5 items (Trichechus manatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LOC101353068	Tubby-like protein; Belongs to the TUB family. (464 aa)
	LOC101348995	cAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
	LOC101356905	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (529 aa)
	LOC101354554	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
	LOC101342638	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101342638	LOC101348995	A0A2Y9D7C8	A0A2Y9QFS5	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha.	0.900
LOC101342638	LOC101354554	A0A2Y9D7C8	A0A2Y9D8U4	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.678
LOC101342638	LOC101356905	A0A2Y9D7C8	A0A2Y9DZC4	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.627
LOC101348995	LOC101342638	A0A2Y9QFS5	A0A2Y9D7C8	cAMP-dependent protein kinase catalytic subunit alpha.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.900
LOC101348995	LOC101354554	A0A2Y9QFS5	A0A2Y9D8U4	cAMP-dependent protein kinase catalytic subunit alpha.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.678
LOC101348995	LOC101356905	A0A2Y9QFS5	A0A2Y9DZC4	cAMP-dependent protein kinase catalytic subunit alpha.	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.627
LOC101353068	LOC101356905	A0A2Y9RD73	A0A2Y9DZC4	Tubby-like protein; Belongs to the TUB family.	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.718
LOC101354554	LOC101342638	A0A2Y9D8U4	A0A2Y9D7C8	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.678
LOC101354554	LOC101348995	A0A2Y9D8U4	A0A2Y9QFS5	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	cAMP-dependent protein kinase catalytic subunit alpha.	0.678
LOC101354554	LOC101356905	A0A2Y9D8U4	A0A2Y9DZC4	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.567
LOC101356905	LOC101342638	A0A2Y9DZC4	A0A2Y9D7C8	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.627
LOC101356905	LOC101348995	A0A2Y9DZC4	A0A2Y9QFS5	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	cAMP-dependent protein kinase catalytic subunit alpha.	0.627
LOC101356905	LOC101353068	A0A2Y9DZC4	A0A2Y9RD73	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	Tubby-like protein; Belongs to the TUB family.	0.718
LOC101356905	LOC101354554	A0A2Y9DZC4	A0A2Y9D8U4	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.567