(89 nodes) Negative regulation of inflammatory response network (Trichechus manatus)

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second shell of interactors

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	LOC101358863	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	LOC101352828	Appetite-regulating hormone. (117 aa)
	LOC101356506	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	LOC101345067	Tumor necrosis factor alpha-induced protein 3 isoform X1. (790 aa)
	LOC101360453	12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa)
	LOC101343663	Free fatty acid receptor 4. (361 aa)
	LOC101360898	Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
	LOC101344352	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	LOC101340794	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1013 aa)
	LOC101349602	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
	LOC101351841	Selenoprotein S. (189 aa)
	LOC101341724	Protein NOV homolog. (357 aa)
	LOC101343320	NLR family CARD domain-containing protein 3 isoform X1. (1065 aa)
	LOC101340958	Phospholipase A(2). (161 aa)
	LOC101361934	Insulin-like growth factor I isoform X1. (189 aa)
	LOC101348420	Suppressor of cytokine signaling 3. (228 aa)
	LOC101348760	Granulins. (595 aa)
	LOC101347664	Nuclear receptor ROR-alpha. (386 aa)
	LOC101342743	Interleukin-10. (178 aa)
	LOC101358480	UNC119-binding protein C5orf30 homolog. (207 aa)
	LOC101349794	Tumor necrosis factor-inducible gene 6 protein. (277 aa)
	LOC101355952	Retinoblastoma-associated protein isoform X3. (938 aa)
	LOC101361863	Forkhead box protein P3 isoform X1. (429 aa)
	LOC101341575	Acid sphingomyelinase-like phosphodiesterase 3b. (494 aa)
	LOC101341484	Fibronectin type III domain-containing protein 4. (230 aa)
	LOC101343255	WAP four-disulfide core domain protein 1. (200 aa)
	LOC101360149	Nuclear receptor subfamily 1 group D member 1. (611 aa)
	LOC101351068	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (404 aa)
	LOC101349207	Peroxisome proliferator-activated receptor alpha. (468 aa)
	LOC101351866	Nuclear factor NF-kappa-B p105 subunit isoform X1. (997 aa)
	LOC101344799	Hepatocyte growth factor isoform X1; Belongs to the peptidase S1 family. (819 aa)
	LOC101350732	NACHT, LRR and PYD domains-containing protein 12 isoform X1. (1055 aa)
	LOC101356323	Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (323 aa)
	LOC101352214	Adiponectin. (244 aa)
	LOC101341421	Malignant fibrous histiocytoma-amplified sequence 1 isoform X1. (1052 aa)
	LOC101355125	Adipolin. (305 aa)
	LOC101341010	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (139 aa)
	LOC101345144	Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
	LOC101352305	ARF GTPase-activating protein GIT1 isoform X1. (708 aa)
	LOC101355130	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	LOC101341268	Acyloxyacyl hydrolase isoform X1. (575 aa)
	LOC101360180	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (174 aa)
	LOC101349839	Vitamin K-dependent protein C. (450 aa)
	LOC101358882	Lysophospholipid acyltransferase 5 isoform X1; Belongs to the membrane-bound acyltransferase family. (487 aa)
	LOC101350602	Uracil nucleotide/cysteinyl leukotriene receptor; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	LOC101348724	Histone-lysine N-methyltransferase ASH1L isoform X1. (2963 aa)
	LOC101345496	Arachidonate 5-lipoxygenase. (625 aa)
	LOC101347879	Synaptotagmin-11. (431 aa)
	LOC101348725	C-X-C motif chemokine 17. (121 aa)
	LOC101342966	5'-nucleotidase isoform X1; Belongs to the 5'-nucleotidase family. (574 aa)
	LOC101343402	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	LOC101349502	NACHT, LRR and PYD domains-containing protein 6. (890 aa)
	LOC101346624	Tumor necrosis factor alpha-induced protein 8-like protein 2. (184 aa)
	LOC101357350	SLAM family member 8. (296 aa)
	LOC101360550	Peroxisome proliferator-activated receptor delta. (441 aa)
	LOC101345689	Cis-aconitate decarboxylase. (473 aa)
	LOC101357691	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
	LOC105756153	OX-2 membrane glycoprotein-like. (307 aa)
	LOC101358741	Bile acid receptor. (364 aa)
	LOC101357593	Probable E3 ubiquitin-protein ligase makorin-2 isoform X1. (416 aa)
	LOC101352858	Fractalkine isoform X1. (422 aa)
	LOC101346946	Breakpoint cluster region protein. (840 aa)
