STRINGSTRING
LOC101362054 LOC101362054 LOC101345557 LOC101345557 LOC101355281 LOC101355281 LOC101360596 LOC101360596 LOC101344644 LOC101344644 LOC101351254 LOC101351254 LOC101357481 LOC101357481 LOC101351781 LOC101351781 LOC101359830 LOC101359830 LOC101347859 LOC101347859 LOC101349720 LOC101349720 LOC101356822 LOC101356822 LOC101359652 LOC101359652 LOC101347615 LOC101347615 LOC101359579 LOC101359579 LOC101353190 LOC101353190 LOC101357666 LOC101357666 LOC101361716 LOC101361716 LOC101342951 LOC101342951 LOC101343205 LOC101343205 LOC101344907 LOC101344907 LOC101350165 LOC101350165 LOC101345256 LOC101345256 LOC101342461 LOC101342461 LOC101359258 LOC101359258 LOC101360733 LOC101360733 LOC101346266 LOC101346266 LOC101361871 LOC101361871 LOC105756529 LOC105756529 LOC101360358 LOC101360358 LOC105756303 LOC105756303 LOC101346879 LOC101346879 LOC101347882 LOC101347882 LOC101359785 LOC101359785 LOC101358733 LOC101358733 LOC101351797 LOC101351797 LOC111819422 LOC111819422 LOC101344763 LOC101344763 LOC101356605 LOC101356605 LOC101359794 LOC101359794 LOC111819440 LOC111819440 LOC101347998 LOC101347998 LOC101344836 LOC101344836 LOC101343684 LOC101343684 LOC101352003 LOC101352003 LOC101351056 LOC101351056 LOC101350294 LOC101350294 LOC101351756 LOC101351756 LOC101352161 LOC101352161 LOC101347071 LOC101347071 LOC101358932 LOC101358932 LOC101361865 LOC101361865 LOC101352104 LOC101352104 LOC101348260 LOC101348260 LOC101352494 LOC101352494 LOC101352923 LOC101352923 LOC101343560 LOC101343560 LOC101350416 LOC101350416 LOC101354467 LOC101354467 LOC101356080 LOC101356080 LOC101358086 LOC101358086 LOC101361643 LOC101361643 LOC101342040 LOC101342040 LOC101355561 LOC101355561 LOC101359499 LOC101359499 LOC101361556 LOC101361556 LOC101341253 LOC101341253 LOC101349145 LOC101349145 LOC101345394 LOC101345394 LOC101354350 LOC101354350 LOC101352807 LOC101352807 LOC101354349 LOC101354349 LOC101354024 LOC101354024 LOC101344396 LOC101344396 LOC101353819 LOC101353819 LOC101357981 LOC101357981 LOC101359977 LOC101359977 LOC101348095 LOC101348095 LOC101351950 LOC101351950 LOC101361607 LOC101361607 LOC111820453 LOC111820453 LOC101353409 LOC101353409 LOC101357961 LOC101357961 LOC101347626 LOC101347626 LOC101358101 LOC101358101 LOC101347470 LOC101347470 LOC101345172 LOC101345172 LOC101354304 LOC101354304 LOC101344601 LOC101344601 LOC101362007 LOC101362007 LOC101357444 LOC101357444 LOC101340277 LOC101340277 LOC101341985 LOC101341985 LOC101343076 LOC101343076 LOC101346733 LOC101346733 LOC101346218 LOC101346218 LOC101357711 LOC101357711 LOC101355609 LOC101355609 LOC101349879 LOC101349879 LOC101344382 LOC101344382 LOC101340638 LOC101340638 LOC101341332 LOC101341332 LOC101360240 LOC101360240 LOC101348443 LOC101348443 LOC101347092 LOC101347092 LOC101352029 LOC101352029
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101362054Histone-lysine N-methyltransferase KMT5B isoform X1. (883 aa)
LOC101345557Bifunctional polynucleotide phosphatase/kinase isoform X1. (521 aa)
LOC101355281RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
LOC10136059640S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
LOC101344644Oocyte-expressed protein homolog. (141 aa)
LOC101351254Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC101357481Histone-lysine N-methyltransferase KMT5C. (457 aa)
LOC101351781TCF3 fusion partner. (254 aa)
LOC101359830Uncharacterized protein C20orf196 homolog isoform X1. (221 aa)
LOC101347859Actin-like protein 6A isoform X1; Belongs to the actin family. (429 aa)
LOC101349720Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LOC101356822Receptor protein-tyrosine kinase. (1156 aa)
LOC101359652Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
LOC101347615AT-rich interactive domain-containing protein 2 isoform X1. (1835 aa)
LOC101359579Inhibitor of growth protein. (418 aa)
LOC101353190B-cell CLL/lymphoma 7 protein family member C. (217 aa)
LOC101357666RNA-binding protein FUS isoform X1. (522 aa)
LOC101361716MRN complex-interacting protein. (338 aa)
LOC101342951NAD-dependent protein deacetylase sirtuin-1 isoform X1. (742 aa)
LOC101343205INO80 complex subunit E isoform X1. (250 aa)
LOC101344907Actin-like protein 6B isoform X1; Belongs to the actin family. (426 aa)
LOC101350165LOW QUALITY PROTEIN: DNA repair protein XRCC1. (630 aa)
LOC101345256Vacuolar protein sorting-associated protein 72 homolog isoform X2. (374 aa)
LOC101342461Pogo transposable element with ZNF domain. (1413 aa)
LOC101359258BRCA1-A complex subunit Abraxas 1 isoform X1. (409 aa)
LOC101360733Lys-63-specific deubiquitinase BRCC36 isoform X1. (313 aa)
LOC101346266Histone-lysine N-methyltransferase SETMAR. (308 aa)
LOC101361871Nuclear factor related to kappa-B-binding protein. (1311 aa)
LOC105756529RAD51-associated protein 1. (186 aa)
LOC101360358LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF168-like. (350 aa)
