STRINGSTRING
LOC101347626 LOC101347626 LOC101341781 LOC101341781 LOC101351897 LOC101351897 LOC101356840 LOC101356840 LOC101344992 LOC101344992 LOC101345414 LOC101345414 LOC101361653 LOC101361653 LOC101342638 LOC101342638 LOC101349498 LOC101349498 LOC101345935 LOC101345935 LOC101352077 LOC101352077 LOC101352844 LOC101352844 LOC101342296 LOC101342296 LOC101351819 LOC101351819 LOC101342810 LOC101342810 LOC101343746 LOC101343746 LOC101348322 LOC101348322 LOC101352434 LOC101352434 LOC101349005 LOC101349005 LOC101341459 LOC101341459 LOC101360991 LOC101360991 LOC101355330 LOC101355330 LOC101345956 LOC101345956 LOC101353039 LOC101353039 LOC101354243 LOC101354243 LOC101344282 LOC101344282 LOC101356454 LOC101356454 LOC101349186 LOC101349186 LOC101341897 LOC101341897 LOC101359009 LOC101359009 LOC101355428 LOC101355428 LOC101349359 LOC101349359 LOC101348250 LOC101348250 LOC101347495 LOC101347495 LOC101342156 LOC101342156 LOC101354576 LOC101354576 LOC101360313 LOC101360313 LOC101349614 LOC101349614 LOC101347661 LOC101347661 LOC101341899 LOC101341899 LOC101340702 LOC101340702 LOC101344857 LOC101344857 LOC101340816 LOC101340816 LOC101347671 LOC101347671 LOC101360142 LOC101360142 LOC101341737 LOC101341737 LOC101342083 LOC101342083 LOC101349448 LOC101349448 LOC101360934 LOC101360934 LOC101358150 LOC101358150 LOC101347003 LOC101347003 LOC101346660 LOC101346660 LOC101350207 LOC101350207 LOC101351688 LOC101351688 LOC101342596 LOC101342596 LOC101346061 LOC101346061 LOC101343707 LOC101343707 LOC101354435 LOC101354435 LOC101358065 LOC101358065 LOC101348949 LOC101348949 LOC101360249 LOC101360249 LOC101342766 LOC101342766 LOC101341495 LOC101341495 LOC101351340 LOC101351340 LOC101351510 LOC101351510 LOC101359902 LOC101359902 LOC101344881 LOC101344881 LOC101342423 LOC101342423 LOC101351429 LOC101351429 LOC101343886 LOC101343886 LOC101360163 LOC101360163 LOC101362049 LOC101362049 LOC101351254 LOC101351254 LOC101340313 LOC101340313 LOC101357820 LOC101357820 LOC101352296 LOC101352296 LOC101359745 LOC101359745 LOC101355288 LOC101355288 LOC101345396 LOC101345396 LOC101360002 LOC101360002 LOC101359224 LOC101359224 LOC101350591 LOC101350591 LOC101360353 LOC101360353 LOC101349728 LOC101349728 LOC101359840 LOC101359840 LOC101341353 LOC101341353 LOC101346853 LOC101346853 LOC101353435 LOC101353435 LOC101340585 LOC101340585 LOC101340490 LOC101340490 LOC101342624 LOC101342624 LOC101354037 LOC101354037 LOC101359317 LOC101359317 LOC101353082 LOC101353082 LOC101358700 LOC101358700 LOC101361647 LOC101361647 LOC101349745 LOC101349745 LOC101352160 LOC101352160 LOC101351717 LOC101351717 LOC101341696 LOC101341696 LOC101346094 LOC101346094 LOC101344186 LOC101344186 LOC101346360 LOC101346360 LOC101348994 LOC101348994 LOC101351734 LOC101351734 LOC101360550 LOC101360550 LOC101350695 LOC101350695 LOC101345345 LOC101345345 LOC101361339 LOC101361339 LOC101344726 LOC101344726 LOC101353424 LOC101353424 LOC101357577 LOC101357577 LOC101343360 LOC101343360 LOC101353113 LOC101353113 LOC101358885 LOC101358885 LOC101359059 LOC101359059 LOC101343546 LOC101343546 LOC101356576 LOC101356576 LOC101342462 LOC101342462 LOC101347137 LOC101347137 LOC101348995 LOC101348995 LOC101352430 LOC101352430 LOC101350263 LOC101350263 LOC101354147 LOC101354147 LOC101359173 LOC101359173 LOC101345959 LOC101345959 LOC101346985 LOC101346985 LOC101361763 LOC101361763 LOC101351306 LOC101351306 LOC101341158 LOC101341158 LOC101361433 LOC101361433 LOC101349786 LOC101349786 LOC101345532 LOC101345532 LOC101351852 LOC101351852 LOC101362025 LOC101362025 LOC101356054 LOC101356054 LOC101345125 LOC101345125 LOC101343394 LOC101343394 LOC101349967 LOC101349967 LOC101361961 LOC101361961 LOC101358763 LOC101358763 LOC101342024 LOC101342024 LOC101357894 LOC101357894 LOC101344242 LOC101344242 LOC101347440 LOC101347440 LOC101355118 LOC101355118 LOC101347784 LOC101347784 LOC101353682 LOC101353682 LOC101350837 LOC101350837 LOC101349983 LOC101349983 LOC101361375 LOC101361375 LOC101352330 LOC101352330 LOC101354216 LOC101354216 LOC101355751 LOC101355751
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101347626RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
LOC101341781Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LOC101351897Catenin beta-1. (781 aa)
LOC101356840Transforming protein RhoA. (193 aa)
LOC101344992Prickle-like protein 2. (842 aa)
LOC101345414Inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (936 aa)
LOC101361653Transcription factor AP-1; Belongs to the bZIP family. (329 aa)
LOC101342638cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)
LOC101349498Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (948 aa)
