(26 nodes) Negative regulation of B cell activation network (Trichechus manatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101342743	Interleukin-10. (178 aa)
	LOC101355206	Serine-protein kinase ATM isoform X1. (2331 aa)
	LOC101361885	Tyrosine-protein kinase. (508 aa)
	LOC101344655	Carabin isoform X1. (452 aa)
	LOC101351339	B-cell scaffold protein with ankyrin repeats isoform X1. (480 aa)
	LOC101358598	NEDD4 family-interacting protein 1 isoform X1. (224 aa)
	LOC111821221	B-cell scaffold protein with ankyrin repeats-like isoform X1. (264 aa)
	LOC101356880	Tyrosine-protein kinase. (686 aa)
	LOC101355321	SAM domain-containing protein SAMSN-1. (373 aa)
	LOC101357366	CMRF35-like molecule 8 isoform X1. (377 aa)
	LOC101344202	Roquin-1 isoform X1. (1134 aa)
	LOC101347479	Serine/threonine-protein kinase N1. (951 aa)
	LOC101350772	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1354 aa)
	LOC101341542	THO complex subunit 1. (657 aa)
	LOC101341939	PRKC apoptosis WT1 regulator protein. (338 aa)
	LOC101350478	B-cell lymphoma 6 protein. (706 aa)
	LOC101341665	Tumor necrosis factor receptor superfamily member 13B. (300 aa)
	LOC101347470	Poly [ADP-ribose] polymerase. (536 aa)
	LOC101345067	Tumor necrosis factor alpha-induced protein 3 isoform X1. (790 aa)
	LOC101353037	Tyrosine-protein kinase. (512 aa)
	LOC101355085	Forkhead box protein J1. (418 aa)
	LOC111821652	Serine-protein kinase ATM-like; Belongs to the PI3/PI4-kinase family. (700 aa)
	LOC101361863	Forkhead box protein P3 isoform X1. (429 aa)
	LOC101351858	Cytotoxic T-lymphocyte protein 4 isoform X1. (222 aa)
	LOC101349550	Tumor necrosis factor receptor superfamily member 21. (657 aa)
	LOC101346535	TYRO protein tyrosine kinase-binding protein. (118 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101342743	LOC101351858	A0A2Y9DIE0	A0A2Y9DP48	Interleukin-10.	Cytotoxic T-lymphocyte protein 4 isoform X1.	0.596
LOC101342743	LOC101361863	A0A2Y9DIE0	A0A2Y9DLG9	Interleukin-10.	Forkhead box protein P3 isoform X1.	0.674
LOC101345067	LOC101361885	A0A2Y9D6Y5	A0A2Y9RLV2	Tumor necrosis factor alpha-induced protein 3 isoform X1.	Tyrosine-protein kinase.	0.458
LOC101346535	LOC101350772	A0A2Y9RWT1	A0A2Y9QLZ4	TYRO protein tyrosine kinase-binding protein.	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1.	0.604
LOC101346535	LOC101353037	A0A2Y9RWT1	A0A2Y9DEI9	TYRO protein tyrosine kinase-binding protein.	Tyrosine-protein kinase.	0.425
LOC101346535	LOC101356880	A0A2Y9RWT1	A0A2Y9QXP6	TYRO protein tyrosine kinase-binding protein.	Tyrosine-protein kinase.	0.487
LOC101346535	LOC101357366	A0A2Y9RWT1	A0A2Y9QSP6	TYRO protein tyrosine kinase-binding protein.	CMRF35-like molecule 8 isoform X1.	0.509
LOC101350478	LOC101351858	A0A2Y9DXA5	A0A2Y9DP48	B-cell lymphoma 6 protein.	Cytotoxic T-lymphocyte protein 4 isoform X1.	0.443
LOC101350478	LOC101361863	A0A2Y9DXA5	A0A2Y9DLG9	B-cell lymphoma 6 protein.	Forkhead box protein P3 isoform X1.	0.655
LOC101350772	LOC101346535	A0A2Y9QLZ4	A0A2Y9RWT1	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1.	TYRO protein tyrosine kinase-binding protein.	0.604
LOC101350772	LOC101353037	A0A2Y9QLZ4	A0A2Y9DEI9	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1.	Tyrosine-protein kinase.	0.748
LOC101350772	LOC101356880	A0A2Y9QLZ4	A0A2Y9QXP6	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1.	Tyrosine-protein kinase.	0.437
LOC101351339	LOC101353037	A0A2Y9RFZ8	A0A2Y9DEI9	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein kinase.	0.474
LOC101351339	LOC101361885	A0A2Y9RFZ8	A0A2Y9RLV2	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein kinase.	0.580
LOC101351339	LOC111821221	A0A2Y9RFZ8	A0A2Y9R4U5	B-cell scaffold protein with ankyrin repeats isoform X1.	B-cell scaffold protein with ankyrin repeats-like isoform X1.	0.922
LOC101351858	LOC101342743	A0A2Y9DP48	A0A2Y9DIE0	Cytotoxic T-lymphocyte protein 4 isoform X1.	Interleukin-10.	0.596
LOC101351858	LOC101350478	A0A2Y9DP48	A0A2Y9DXA5	Cytotoxic T-lymphocyte protein 4 isoform X1.	B-cell lymphoma 6 protein.	0.443
LOC101351858	LOC101353037	A0A2Y9DP48	A0A2Y9DEI9	Cytotoxic T-lymphocyte protein 4 isoform X1.	Tyrosine-protein kinase.	0.424
LOC101351858	LOC101361863	A0A2Y9DP48	A0A2Y9DLG9	Cytotoxic T-lymphocyte protein 4 isoform X1.	Forkhead box protein P3 isoform X1.	0.677
LOC101353037	LOC101346535	A0A2Y9DEI9	A0A2Y9RWT1	Tyrosine-protein kinase.	TYRO protein tyrosine kinase-binding protein.	0.425