(59 nodes) Positive regulation of exocytosis network (Trichechus manatus)

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Your Input:
	LOC101346695	Endothelial transcription factor GATA-2. (480 aa)
	LOC101345160	Hyaluronidase. (591 aa)
	LOC101361150	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
	LOC101357699	Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
	LOC101359705	Sorting nexin-4 isoform X1. (450 aa)
	LOC101345870	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2178 aa)
	LOC101345872	85/88 kDa calcium-independent phospholipase A2 isoform X1. (836 aa)
	LOC101341062	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (820 aa)
	LOC101351408	Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
	LOC101347505	Erythroid transcription factor. (413 aa)
	LOC101348599	Programmed cell death 6-interacting protein isoform X1. (879 aa)
	LOC101360847	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	LOC101350062	Ras-related protein Rab-3D. (219 aa)
	LOC101341660	Fibrinogen gamma chain isoform X1. (444 aa)
	LOC101360765	Ras-related protein Rab-27B. (218 aa)
	LOC101358673	Group 3 secretory phospholipase A2. (498 aa)
	LOC101350574	Signal transducing adapter molecule 1 isoform X1. (540 aa)
	LOC101359735	Synaptotagmin-4 isoform X1. (425 aa)
	LOC101340998	Exophilin-5 isoform X3. (2017 aa)
	LOC101346426	Zona pellucida sperm-binding protein 3. (431 aa)
	LOC101359052	Protein KIAA0100 homolog isoform X1. (2234 aa)
	LOC101355044	Syntaxin-4; Belongs to the syntaxin family. (298 aa)
	LOC101357247	Calcium-dependent secretion activator 2 isoform X2. (1301 aa)
	LOC101344507	Anion exchange protein. (1092 aa)
	LOC101340776	CD177 antigen-like. (253 aa)
	LOC101346801	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1491 aa)
	LOC101342093	Fibrinogen beta chain isoform X1. (489 aa)
	LOC101340676	Synaptotagmin-9. (470 aa)
	LOC101359350	Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family. (230 aa)
	LOC105757025	Ras-related protein Rab-15. (166 aa)
	LOC101350431	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (197 aa)
	LOC101343042	LOW QUALITY PROTEIN: calcium-dependent secretion activator 1. (1313 aa)
	LOC101354807	Synaptotagmin-10. (490 aa)
	LOC101357367	Secretory carrier-associated membrane protein. (262 aa)
	LOC101352005	Protein unc-13 homolog D. (1090 aa)
	LOC101346389	Syntaxin-binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
	LOC101345276	Ras-related protein Rab-27A. (221 aa)
	LOC101349784	Syntenin-1 isoform X1. (298 aa)
	LOC101361519	Tyrosine-protein kinase. (527 aa)
	LOC101344111	Voltage-dependent T-type calcium channel subunit alpha-1H. (2355 aa)
	LOC101353816	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1179 aa)
	LOC101359199	Synaptotagmin-like protein 4. (673 aa)
	LOC101347681	Vacuolar protein sorting-associated protein 4B isoform X1; Belongs to the AAA ATPase family. (452 aa)
	LOC101349026	CLIP-associating protein 2 isoform X1. (1501 aa)
	LOC101351856	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
	LOC101357895	CD160 antigen. (183 aa)
	LOC101348272	Voltage-dependent L-type calcium channel subunit beta-2. (595 aa)
	LOC101341195	Tumor susceptibility gene 101 protein isoform X1. (407 aa)
	LOC101344056	Lysosome-associated membrane glycoprotein 1 isoform X1. (416 aa)
	LOC101348888	Vacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family. (447 aa)
	LOC101341264	Interleukin-13. (135 aa)
	LOC101357482	Sphingosine kinase 2. (651 aa)
	LOC101348031	Synaptotagmin-7 isoform X1. (518 aa)
	LOC101355642	Charged multivesicular body protein 2a. (222 aa)
	LOC101351806	Tyrosine-protein kinase. (685 aa)
	LOC101341119	CLIP-associating protein 1 isoform X1. (1502 aa)
	LOC101350098	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (312 aa)
	LOC101341033	CD177 antigen. (434 aa)
	LOC101344995	Vesicle-associated membrane protein 8. (101 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340676	LOC101344995	A0A2Y9G151	A0A2Y9S1Y0	Synaptotagmin-9.	Vesicle-associated membrane protein 8.	0.501
LOC101340676	LOC101346801	A0A2Y9G151	A0A2Y9E9B0	Synaptotagmin-9.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.400
LOC101340676	LOC101359350	A0A2Y9G151	A0A2Y9G4B9	Synaptotagmin-9.	Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family.	0.405
LOC101340676	LOC101359735	A0A2Y9G151	A0A2Y9DTT3	Synaptotagmin-9.	Synaptotagmin-4 isoform X1.	0.433
LOC101341062	LOC101341195	A0A2Y9DHG8	A0A2Y9RDR0	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Tumor susceptibility gene 101 protein isoform X1.	0.986
LOC101341062	LOC101344056	A0A2Y9DHG8	A0A2Y9RFN9	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Lysosome-associated membrane glycoprotein 1 isoform X1.	0.547
LOC101341062	LOC101344995	A0A2Y9DHG8	A0A2Y9S1Y0	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Vesicle-associated membrane protein 8.	0.503
LOC101341062	LOC101347681	A0A2Y9DHG8	A0A2Y9R2N6	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Vacuolar protein sorting-associated protein 4B isoform X1; Belongs to the AAA ATPase family.	0.591
LOC101341062	LOC101348599	A0A2Y9DHG8	A0A2Y9DMI8	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Programmed cell death 6-interacting protein isoform X1.	0.745
LOC101341062	LOC101348888	A0A2Y9DHG8	A0A2Y9RFV4	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Vacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family.	0.599
LOC101341062	LOC101350574	A0A2Y9DHG8	A0A2Y9DSZ5	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 1 isoform X1.	0.999
LOC101341062	LOC101355642	A0A2Y9DHG8	A0A2Y9RR46	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Charged multivesicular body protein 2a.	0.970
LOC101341062	LOC101359350	A0A2Y9DHG8	A0A2Y9G4B9	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family.	0.598
LOC101341062	LOC101360847	A0A2Y9DHG8	A0A2Y9DNM8	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.873
LOC101341195	LOC101341062	A0A2Y9RDR0	A0A2Y9DHG8	Tumor susceptibility gene 101 protein isoform X1.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.986
LOC101341195	LOC101344056	A0A2Y9RDR0	A0A2Y9RFN9	Tumor susceptibility gene 101 protein isoform X1.	Lysosome-associated membrane glycoprotein 1 isoform X1.	0.579
LOC101341195	LOC101347681	A0A2Y9RDR0	A0A2Y9R2N6	Tumor susceptibility gene 101 protein isoform X1.	Vacuolar protein sorting-associated protein 4B isoform X1; Belongs to the AAA ATPase family.	0.645
LOC101341195	LOC101348599	A0A2Y9RDR0	A0A2Y9DMI8	Tumor susceptibility gene 101 protein isoform X1.	Programmed cell death 6-interacting protein isoform X1.	0.913
LOC101341195	LOC101348888	A0A2Y9RDR0	A0A2Y9RFV4	Tumor susceptibility gene 101 protein isoform X1.	Vacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family.	0.661
LOC101341195	LOC101349784	A0A2Y9RDR0	A0A2Y9QW53	Tumor susceptibility gene 101 protein isoform X1.	Syntenin-1 isoform X1.	0.524