(78 nodes) RHOC GTPase cycle network (Trichechus manatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101354923	Serine/threonine-protein kinase N3 isoform X1. (889 aa)
	LOC101359092	A-kinase anchor protein 13 isoform X1. (2847 aa)
	LOC101345959	Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1405 aa)
	LOC101356266	Rho GTPase-activating protein 18. (657 aa)
	LOC101342647	Rho guanine nucleotide exchange factor 40. (1333 aa)
	LOC111819053	Rho-associated protein kinase 1-like. (93 aa)
	LOC101347479	Serine/threonine-protein kinase N1. (951 aa)
	LOC101343223	Rho-associated protein kinase 1 isoform X1. (959 aa)
	LOC101353444	Rho GTPase-activating protein 39. (1133 aa)
	LOC101354954	Protein-glutamine gamma-glutamyltransferase E. (687 aa)
	LOC101361023	Proto-oncogene DBL. (997 aa)
	LOC101355667	Junction plakoglobin. (745 aa)
	LOC101355462	Protein-glutamine gamma-glutamyltransferase 6. (723 aa)
	LOC101340830	Rho GTPase-activating protein 32 isoform X2. (2101 aa)
	LOC101346946	Breakpoint cluster region protein. (840 aa)
	LOC101360978	STE20-like serine/threonine-protein kinase isoform X1. (1241 aa)
	LOC101345369	Macoilin. (487 aa)
	LOC101342389	Caveolae-associated protein 1. (378 aa)
	LOC101341887	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	LOC101345849	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	LOC101358704	Rac GTPase-activating protein 1. (633 aa)
	LOC101354226	Basal cell adhesion molecule. (588 aa)
	LOC101341786	Ras GTPase-activating-like protein IQGAP3. (1632 aa)
	LOC101343550	Guanine nucleotide exchange factor VAV2. (839 aa)
	LOC101356590	Formin-like protein 3. (976 aa)
	LOC101361215	Oligodendrocyte transcription factor 1. (348 aa)
	LOC101347213	Rho GTPase-activating protein 1 isoform X1. (439 aa)
	LOC101342621	Cell surface glycoprotein MUC18. (651 aa)
	LOC101355472	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	LOC101341682	Anillin. (1128 aa)
	LOC101361633	Syntaxin-5 isoform X1; Belongs to the syntaxin family. (355 aa)
	LOC101355456	LOW QUALITY PROTEIN: probable guanine nucleotide exchange factor MCF2L2. (1278 aa)
	LOC101361887	Rho GTPase-activating protein 7 isoform X1. (1524 aa)
	LOC101354281	Rho guanine nucleotide exchange factor 5. (1605 aa)
	LOC101353506	Rho guanine nucleotide exchange factor 17. (2066 aa)
	LOC101340735	Rho GTPase-activating protein 35. (1501 aa)
	LOC101341495	Vang-like protein. (524 aa)
	LOC101351692	Oligophrenin-1. (803 aa)
	LOC101346061	Disheveled-associated activator of morphogenesis 2 isoform X1. (1067 aa)
	LOC101357892	Rho guanine nucleotide exchange factor 25 isoform X1. (619 aa)
	LOC101343440	RING finger and transmembrane domain-containing protein 2. (451 aa)
	LOC101360937	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2069 aa)
	LOC101348011	ATP-binding cassette sub-family D member 3 isoform X1. (659 aa)
	LOC101360492	Rho GTPase-activating protein 5. (1503 aa)
	LOC101344213	Active breakpoint cluster region-related protein isoform X1. (1189 aa)
	LOC101342480	Rho guanine nucleotide exchange factor 10. (1207 aa)
	LOC101340368	Rho guanine nucleotide exchange factor 28. (1404 aa)
	LOC101356867	DEP domain-containing protein 1B isoform X1. (502 aa)
	LOC101347746	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	LOC101353722	Serine/threonine-protein kinase 10. (967 aa)
	LOC101342810	Disheveled-associated activator of morphogenesis 1. (1069 aa)
	LOC101349168	Vesicle-associated membrane protein-associated protein B/C. (243 aa)
	LOC101346791	Rhotekin isoform X1. (564 aa)
	LOC101345323	Oligodendrocyte transcription factor 3. (272 aa)
	LOC101360283	Rho guanine nucleotide exchange factor 1 isoform X1. (968 aa)
	LOC111822717	Rho-associated protein kinase 1. (88 aa)
	LOC101360964	LOW QUALITY PROTEIN: oligodendrocyte transcription factor 2. (311 aa)
	LOC101350614	Rho guanine nucleotide exchange factor 11. (1304 aa)
	LOC101350357	Coiled-coil domain-containing protein 187. (883 aa)
	LOC101345823	Vesicle-associated membrane protein 3. (111 aa)
