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LOC101346628 LOC101346628 LOC101359681 LOC101359681 LOC101361476 LOC101361476 LOC101358108 LOC101358108 LOC101352834 LOC101352834 LOC101354218 LOC101354218 LOC101361135 LOC101361135 LOC101346178 LOC101346178 LOC101356696 LOC101356696 LOC101359870 LOC101359870 LOC101341710 LOC101341710 LOC101354739 LOC101354739 LOC101354907 LOC101354907 LOC101350626 LOC101350626 LOC101350877 LOC101350877 LOC101347238 LOC101347238 LOC101354917 LOC101354917 LOC101354066 LOC101354066 LOC101358475 LOC101358475 LOC101361596 LOC101361596 LOC101348677 LOC101348677 LOC101346046 LOC101346046 LOC101340968 LOC101340968 LOC101346735 LOC101346735 LOC101356379 LOC101356379 LOC101360757 LOC101360757 LOC101352949 LOC101352949 LOC101342383 LOC101342383 LOC101342478 LOC101342478 LOC101353745 LOC101353745 LOC101343698 LOC101343698 LOC101359801 LOC101359801 LOC101343239 LOC101343239 LOC101361085 LOC101361085 LOC101348406 LOC101348406 LOC101358029 LOC101358029 LOC101351030 LOC101351030 LOC101348403 LOC101348403 LOC101356763 LOC101356763 LOC101346960 LOC101346960 LOC101353605 LOC101353605 LOC101348388 LOC101348388 LOC101357672 LOC101357672 LOC101344171 LOC101344171 LOC101347623 LOC101347623 LOC105756737 LOC105756737 LOC101359583 LOC101359583 LOC101360961 LOC101360961 LOC101348229 LOC101348229 LOC101352238 LOC101352238 LOC101353721 LOC101353721 LOC101340883 LOC101340883 LOC101349090 LOC101349090 LOC101341727 LOC101341727 LOC101352856 LOC101352856 LOC101343894 LOC101343894 LOC101353004 LOC101353004 LOC101348709 LOC101348709 LOC101353181 LOC101353181 LOC101349569 LOC101349569 LOC101354027 LOC101354027 LOC101348287 LOC101348287 LOC101353508 LOC101353508 LOC101358685 LOC101358685 LOC101360861 LOC101360861 LOC101340652 LOC101340652 LOC101353329 LOC101353329 LOC101341850 LOC101341850 LOC101346760 LOC101346760 LOC101344394 LOC101344394 LOC101348016 LOC101348016 LOC101348447 LOC101348447 LOC101354347 LOC101354347 LOC101351605 LOC101351605 LOC101343788 LOC101343788 LOC101342200 LOC101342200 LOC101345830 LOC101345830 LOC111822375 LOC111822375 LOC101348808 LOC101348808 LOC101355374 LOC101355374 LOC101356759 LOC101356759 LOC101342174 LOC101342174 LOC101344874 LOC101344874 LOC101354765 LOC101354765 LOC101360938 LOC101360938 LOC101358502 LOC101358502 LOC101345214 LOC101345214 LOC101353820 LOC101353820 LOC101362036 LOC101362036 LOC101354264 LOC101354264 LOC101359893 LOC101359893 LOC101351331 LOC101351331 LOC101349544 LOC101349544 LOC101357042 LOC101357042 LOC101357041 LOC101357041 LOC101340529 LOC101340529 LOC101358217 LOC101358217 LOC101342730 LOC101342730 LOC101347393 LOC101347393 LOC101347992 LOC101347992 LOC105755970 LOC105755970 LOC101352830 LOC101352830 LOC101360573 LOC101360573 LOC101355865 LOC101355865 LOC101349939 LOC101349939 LOC101352268 LOC101352268 LOC101361256 LOC101361256 LOC101356128 LOC101356128 LOC101356120 LOC101356120 LOC101346574 LOC101346574 LOC101349196 LOC101349196 LOC101360311 LOC101360311 LOC101346581 LOC101346581 LOC101361352 LOC101361352 LOC111820564 LOC111820564 LOC101360589 LOC101360589 LOC101349552 LOC101349552 LOC101356391 LOC101356391 LOC101350643 LOC101350643 LOC101340462 LOC101340462 LOC101357600 LOC101357600 LOC101352808 LOC101352808 LOC101361692 LOC101361692 LOC101347263 LOC101347263 LOC101346075 LOC101346075 LOC101358847 LOC101358847 LOC101358519 LOC101358519 LOC101346417 LOC101346417 LOC101357828 LOC101357828 LOC101359429 LOC101359429
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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LOC101346628tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (512 aa)
LOC101359681Ribonuclease P protein subunit p30. (268 aa)
LOC101361476prolyl-tRNA synthetase associated domain-containing protein 1. (171 aa)
LOC101358108THUMP domain-containing protein 2 isoform X1. (511 aa)
LOC101352834Ribonuclease P protein subunit p14. (127 aa)
LOC101354218glutamine--tRNA ligase isoform X2; Belongs to the class-I aminoacyl-tRNA synthetase family. (775 aa)
LOC101361135Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (903 aa)
LOC101346178THUMP domain-containing protein 3. (504 aa)
LOC101356696Ribonucleases P/MRP protein subunit POP1. (1018 aa)
LOC101359870Alpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (505 aa)
LOC101341710Nucleic acid dioxygenase ALKBH1. (389 aa)
LOC101354739Tyrosine--tRNA ligase. (528 aa)
LOC101354907tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (467 aa)
