(19 nodes) Lymph node development network (Trichechus manatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101356545	Roquin-2 isoform X1. (1189 aa)
	LOC101349277	Thymocyte selection-associated high mobility group box protein TOX. (515 aa)
	LOC101342493	Protein spinster homolog 2. (398 aa)
	LOC101360285	Homeobox protein Nkx-2.3. (367 aa)
	LOC101351696	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	LOC101342543	Transforming growth factor beta; Belongs to the TGF-beta family. (392 aa)
	LOC101352734	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (202 aa)
	LOC101359394	Endosialin. (848 aa)
	LOC101341683	Interleukin; Belongs to the IL-15/IL-21 family. (210 aa)
	LOC101348201	C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	LOC101361317	Nuclear receptor ROR-gamma isoform X1. (518 aa)
	LOC101342909	Lymphotoxin-beta isoform X1; Belongs to the tumor necrosis factor family. (244 aa)
	LOC101351100	Interleukin-7 receptor subunit alpha isoform X1. (480 aa)
	LOC101342393	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (205 aa)
	LOC101361676	Adapter protein CIKS. (563 aa)
	LOC101356383	Podoplanin. (162 aa)
	LOC101355445	Tumor necrosis factor receptor superfamily member 11A. (867 aa)
	LOC101355323	LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3. (551 aa)
	LOC101344202	Roquin-1 isoform X1. (1134 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101341683	LOC101342393	A0A2Y9E271	A0A2Y9EBS3	Interleukin; Belongs to the IL-15/IL-21 family.	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	0.435
LOC101341683	LOC101351100	A0A2Y9E271	A0A2Y9RJ93	Interleukin; Belongs to the IL-15/IL-21 family.	Interleukin-7 receptor subunit alpha isoform X1.	0.892
LOC101342393	LOC101341683	A0A2Y9EBS3	A0A2Y9E271	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	Interleukin; Belongs to the IL-15/IL-21 family.	0.435
LOC101342393	LOC101342909	A0A2Y9EBS3	A0A2Y9EBA9	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	Lymphotoxin-beta isoform X1; Belongs to the tumor necrosis factor family.	0.996
LOC101342909	LOC101342393	A0A2Y9EBA9	A0A2Y9EBS3	Lymphotoxin-beta isoform X1; Belongs to the tumor necrosis factor family.	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	0.996
LOC101342909	LOC101355445	A0A2Y9EBA9	A0A2Y9FXT3	Lymphotoxin-beta isoform X1; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 11A.	0.400
LOC101344202	LOC101356545	A0A2Y9QQW7	A0A2Y9QYZ4	Roquin-1 isoform X1.	Roquin-2 isoform X1.	0.533
LOC101348201	LOC101351100	A0A2Y9E3G1	A0A2Y9RJ93	C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family.	Interleukin-7 receptor subunit alpha isoform X1.	0.480
LOC101351100	LOC101341683	A0A2Y9RJ93	A0A2Y9E271	Interleukin-7 receptor subunit alpha isoform X1.	Interleukin; Belongs to the IL-15/IL-21 family.	0.892
LOC101351100	LOC101348201	A0A2Y9RJ93	A0A2Y9E3G1	Interleukin-7 receptor subunit alpha isoform X1.	C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family.	0.480
LOC101352734	LOC101355323	A0A2Y9DZ28	A0A2Y9QHA1	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3.	0.981
LOC101355323	LOC101352734	A0A2Y9QHA1	A0A2Y9DZ28	LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.981
LOC101355445	LOC101342909	A0A2Y9FXT3	A0A2Y9EBA9	Tumor necrosis factor receptor superfamily member 11A.	Lymphotoxin-beta isoform X1; Belongs to the tumor necrosis factor family.	0.400
LOC101356545	LOC101344202	A0A2Y9QYZ4	A0A2Y9QQW7	Roquin-2 isoform X1.	Roquin-1 isoform X1.	0.533