	LOC101350331	Unconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1985 aa)
	LOC101349319	stAR-related lipid transfer protein 13. (998 aa)
	LOC101358090	Rho guanine nucleotide exchange factor 12 isoform X1. (1550 aa)
	LOC101343275	Guanine nucleotide exchange factor DBS isoform X7. (1190 aa)
	LOC101359990	Rho GTPase-activating protein 26 isoform X1. (770 aa)
	LOC101342382	Rhotekin-2. (528 aa)
	LOC101344724	Protein ERGIC-53 isoform X2. (510 aa)
	LOC101357807	Serine/threonine-protein kinase N2 isoform X1. (981 aa)
	LOC101340712	Complement component 1 Q subcomponent-binding protein, mitochondrial. (178 aa)
	LOC101353760	Rho GTPase-activating protein 21 isoform X1. (1947 aa)
	LOC101353559	lamin-B receptor isoform X1. (499 aa)
	LOC101354827	Importin-11 isoform X1. (977 aa)
	LOC101349616	Erbin isoform X1. (1460 aa)
	LOC101354261	E3 ubiquitin-protein ligase RNFT1. (399 aa)
	LOC101351762	Rho guanine nucleotide exchange factor 10-like protein isoform X1. (1275 aa)
	LOC101349444	Tight junction protein ZO-2 isoform X1; Belongs to the MAGUK family. (1211 aa)
	LOC101357703	Transferrin receptor protein 1 isoform X1. (834 aa)
	LOC101344463	Formin-like protein 2 isoform X1. (1095 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340368	LOC101343223	A0A2Y9DI12	A0A2Y9QG20	Rho guanine nucleotide exchange factor 28.	Rho-associated protein kinase 1 isoform X1.	0.426
LOC101340368	LOC101345959	A0A2Y9DI12	A0A2Y9QPS9	Rho guanine nucleotide exchange factor 28.	Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.509
LOC101340368	LOC101350614	A0A2Y9DI12	A0A2Y9RUU5	Rho guanine nucleotide exchange factor 28.	Rho guanine nucleotide exchange factor 11.	0.418
LOC101340368	LOC101357892	A0A2Y9DI12	A0A2Y9DRQ7	Rho guanine nucleotide exchange factor 28.	Rho guanine nucleotide exchange factor 25 isoform X1.	0.418
LOC101340368	LOC101358090	A0A2Y9DI12	A0A2Y9RPR6	Rho guanine nucleotide exchange factor 28.	Rho guanine nucleotide exchange factor 12 isoform X1.	0.936
LOC101340368	LOC111819053	A0A2Y9DI12	A0A2Y9QMQ5	Rho guanine nucleotide exchange factor 28.	Rho-associated protein kinase 1-like.	0.426
LOC101340368	LOC111822717	A0A2Y9DI12	A0A2Y9S0G2	Rho guanine nucleotide exchange factor 28.	Rho-associated protein kinase 1.	0.426
LOC101340712	LOC101341682	A0A2Y9R5Q0	A0A2Y9E1F7	Complement component 1 Q subcomponent-binding protein, mitochondrial.	Anillin.	0.532
LOC101340712	LOC101341786	A0A2Y9R5Q0	A0A2Y9E7Q6	Complement component 1 Q subcomponent-binding protein, mitochondrial.	Ras GTPase-activating-like protein IQGAP3.	0.404
LOC101340712	LOC101345823	A0A2Y9R5Q0	A0A2Y9RT86	Complement component 1 Q subcomponent-binding protein, mitochondrial.	Vesicle-associated membrane protein 3.	0.477
LOC101340712	LOC101346791	A0A2Y9R5Q0	A0A2Y9D7B6	Complement component 1 Q subcomponent-binding protein, mitochondrial.	Rhotekin isoform X1.	0.508
LOC101340712	LOC101350331	A0A2Y9R5Q0	A0A2Y9RSD4	Complement component 1 Q subcomponent-binding protein, mitochondrial.	Unconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.600
LOC101340712	LOC101355667	A0A2Y9R5Q0	A0A2Y9G1P7	Complement component 1 Q subcomponent-binding protein, mitochondrial.	Junction plakoglobin.	0.423
LOC101340712	LOC101360937	A0A2Y9R5Q0	A0A2Y9DQE6	Complement component 1 Q subcomponent-binding protein, mitochondrial.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.513
LOC101340735	LOC101360492	A0A2Y9DUX7	A0A2Y9DL70	Rho GTPase-activating protein 35.	Rho GTPase-activating protein 5.	0.900
LOC101341495	LOC101341682	A0A2Y9DTR1	A0A2Y9E1F7	Vang-like protein.	Anillin.	0.505
LOC101341495	LOC101342810	A0A2Y9DTR1	A0A2Y9DAC7	Vang-like protein.	Disheveled-associated activator of morphogenesis 1.	0.528
LOC101341495	LOC101346061	A0A2Y9DTR1	A0A2Y9DRW4	Vang-like protein.	Disheveled-associated activator of morphogenesis 2 isoform X1.	0.528
LOC101341495	LOC101349444	A0A2Y9DTR1	A0A2Y9QT91	Vang-like protein.	Tight junction protein ZO-2 isoform X1; Belongs to the MAGUK family.	0.405
LOC101341495	LOC101349616	A0A2Y9DTR1	A0A2Y9R123	Vang-like protein.	Erbin isoform X1.	0.405