(17 nodes) Regulation of bicellular tight junction assembly network (Trichechus manatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	LOC101342326	Unconventional myosin-Ic; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
	TNF	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (234 aa)
	LOC101358905	Junctional adhesion molecule A. (298 aa)
	LOC111819053	Rho-associated protein kinase 1-like. (93 aa)
	LOC101343223	Rho-associated protein kinase 1 isoform X1. (959 aa)
	LOC101345851	Zinc finger protein SNAI1. (266 aa)
	LOC101346027	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (406 aa)
	LOC101358445	interleukin-17A. (153 aa)
	LOC101350336	LOW QUALITY PROTEIN: nephrocystin-4. (1422 aa)
	LOC101349039	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	LOC101351454	Nephrocystin-1. (688 aa)
	LOC101345704	Zinc finger protein SNAI2. (268 aa)
	LOC101355264	Ephrin type-A receptor 2. (977 aa)
	LOC111822717	Rho-associated protein kinase 1. (88 aa)
	LOC101351256	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	LOC101343250	G-protein coupled bile acid receptor 1. (330 aa)
	LOC101345959	Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1405 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101343223	LOC101345959	A0A2Y9QG20	A0A2Y9QPS9	Rho-associated protein kinase 1 isoform X1.	Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.676
LOC101343223	LOC111819053	A0A2Y9QG20	A0A2Y9QMQ5	Rho-associated protein kinase 1 isoform X1.	Rho-associated protein kinase 1-like.	0.488
LOC101343250	LOC101351454	A0A2Y9R667	A0A2Y9D7U4	G-protein coupled bile acid receptor 1.	Nephrocystin-1.	0.491
LOC101345704	LOC101345851	A0A2Y9DJ46	A0A2Y9G1U3	Zinc finger protein SNAI2.	Zinc finger protein SNAI1.	0.452
LOC101345851	LOC101345704	A0A2Y9G1U3	A0A2Y9DJ46	Zinc finger protein SNAI1.	Zinc finger protein SNAI2.	0.452
LOC101345959	LOC101343223	A0A2Y9QPS9	A0A2Y9QG20	Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase 1 isoform X1.	0.676
LOC101345959	LOC111819053	A0A2Y9QPS9	A0A2Y9QMQ5	Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase 1-like.	0.670
LOC101345959	LOC111822717	A0A2Y9QPS9	A0A2Y9S0G2	Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase 1.	0.676
LOC101346027	LOC101349039	A0A2Y9EAF9	A0A2Y9DXA2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.759
LOC101346027	LOC101358905	A0A2Y9EAF9	A0A2Y9QP03	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Junctional adhesion molecule A.	0.639
LOC101349039	LOC101346027	A0A2Y9DXA2	A0A2Y9EAF9	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.759
LOC101349039	LOC101355264	A0A2Y9DXA2	A0A2Y9DM78	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Ephrin type-A receptor 2.	0.571
LOC101349039	LOC101358905	A0A2Y9DXA2	A0A2Y9QP03	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Junctional adhesion molecule A.	0.702
LOC101350336	LOC101351454	A0A2Y9E107	A0A2Y9D7U4	LOW QUALITY PROTEIN: nephrocystin-4.	Nephrocystin-1.	0.966
LOC101351256	TNF	A0A2Y9RFY1	A0A2Y9QPJ3	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family.	0.973
LOC101351454	LOC101343250	A0A2Y9D7U4	A0A2Y9R667	Nephrocystin-1.	G-protein coupled bile acid receptor 1.	0.491
LOC101351454	LOC101350336	A0A2Y9D7U4	A0A2Y9E107	Nephrocystin-1.	LOW QUALITY PROTEIN: nephrocystin-4.	0.966
LOC101355264	LOC101349039	A0A2Y9DM78	A0A2Y9DXA2	Ephrin type-A receptor 2.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.571
LOC101358445	TNF	A0A2Y9E858	A0A2Y9QPJ3	interleukin-17A.	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family.	0.642
LOC101358905	LOC101346027	A0A2Y9QP03	A0A2Y9EAF9	Junctional adhesion molecule A.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.639