LOC101345935F-box/WD repeat-containing protein 1A isoform X1. (605 aa)
LOC101352077Proto-oncogene FRAT1. (268 aa)
LOC101352844Secreted frizzled-related protein 5. (302 aa)
LOC101342296Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
LOC101351819Dickkopf-related protein 1. (268 aa)
LOC101342810Disheveled-associated activator of morphogenesis 1. (1069 aa)
LOC101343746R-spondin-2 isoform X1. (243 aa)
LOC101348322Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (719 aa)
LOC101352434Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1074 aa)
LOC101349005Casein kinase II subunit alpha' isoform X1; Belongs to the protein kinase superfamily. (350 aa)
LOC101341459Protein naked cuticle homolog 1. (470 aa)
LOC101360991R-spondin-1. (263 aa)
LOC101355330Calcineurin subunit B type 2. (170 aa)
LOC101345956Calcyclin-binding protein. (230 aa)
LOC101353039WNT1-inducible-signaling pathway protein 1 isoform X1. (367 aa)
LOC101354243Transcription factor SOX-17. (408 aa)
LOC101344282CREB-binding protein. (2447 aa)
LOC101356454Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LOC101349186Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC101341897Protein chibby homolog 1. (127 aa)
LOC101359009Cerberus. (273 aa)
LOC101355428Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
LOC101349359E3 ubiquitin-protein ligase RBX1 isoform X1. (108 aa)
LOC101348250Protein kinase C alpha type isoform X2. (549 aa)
LOC101347495Axin-2. (839 aa)
LOC101342156Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
LOC101354576Sclerostin. (213 aa)
LOC101360313Ras-related C3 botulinum toxin substrate 3. (188 aa)
LOC101349614Histone acetyltransferase p300. (2422 aa)
LOC101347661Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (566 aa)
LOC101341899Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LOC101340702C-terminal-binding protein 2 isoform X1. (989 aa)
LOC101344857Mothers against decapentaplegic homolog. (425 aa)
LOC101340816Leucine-rich repeat-containing G-protein coupled receptor 6. (985 aa)
LOC101347671Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
LOC101360142Segment polarity protein dishevelled homolog DVL-2. (736 aa)
LOC101341737Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (448 aa)
LOC101342083Prickle planar cell polarity protein 3 isoform X1. (606 aa)
LOC101349448Protein-serine O-palmitoleoyltransferase porcupine isoform X1; Belongs to the membrane-bound acyltransferase family. (461 aa)
LOC101360934E3 ubiquitin-protein ligase RNF43 isoform X1. (783 aa)
LOC101358150Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
LOC101347003Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LOC101346660Adenomatous polyposis coli protein 2. (1344 aa)
LOC101350207Prickle-like protein 4. (421 aa)
LOC101351688G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
LOC101342596Secreted frizzled-related protein 2. (295 aa)
LOC101346061Disheveled-associated activator of morphogenesis 2 isoform X1. (1067 aa)
LOC101343707Dickkopf-related protein 2. (259 aa)
LOC101354435CXXC-type zinc finger protein 4. (299 aa)
LOC101358065Glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
LOC101348949Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LOC101360249Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (544 aa)
LOC101342766Catenin delta-2 isoform X1. (887 aa)
LOC101341495Vang-like protein. (524 aa)
LOC101351340Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
LOC101351510G1/S-specific cyclin-D2 isoform X1; Belongs to the cyclin family. (289 aa)
LOC101359902Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
LOC101344881Wnt inhibitory factor 1. (379 aa)
LOC101342423Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LOC101351429Tyrosine-protein kinase RYK. (475 aa)
LOC101343886Dickkopf-related protein 4. (220 aa)
LOC101360163Cullin-1; Belongs to the cullin family. (776 aa)
LOC101362049Segment polarity protein dishevelled homolog DVL-3. (716 aa)
LOC101351254Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC101340313Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LOC101357820Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
LOC1013522961-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC101359745G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LOC101355288Low-density lipoprotein receptor-related protein 5. (1719 aa)
LOC101345396Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LOC101360002Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (461 aa)
LOC101359224Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (486 aa)
LOC101350591S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC101360353Beta-catenin-interacting protein 1. (81 aa)
LOC101349728F-box-like/WD repeat-containing protein TBL1X. (529 aa)