LOC101350626Probable proline--tRNA ligase, mitochondrial. (475 aa)
LOC101350877Probable threonine--tRNA ligase 2, cytoplasmic. (799 aa)
LOC101347238tRNA wybutosine-synthesizing protein 2 homolog. (439 aa)
LOC101354917Probable glutamate--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (535 aa)
LOC101354066Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (415 aa)
LOC101358475Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (380 aa)
LOC101361596methionyl-tRNA formyltransferase, mitochondrial isoform X1. (394 aa)
LOC101348677aspartate--tRNA ligase, cytoplasmic isoform X1. (501 aa)
LOC101346046Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (407 aa)
LOC101340968Probable peptidyl-tRNA hydrolase. (215 aa)
LOC101346735isoleucine--tRNA ligase, mitochondrial. (1012 aa)
LOC101356379phenylalanine--tRNA ligase beta subunit. (589 aa)
LOC101360757Putative D-tyrosyl-tRNA(Tyr) deacylase 2 isoform X1. (168 aa)
LOC101352949tRNA (guanine(26)-N(2))-dimethyltransferase. (616 aa)
LOC101342383phenylalanine--tRNA ligase alpha subunit. (508 aa)
LOC101342478TRMT1-like protein isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (790 aa)
LOC101353745LOW QUALITY PROTEIN: ribonuclease P protein subunit p30-like. (333 aa)
LOC101343698tRNA (Uracil(54)-C(5))-methyltransferase homolog; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (496 aa)
LOC101359801tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like. (474 aa)
LOC101343239aspartate--tRNA ligase, mitochondrial. (654 aa)
LOC101361085Ribonuclease P protein subunit p25. (202 aa)
LOC101348406valine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1264 aa)
LOC101358029alanyl-tRNA editing protein Aarsd1 isoform X1. (412 aa)
LOC101351030tRNA (Uracil-5-)-methyltransferase homolog A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (614 aa)
LOC101348403valine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1061 aa)
LOC101356763tRNA wybutosine-synthesizing protein 3 homolog isoform X1. (258 aa)
LOC101346960Probable arginine--tRNA ligase, mitochondrial isoform X1; Belongs to the class-I aminoacyl-tRNA synthetase family. (578 aa)
LOC101353605serine--tRNA ligase, mitochondrial. (511 aa)
LOC101348388Lysine--tRNA ligase. (625 aa)
LOC101357672pre-miRNA 5'-monophosphate methyltransferase. (293 aa)
LOC101344171alanine--tRNA ligase, cytoplasmic isoform X1; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
LOC101347623Ribonuclease P protein subunit p21 isoform X1. (175 aa)
LOC105756737LYR motif-containing protein 9; Belongs to the complex I LYR family. (47 aa)
LOC101359583Ribonuclease P protein subunit p40 isoform X1. (363 aa)
LOC101360961DTW domain-containing protein 1. (304 aa)
LOC101348229cysteine--tRNA ligase, cytoplasmic isoform X1. (753 aa)
LOC101352238threonine--tRNA ligase, mitochondrial isoform X2. (715 aa)
LOC101353721Tyrosine--tRNA ligase. (479 aa)
LOC101340883tRNA (Cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (338 aa)
LOC101349090Ribonuclease P protein subunit p29. (177 aa)
LOC101341727Phosphatidylinositol-glycan biosynthesis class X protein. (235 aa)
LOC101352856tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1. (521 aa)
LOC101343894threonine--tRNA ligase, cytoplasmic. (723 aa)
LOC101353004tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (413 aa)
LOC101348709tRNA:m(4)X modification enzyme TRM13 homolog isoform X1. (481 aa)
LOC101353181Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (286 aa)
LOC101349569leucine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (1176 aa)
LOC101354027tRNA 2'-phosphotransferase 1. (253 aa)
LOC101348287Transmembrane protein 179B. (219 aa)
LOC101353508Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (688 aa)
LOC101358685Probable tRNA (Uracil-O(2)-)-methyltransferase isoform X1. (747 aa)
LOC101360861Alkylated DNA repair protein alkB homolog 8 isoform X1. (663 aa)
LOC101340652Probable tRNA methyltransferase 9-like protein isoform X1. (452 aa)
LOC101353329tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (317 aa)
LOC101341850tRNA (Guanine(10)-N2)-methyltransferase homolog isoform X1. (460 aa)
LOC101346760Probable asparagine--tRNA ligase, mitochondrial isoform X1. (477 aa)
LOC101344394S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase isoform X1. (731 aa)
LOC101348016Putative methyltransferase NSUN6 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (469 aa)
LOC101348447histidine--tRNA ligase, cytoplasmic isoform X1. (509 aa)
