46 items (Trichechus manatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101342638	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)
	LOC101345935	F-box/WD repeat-containing protein 1A isoform X1. (605 aa)
	LOC101354554	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
	LOC101349254	Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1337 aa)
	LOC101354158	Protein patched homolog 2. (1206 aa)
	LOC101351744	LOW QUALITY PROTEIN: sonic hedgehog protein. (272 aa)
	LOC101351217	Uncharacterized protein C16orf52 homolog. (167 aa)
	LOC101350880	Brother of CDO. (1121 aa)
	LOC101349186	Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
	LOC101351406	E3 ubiquitin-protein ligase. (748 aa)
	LOC101348175	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	LOC101359624	Cullin-3 isoform X1; Belongs to the cullin family. (768 aa)
	LOC101358403	Speckle-type POZ protein. (374 aa)
	LOC101343608	Casein kinase I; Belongs to the protein kinase superfamily. (349 aa)
	LOC101354516	Hedgehog-interacting protein. (700 aa)
	LOC101344305	Cell adhesion molecule-related/down-regulated by oncogenes. (1263 aa)
	LOC101347007	Apoptosis regulator Bcl-2 isoform X1. (229 aa)
	LOC101351510	G1/S-specific cyclin-D2 isoform X1; Belongs to the cyclin family. (289 aa)
	LOC101346502	Protein patched homolog 1 isoform X1. (1453 aa)
	LOC101360163	Cullin-1; Belongs to the cullin family. (776 aa)
	LOC101358165	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (749 aa)
	LOC101359745	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	LOC101343801	Ellis-van Creveld syndrome protein. (998 aa)
	LOC101356905	G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (529 aa)
	LOC101355035	Transcriptional activator GLI3. (1586 aa)
	LOC101341353	Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (365 aa)
	LOC101342888	LOW QUALITY PROTEIN: zinc finger protein GLI2. (1469 aa)
	LOC101353606	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	LOC101357163	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
	LOC101347831	E3 ubiquitin-protein ligase MGRN1. (575 aa)
	LOC101342744	Low-density lipoprotein receptor-related protein 2. (4634 aa)
	LOC101348995	cAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
	LOC101354147	F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
	LOC101361763	Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (458 aa)
	LOC101359184	Casein kinase I; Belongs to the protein kinase superfamily. (459 aa)
	LOC101350046	Speckle-type POZ protein-like isoform X1. (392 aa)
	LOC101341907	Beta-arrestin-2 isoform X1. (452 aa)
	LOC101359274	Casein kinase I. (280 aa)
	LOC101361695	Zinc finger protein GLI1. (1100 aa)
	LOC101344058	Limbin. (1209 aa)
	LOC101354945	Beta-arrestin-1. (395 aa)
	LOC101358954	Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (456 aa)
	LOC101346329	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (686 aa)
	LOC101351951	Growth arrest-specific protein 1. (363 aa)
	LOC101355217	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (699 aa)
	LOC101361308	Multiple epidermal growth factor-like domains protein 8. (2591 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101341353	LOC101342638	A0A2Y9E2I9	A0A2Y9D7C8	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.924
LOC101341353	LOC101342888	A0A2Y9E2I9	A0A2Y9E6J3	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	LOW QUALITY PROTEIN: zinc finger protein GLI2.	0.562
LOC101341353	LOC101345935	A0A2Y9E2I9	A0A2Y9D8R6	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	F-box/WD repeat-containing protein 1A isoform X1.	0.562
LOC101341353	LOC101346329	A0A2Y9E2I9	A0A2Y9RHM8	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.949
LOC101341353	LOC101348995	A0A2Y9E2I9	A0A2Y9QFS5	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha.	0.924
LOC101341353	LOC101349186	A0A2Y9E2I9	A0A2Y9DFM9	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily.	0.979
LOC101341353	LOC101354147	A0A2Y9E2I9	A0A2Y9QLE1	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	F-box/WD repeat-containing protein 11 isoform X1.	0.575
LOC101341353	LOC101354554	A0A2Y9E2I9	A0A2Y9D8U4	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.742
LOC101341353	LOC101355035	A0A2Y9E2I9	A0A2Y9E0N1	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Transcriptional activator GLI3.	0.670
LOC101341353	LOC101357163	A0A2Y9E2I9	A0A2Y9E7G1	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.949
LOC101341353	LOC101358165	A0A2Y9E2I9	A0A2Y9DX18	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.971
LOC101341353	LOC101359274	A0A2Y9E2I9	A0A2Y9QZV2	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Casein kinase I.	0.558
LOC101341353	LOC101359624	A0A2Y9E2I9	A0A2Y9DKY0	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Cullin-3 isoform X1; Belongs to the cullin family.	0.558
LOC101341353	LOC101360163	A0A2Y9E2I9	A0A2Y9DW63	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Cullin-1; Belongs to the cullin family.	0.710
LOC101341353	LOC101361695	A0A2Y9E2I9	A0A2Y9RA27	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Zinc finger protein GLI1.	0.564
LOC101341353	LOC101361763	A0A2Y9E2I9	A0A2Y9QRZ9	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	Casein kinase I isoform X1; Belongs to the protein kinase superfamily.	0.562
LOC101341907	LOC101342888	A0A2Y9QXT5	A0A2Y9E6J3	Beta-arrestin-2 isoform X1.	LOW QUALITY PROTEIN: zinc finger protein GLI2.	0.907
LOC101341907	LOC101346329	A0A2Y9QXT5	A0A2Y9RHM8	Beta-arrestin-2 isoform X1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.876
LOC101341907	LOC101354945	A0A2Y9QXT5	A0A2Y9RFJ7	Beta-arrestin-2 isoform X1.	Beta-arrestin-1.	0.901
LOC101341907	LOC101355035	A0A2Y9QXT5	A0A2Y9E0N1	Beta-arrestin-2 isoform X1.	Transcriptional activator GLI3.	0.904