LOC101359840Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
LOC101341353Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (365 aa)
LOC101346853Matrilysin. (267 aa)
LOC101353435Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1; Belongs to the protein kinase superfamily. (499 aa)
LOC101340585Secreted frizzled-related protein 4. (353 aa)
LOC101340490Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
LOC101342624BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LOC101354037Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1. (904 aa)
LOC101359317Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
LOC101353082Calcium/calmodulin-dependent protein kinase type II subunit beta. (655 aa)
LOC101358700Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
LOC101361647Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (472 aa)
LOC101349745Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (909 aa)
LOC101352160Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LOC101351717Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC101341696Transcription factor 7-like 1. (463 aa)
LOC101346094Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC101344186Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
LOC101346360R-spondin-3. (275 aa)
LOC101348994Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (650 aa)
LOC101351734Mitogen-activated protein kinase. (464 aa)
LOC101360550Peroxisome proliferator-activated receptor delta. (441 aa)
LOC101350695Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (900 aa)
LOC101345345Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
LOC101361339Palmitoleoyl-protein carboxylesterase NOTUM. (406 aa)
LOC101344726Protein naked cuticle homolog 2. (470 aa)
LOC101353424Serine/threonine-protein phosphatase. (525 aa)
LOC101357577Fos-related antigen 1 isoform X1. (274 aa)
LOC101343360Secreted frizzled-related protein 1. (229 aa)
LOC101353113Vang-like protein. (522 aa)
LOC101358885Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LOC101359059Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (933 aa)
LOC101343546Mitogen-activated protein kinase. (427 aa)
LOC101356576Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
LOC101342462R-spondin-4. (170 aa)
LOC101347137Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (469 aa)
LOC101348995cAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
LOC101352430Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2590 aa)
LOC101350263Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (391 aa)
LOC101354147F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
LOC101359173Inversin isoform X1. (1079 aa)
LOC101345959Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1405 aa)
LOC101346985Axin-1 isoform X1. (878 aa)
LOC101361763Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (458 aa)
LOC101351306E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (331 aa)
LOC101341158Adenomatous polyposis coli protein isoform X1. (2856 aa)
LOC101361433Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
LOC101349786Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
LOC101345532Transcription factor 7-like 2 isoform X1. (381 aa)
LOC101351852Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
LOC101362025Pigment epithelium-derived factor; Belongs to the serpin family. (418 aa)
LOC101356054Ras-related C3 botulinum toxin substrate 1. (148 aa)
LOC101345125Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
LOC101343394Calcineurin subunit B type 1 isoform X1. (170 aa)
LOC101349967Phosphoinositide phospholipase C. (909 aa)
LOC101361961Calcium/calmodulin-dependent protein kinase type II subunit gamma. (821 aa)
LOC101358763Mothers against decapentaplegic homolog. (552 aa)
LOC101342024C-terminal-binding protein 1. (485 aa)
LOC101357894Serine/threonine-protein phosphatase. (511 aa)
LOC1013442421-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
LOC101347440Serine/threonine-protein phosphatase. (418 aa)
LOC101355118Sentrin-specific protease 2 isoform X1. (588 aa)
LOC101347784F-box-like/WD repeat-containing protein TBL1XR1 isoform X1. (514 aa)
LOC101353682Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
LOC101350837LOW QUALITY PROTEIN: transcription factor 7. (493 aa)
LOC101349983Prickle-like protein 1. (832 aa)
LOC1013613751-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
LOC101352330GSK-3-binding protein FRAT2. (235 aa)
LOC101354216E3 ubiquitin-protein ligase ZNRF3 isoform X1. (842 aa)
LOC101355751Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (930 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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