LOC101354347tRNA wybutosine-synthesizing protein 4. (686 aa)
LOC101351605tRNA (Cytosine(38)-C(5))-methyltransferase isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (320 aa)
LOC101343788Mitochondrial tRNA-specific 2-thiouridylase 1. (417 aa)
LOC101342200phenylalanine--tRNA ligase, mitochondrial. (485 aa)
LOC101345830Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
LOC111822375tRNA-splicing endonuclease subunit Sen2-like. (123 aa)
LOC101348808serine--tRNA ligase, cytoplasmic isoform X2. (539 aa)
LOC101355374isoleucine--tRNA ligase, cytoplasmic isoform X1; Belongs to the class-I aminoacyl-tRNA synthetase family. (1262 aa)
LOC101356759tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (460 aa)
LOC101342174asparagine--tRNA ligase, cytoplasmic. (559 aa)
LOC101344874alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (985 aa)
LOC101354765tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (277 aa)
LOC101360938methionine--tRNA ligase, cytoplasmic isoform X1; Belongs to the class-I aminoacyl-tRNA synthetase family. (958 aa)
LOC101358502Zinc phosphodiesterase ELAC protein 1. (363 aa)
LOC101345214tRNA pseudouridine(38/39) synthase. (479 aa)
LOC101353820Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (403 aa)
LOC101362036Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (200 aa)
LOC101354264tRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (671 aa)
LOC101359893methionine--tRNA ligase, mitochondrial isoform X1; Belongs to the class-I aminoacyl-tRNA synthetase family. (593 aa)
LOC101351331tRNA methyltransferase 10 homolog C. (424 aa)
LOC101349544glycine--tRNA ligase. (744 aa)
LOC101357042tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (284 aa)
LOC101357041D-aminoacyl-tRNA deacylase. (209 aa)
LOC101340529tRNA (Adenine(37)-N6)-methyltransferase isoform X1. (518 aa)
LOC101358217tRNA-splicing endonuclease subunit Sen54. (424 aa)
LOC101342730tRNA methyltransferase 10 homolog B isoform X1. (316 aa)
LOC101347393LOW QUALITY PROTEIN: ribonuclease P protein subunit p21. (191 aa)
LOC101347992Probable methyltransferase TARBP1 isoform X1. (1621 aa)
LOC105755970Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial. (106 aa)
LOC101352830DALR anticodon-binding domain-containing protein 3 isoform X1. (555 aa)
LOC101360573L-seryl-tRNA(Sec) kinase. (359 aa)
LOC101355865Mitochondrial ribonuclease P catalytic subunit. (583 aa)
LOC101349939Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (630 aa)
LOC101352268tryptophan--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (475 aa)
LOC101361256O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (555 aa)
LOC101356128peptidyl-tRNA hydrolase 2, mitochondrial. (300 aa)
LOC101356120LOW QUALITY PROTEIN: bifunctional glutamate/proline--tRNA ligase. (1407 aa)
LOC101346574DTW domain-containing protein 2. (303 aa)
LOC101349196Zinc phosphodiesterase ELAC protein 2. (818 aa)
LOC101360311peptidyl-tRNA hydrolase ICT1, mitochondrial isoform X3. (230 aa)
LOC101346581Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. (574 aa)
LOC101361352tRNA (Adenine(58)-N(1))-methyltransferase, mitochondrial. (467 aa)
LOC111820564Small integral membrane protein 26-like. (94 aa)
LOC101360589Ribonuclease P protein subunit p38. (284 aa)
LOC101349552Probable histidine--tRNA ligase, mitochondrial isoform X1. (521 aa)
LOC101356391tRNA methyltransferase 10 homolog A isoform X1. (421 aa)
LOC101350643Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (379 aa)
LOC101340462Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family. (142 aa)
LOC101357600Putative tRNA pseudouridine synthase Pus10 isoform X1. (529 aa)
LOC101352808tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (318 aa)
LOC101361692tRNA wybutosine-synthesizing protein 5 isoform X1. (337 aa)
LOC101347263tRNA (Cytosine(34)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (743 aa)
LOC101346075Probable cysteine--tRNA ligase, mitochondrial isoform X1. (575 aa)
LOC101358847tryptophan--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
LOC101358519Leucine-rich repeat-containing protein 47. (433 aa)
LOC101346417Threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1. (578 aa)
LOC101357828tRNA pseudouridine synthase A isoform X1. (433 aa)
LOC101359429arginine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (660 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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