STRINGSTRING
LOC101342743 LOC101342743 LOC101342004 LOC101342004 LOC101349207 LOC101349207 LOC101345047 LOC101345047 LOC101357146 LOC101357146 LOC101342109 LOC101342109 LOC101346705 LOC101346705 LOC101356579 LOC101356579 LOC105755980 LOC105755980 LOC101345051 LOC101345051 LOC101348995 LOC101348995 LOC101356953 LOC101356953 LOC101345299 LOC101345299 LOC101340503 LOC101340503 IL1B IL1B LOC101361564 LOC101361564 LOC101342638 LOC101342638 LOC101347718 LOC101347718 LOC101351590 LOC101351590
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101342743Interleukin-10. (178 aa)
LOC101342004Nitric oxide synthase; Produces nitric oxide (NO). (1434 aa)
LOC101349207Peroxisome proliferator-activated receptor alpha. (468 aa)
LOC101345047Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
LOC101357146Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
LOC101342109Cathepsin L1; Belongs to the peptidase C1 family. (339 aa)
LOC101346705Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
LOC101356579Nitric oxide synthase; Produces nitric oxide (NO). (1161 aa)
LOC105755980Insulin. (156 aa)
LOC101345051Insulin receptor substrate 2. (1311 aa)
LOC101348995cAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
LOC101356953Nitric oxide synthase; Produces nitric oxide (NO). (1214 aa)
LOC101345299Cathepsin L1-like; Belongs to the peptidase C1 family. (334 aa)
LOC101340503LOW QUALITY PROTEIN: forkhead box protein O1. (656 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (262 aa)
LOC101361564Hormone-sensitive lipase. (771 aa)
LOC101342638cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)
LOC101347718Leptin receptor isoform X1. (1162 aa)
LOC101351590Interleukin-6. (237 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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