	LOC101346964	Tyrosine-protein phosphatase non-receptor type. (416 aa)
	LOC101347566	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform X1. (753 aa)
	LOC101340355	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (953 aa)
	LOC101357884	Tumor necrosis factor receptor superfamily member 1B isoform X1. (458 aa)
	LOC101356110	Pyrin isoform X1. (712 aa)
	LOC101352444	OX-2 membrane glycoprotein isoform X1. (337 aa)
	LOC101342003	Low-density lipoprotein receptor. (866 aa)
	LOC101354015	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (447 aa)
	LOC101349132	LOW QUALITY PROTEIN: protein FAM19A3. (168 aa)
	LOC101344029	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	LOC101357794	G protein pathway suppressor 2 isoform X1. (369 aa)
	LOC101344711	cystatin-F. (145 aa)
	LOC101347166	Nuclear receptor subfamily 1 group D member 2 isoform X1. (494 aa)
	LOC101345297	Rab5 GDP/GTP exchange factor isoform X1. (492 aa)
	LOC101355538	Interleukin-20 receptor subunit beta. (263 aa)
	LOC101348056	Suppressor of cytokine signaling 5. (537 aa)
	LOC101358598	NEDD4 family-interacting protein 1 isoform X1. (224 aa)
	LOC101352286	Tyrosine-protein kinase receptor TYRO3. (1053 aa)
	LOC101352736	Ubiquitin thioesterase otulin isoform X1. (298 aa)
	LOC101341264	Interleukin-13. (135 aa)
	LOC101352422	Proteasome subunit alpha type. (263 aa)
	LOC101351984	Adenosine deaminase-like. (250 aa)
	LOC101346264	Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	LOC101343372	NLR family member X1 isoform X1. (975 aa)
	LOC101352502	Adenosine deaminase. (396 aa)
	LOC101341867	Tumor necrosis factor receptor superfamily member 1A. (453 aa)
	LOC101359497	Sharpin. (408 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340355	LOC101340794	A0A2Y9QLA4	A0A2Y9DBN9	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1.	0.530
LOC101340355	LOC101341867	A0A2Y9QLA4	A0A2Y9RZR5	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Tumor necrosis factor receptor superfamily member 1A.	0.975
LOC101340355	LOC101351866	A0A2Y9QLA4	A0A2Y9DTW8	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.468
LOC101340355	LOC101352286	A0A2Y9QLA4	A0A2Y9RH27	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Tyrosine-protein kinase receptor TYRO3.	0.454
LOC101340355	LOC101352736	A0A2Y9QLA4	A0A2Y9RI97	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Ubiquitin thioesterase otulin isoform X1.	0.567
LOC101340355	LOC101359497	A0A2Y9QLA4	A0A2Y9S016	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	Sharpin.	0.691
LOC101340794	LOC101340355	A0A2Y9DBN9	A0A2Y9QLA4	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1.	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family.	0.530
LOC101340794	LOC101345067	A0A2Y9DBN9	A0A2Y9D6Y5	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1.	Tumor necrosis factor alpha-induced protein 3 isoform X1.	0.477
LOC101340794	LOC101351866	A0A2Y9DBN9	A0A2Y9DTW8	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.400
LOC101340794	LOC101359497	A0A2Y9DBN9	A0A2Y9S016	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1.	Sharpin.	0.470
LOC101340958	LOC101345496	A0A2Y9DF84	A0A2Y9E7Z6	Phospholipase A(2).	Arachidonate 5-lipoxygenase.	0.688
LOC101341010	LOC101341264	A0A2Y9E0J2	A0A2Y9RJZ5	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Interleukin-13.	0.745
LOC101341010	LOC101342743	A0A2Y9E0J2	A0A2Y9DIE0	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Interleukin-10.	0.719
LOC101341010	LOC101348056	A0A2Y9E0J2	A0A2Y9RCI0	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Suppressor of cytokine signaling 5.	0.448
LOC101341010	LOC101348420	A0A2Y9E0J2	A0A2Y9DGD0	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Suppressor of cytokine signaling 3.	0.444
LOC101341010	LOC101352858	A0A2Y9E0J2	A0A2Y9FYA6	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Fractalkine isoform X1.	0.403
LOC101341010	LOC101354015	A0A2Y9E0J2	A0A2Y9R3R7	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.596
LOC101341010	LOC101355538	A0A2Y9E0J2	A0A2Y9RBF1	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Interleukin-20 receptor subunit beta.	0.663
LOC101341010	LOC101356506	A0A2Y9E0J2	A0A2Y9D5X7	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.402
LOC101341010	LOC101360180	A0A2Y9E0J2	A0A2Y9E495	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.860