LOC105756303Actin-related protein 2. (106 aa)
LOC101346879Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (503 aa)
LOC101347882Protein FAM178B. (1092 aa)
LOC101359785Helicase POLQ-like isoform X1. (1062 aa)
LOC101358733E3 ubiquitin-protein ligase RNF168-like. (257 aa)
LOC101351797Protein FAM35A isoform X1. (907 aa)
LOC111819422E1A-binding protein p400-like. (535 aa)
LOC101344763Protein spire homolog 1. (725 aa)
LOC101356605Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1851 aa)
LOC101359794ATP-dependent RNA helicase A isoform X1. (1281 aa)
LOC111819440Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (124 aa)
LOC101347998Enhancer of polycomb homolog. (818 aa)
LOC101344836BRCA1-A complex subunit RAP80 isoform X1. (750 aa)
LOC101343684DNA excision repair protein ERCC-8. (412 aa)
LOC101352003UNC93-like protein MFSD11. (449 aa)
LOC101351056SMC5-SMC6 complex localization factor protein 1 isoform X1. (1041 aa)
LOC101350294Telomere-associated protein RIF1 isoform X1. (2475 aa)
LOC101351756LOW QUALITY PROTEIN: DNA repair-scaffolding protein. (421 aa)
LOC101352161Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (585 aa)
LOC101347071Poly [ADP-ribose] polymerase. (675 aa)
LOC101358932Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (571 aa)
LOC101361865Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
LOC101352104Uncharacterized protein FLJ26957-like. (249 aa)
LOC101348260wiskott-Aldrich syndrome protein isoform X1. (534 aa)
LOC101352494Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1814 aa)
LOC101352923Fanconi anemia group B protein isoform X1. (868 aa)
LOC101343560SMC5-SMC6 complex localization factor protein 2 isoform X1. (1167 aa)
LOC101350416YEATS domain-containing protein 4 isoform X1. (259 aa)
LOC101354467Enhancer of polycomb homolog. (874 aa)
LOC101356080Microspherule protein 1 isoform X1. (513 aa)
LOC101358086E1A-binding protein p400. (2457 aa)
LOC101361643Transcription intermediary factor 1-beta. (1046 aa)
LOC101342040DNA excision repair protein ERCC-6 isoform X1. (1495 aa)
LOC101355561DNA endonuclease RBBP8 isoform X1. (899 aa)
LOC101359499Coiled-coil domain-containing protein 117 isoform X1. (222 aa)
LOC101361556Zinc finger CW-type PWWP domain protein 1. (486 aa)
LOC101341253Ubiquitin carboxyl-terminal hydrolase. (413 aa)
LOC101349145BRISC and BRCA1-A complex member 1. (329 aa)
LOC101345394Transmembrane protein 161A. (459 aa)
LOC101354350ATP-dependent DNA helicase DDX11. (969 aa)
LOC101352807Fructose-2,6-bisphosphatase TIGAR isoform X1. (270 aa)
LOC101354349Forkhead box protein M1 isoform X1. (762 aa)
LOC101354024Protein FAM168A isoform X1. (244 aa)
LOC101344396KHDC3-like protein. (171 aa)
LOC101353819INO80 complex subunit D. (1027 aa)
LOC101357981LOW QUALITY PROTEIN: bromodomain-containing protein 8. (1242 aa)
LOC101359977Protein spire homolog 2. (692 aa)
LOC101348095MBT domain-containing protein 1 isoform X1. (654 aa)
LOC101351950Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3854 aa)
LOC101361607WD repeat-containing protein 48. (672 aa)
LOC111820453DNA repair-scaffolding protein-like. (611 aa)
LOC101353409E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (489 aa)
LOC101357961methylated-DNA--protein-cysteine methyltransferase. (199 aa)
LOC101347626RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
LOC101358101Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
LOC101347470Poly [ADP-ribose] polymerase. (536 aa)
LOC101345172MRG/MORF4L-binding protein. (203 aa)
LOC101354304MMS19 nucleotide excision repair protein homolog isoform X1. (1030 aa)
LOC101344601CCAAT/enhancer-binding protein gamma. (150 aa)
LOC101362007Chromatin modification-related protein MEAF6 isoform X1. (201 aa)
LOC101357444DNA methyltransferase 1-associated protein 1. (468 aa)
LOC101340277Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
LOC101341985E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
LOC101343076E3 ubiquitin-protein ligase DTX3L isoform X1. (745 aa)
LOC101346733DNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4134 aa)
LOC101346218Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. (145 aa)
LOC101357711Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
LOC101355609Telomerase Cajal body protein 1. (540 aa)
LOC101349879Fumarate hydratase, mitochondrial. (508 aa)
LOC101344382BRISC and BRCA1-A complex member 2 isoform X1. (383 aa)
LOC101340638NAD-dependent protein deacetylase sirtuin-6 isoform X1. (359 aa)
LOC101341332E3 SUMO-protein ligase PIAS4. (516 aa)
LOC101360240Hepatoma-derived growth factor-related protein 2. (674 aa)
LOC101348443Protein timeless homolog. (1204 aa)
LOC101347092Histone deacetylase 10. (704 aa)
LOC101352029DNA helicase INO80. (1558 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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