node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL1B | LOC101342743 | A0A2Y9RYF7 | A0A2Y9DIE0 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-10. | 0.844 |
IL1B | LOC101349207 | A0A2Y9RYF7 | A0A2Y9DS69 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Peroxisome proliferator-activated receptor alpha. | 0.422 |
IL1B | LOC101351590 | A0A2Y9RYF7 | A0A2Y9DMT4 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-6. | 0.861 |
IL1B | LOC101356579 | A0A2Y9RYF7 | A0A2Y9FZT2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Nitric oxide synthase; Produces nitric oxide (NO). | 0.523 |
IL1B | LOC101357146 | A0A2Y9RYF7 | A0A2Y9DY50 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.534 |
LOC101340503 | LOC101342638 | A0A2Y9RWM5 | A0A2Y9D7C8 | LOW QUALITY PROTEIN: forkhead box protein O1. | cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. | 0.926 |
LOC101340503 | LOC101345051 | A0A2Y9RWM5 | A0A2Y9G2Q0 | LOW QUALITY PROTEIN: forkhead box protein O1. | Insulin receptor substrate 2. | 0.423 |
LOC101340503 | LOC101346705 | A0A2Y9RWM5 | A0A2Y9EA78 | LOW QUALITY PROTEIN: forkhead box protein O1. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.421 |
LOC101340503 | LOC101348995 | A0A2Y9RWM5 | A0A2Y9QFS5 | LOW QUALITY PROTEIN: forkhead box protein O1. | cAMP-dependent protein kinase catalytic subunit alpha. | 0.926 |
LOC101340503 | LOC105755980 | A0A2Y9RWM5 | A0A2Y9G1D1 | LOW QUALITY PROTEIN: forkhead box protein O1. | Insulin. | 0.421 |
LOC101342004 | LOC101356579 | A0A2Y9DR73 | A0A2Y9FZT2 | Nitric oxide synthase; Produces nitric oxide (NO). | Nitric oxide synthase; Produces nitric oxide (NO). | 0.909 |
LOC101342004 | LOC101356953 | A0A2Y9DR73 | A0A2Y9QQH5 | Nitric oxide synthase; Produces nitric oxide (NO). | Nitric oxide synthase; Produces nitric oxide (NO). | 0.902 |
LOC101342109 | LOC101345047 | A0A2Y9E0X6 | A0A2Y9DUA6 | Cathepsin L1; Belongs to the peptidase C1 family. | Cathepsin L1; Belongs to the peptidase C1 family. | 0.900 |
LOC101342109 | LOC101345299 | A0A2Y9E0X6 | A0A2Y9RJ34 | Cathepsin L1; Belongs to the peptidase C1 family. | Cathepsin L1-like; Belongs to the peptidase C1 family. | 0.900 |
LOC101342638 | LOC101340503 | A0A2Y9D7C8 | A0A2Y9RWM5 | cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. | LOW QUALITY PROTEIN: forkhead box protein O1. | 0.926 |
LOC101342638 | LOC101348995 | A0A2Y9D7C8 | A0A2Y9QFS5 | cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. | cAMP-dependent protein kinase catalytic subunit alpha. | 0.900 |
LOC101342638 | LOC101349207 | A0A2Y9D7C8 | A0A2Y9DS69 | cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. | Peroxisome proliferator-activated receptor alpha. | 0.908 |
LOC101342638 | LOC101361564 | A0A2Y9D7C8 | A0A2Y9S2B3 | cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. | Hormone-sensitive lipase. | 0.950 |
LOC101342743 | IL1B | A0A2Y9DIE0 | A0A2Y9RYF7 | Interleukin-10. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.844 |
LOC101342743 | LOC101347718 | A0A2Y9DIE0 | A0A2Y9D7C9 | Interleukin-10. | Leptin receptor isoform X1. | 0.699 |