 homolog isoform X1. (634 aa)
	LOC101343284	ATPase family AAA domain-containing protein 5. (1855 aa)
	LOC101350478	B-cell lymphoma 6 protein. (706 aa)
	LOC101354771	DNA excision repair protein ERCC-1. (299 aa)
	LOC101354525	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	LOC101343014	Signal transducer and activator of transcription. (847 aa)
	LOC101351862	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (318 aa)
	LOC101347000	DNA mismatch repair protein Mlh1. (758 aa)
	LOC101361863	Forkhead box protein P3 isoform X1. (429 aa)
	LOC101351145	Exonuclease 1. (836 aa)
	LOC101341985	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
	LOC101342475	Exosome complex component RRP40 isoform X1. (274 aa)
	LOC101357528	Basic leucine zipper transcriptional factor ATF-like. (122 aa)
	LOC101349075	Switch-associated protein 70 isoform X1. (585 aa)
	LOC101346702	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340478	LOC101343284	A0A2Y9RMI3	A0A2Y9E1K5	DNA ligase.	ATPase family AAA domain-containing protein 5.	0.620
LOC101340478	LOC101345932	A0A2Y9RMI3	A0A2Y9FXZ4	DNA ligase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.705
LOC101340478	LOC101346702	A0A2Y9RMI3	A0A2Y9D7R5	DNA ligase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.632
LOC101340478	LOC101346880	A0A2Y9RMI3	A0A2Y9QJ75	DNA ligase.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.801
LOC101340478	LOC101347000	A0A2Y9RMI3	A0A2Y9DMP5	DNA ligase.	DNA mismatch repair protein Mlh1.	0.568
LOC101340478	LOC101351145	A0A2Y9RMI3	A0A2Y9DJJ8	DNA ligase.	Exonuclease 1.	0.856
LOC101340478	LOC101351862	A0A2Y9RMI3	A0A2Y9DRS0	DNA ligase.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.574
LOC101340478	LOC101354771	A0A2Y9RMI3	A0A2Y9DUP6	DNA ligase.	DNA excision repair protein ERCC-1.	0.654
LOC101341985	LOC101346880	A0A2Y9DFK8	A0A2Y9QJ75	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.492
LOC101341985	LOC101353409	A0A2Y9DFK8	A0A2Y9R335	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.597
LOC101342475	LOC101350608	A0A2Y9DCX5	A0A2Y9RVK4	Exosome complex component RRP40 isoform X1.	Exosome complex component MTR3.	0.998
LOC101342475	LOC101351862	A0A2Y9DCX5	A0A2Y9DRS0	Exosome complex component RRP40 isoform X1.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.424
LOC101343014	LOC101350478	A0A2Y9DRZ6	A0A2Y9DXA5	Signal transducer and activator of transcription.	B-cell lymphoma 6 protein.	0.460
LOC101343014	LOC101361863	A0A2Y9DRZ6	A0A2Y9DLG9	Signal transducer and activator of transcription.	Forkhead box protein P3 isoform X1.	0.427
LOC101343284	LOC101340478	A0A2Y9E1K5	A0A2Y9RMI3	ATPase family AAA domain-containing protein 5.	DNA ligase.	0.620
LOC101343284	LOC101345932	A0A2Y9E1K5	A0A2Y9FXZ4	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.493
LOC101343284	LOC101346702	A0A2Y9E1K5	A0A2Y9D7R5	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.441
LOC101343284	LOC101346880	A0A2Y9E1K5	A0A2Y9QJ75	ATPase family AAA domain-containing protein 5.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.460
LOC101343284	LOC101351145	A0A2Y9E1K5	A0A2Y9DJJ8	ATPase family AAA domain-containing protein 5.	Exonuclease 1.	0.911
LOC101345932	LOC101340478	A0A2Y9FXZ4	A0A2Y9RMI3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA ligase.	0.705