STRINGSTRING
LOC101357840 LOC101357840 LOC101342128 LOC101342128 LOC101341952 LOC101341952 LOC101354381 LOC101354381 LOC101345326 LOC101345326 LOC101360368 LOC101360368 LOC101342638 LOC101342638 LOC101355565 LOC101355565 LOC101356345 LOC101356345 LOC101349247 LOC101349247 LOC101347051 LOC101347051 LOC101349504 LOC101349504 LOC101341708 LOC101341708 LOC101345850 LOC101345850 LOC101359953 LOC101359953 LOC101353895 LOC101353895 LOC101357541 LOC101357541 LOC101350704 LOC101350704 LOC101344705 LOC101344705 LOC101351136 LOC101351136 LOC101348417 LOC101348417 LOC101359616 LOC101359616 LOC101349439 LOC101349439 LOC101343332 LOC101343332 LOC101340445 LOC101340445 LOC101344857 LOC101344857 LOC101359453 LOC101359453 LOC101341480 LOC101341480 LOC101342248 LOC101342248 LOC101343253 LOC101343253 LOC101360493 LOC101360493 LOC101349290 LOC101349290 LOC101354510 LOC101354510 LOC101341078 LOC101341078 LOC101351770 LOC101351770 LOC101342004 LOC101342004 LOC101346145 LOC101346145 LOC101344230 LOC101344230 LOC101347686 LOC101347686 LOC101360334 LOC101360334 LOC101357647 LOC101357647 LOC101349553 LOC101349553 LOC101360593 LOC101360593 LOC101343271 LOC101343271 LOC101345725 LOC101345725 LOC101348280 LOC101348280 LOC101350991 LOC101350991 LOC101352296 LOC101352296 LOC101354200 LOC101354200 LOC101343535 LOC101343535 LOC101359745 LOC101359745 LOC101342107 LOC101342107 LOC101355469 LOC101355469 LOC101347525 LOC101347525 LOC101355634 LOC101355634 LOC101356907 LOC101356907 LOC101343808 LOC101343808 LOC101358955 LOC101358955 LOC101342872 LOC101342872 LOC101354868 LOC101354868 LOC101342034 LOC101342034 LOC101346525 LOC101346525 LOC101340589 LOC101340589 LOC101341777 LOC101341777 LOC101355136 LOC101355136 LOC101345319 LOC101345319 LOC101348466 LOC101348466 LOC101347875 LOC101347875 LOC101349243 LOC101349243 LOC101352672 LOC101352672 LOC101346092 LOC101346092 LOC101353011 LOC101353011 LOC101342042 LOC101342042 LOC101356927 LOC101356927 LOC101354392 LOC101354392 LOC101350438 LOC101350438 LOC101348656 LOC101348656 LOC101358487 LOC101358487 LOC101358846 LOC101358846 LOC101356099 LOC101356099 LOC101361121 LOC101361121 LOC101349952 LOC101349952 LOC101341327 LOC101341327 LOC101356579 LOC101356579 LOC101359111 LOC101359111 LOC101343228 LOC101343228 LOC101346784 LOC101346784 LOC111819060 LOC111819060 LOC101348995 LOC101348995 LOC101350182 LOC101350182 LOC101352593 LOC101352593 LOC101349182 LOC101349182 LOC101346209 LOC101346209 LOC101342804 LOC101342804 LOC101340959 LOC101340959 LOC111819711 LOC111819711 LOC101359690 LOC101359690 LOC101346473 LOC101346473 LOC101356953 LOC101356953 LOC101341715 LOC101341715 LOC101343689 LOC101343689 LOC101350197 LOC101350197 LOC101346475 LOC101346475 LOC101351188 LOC101351188 LOC101346041 LOC101346041 LOC101352786 LOC101352786 LOC101352004 LOC101352004 LOC101360148 LOC101360148 LOC101347845 LOC101347845 LOC101345298 LOC101345298 LOC111821467 LOC111821467 LOC101356476 LOC101356476 LOC101346534 LOC101346534 LOC101349967 LOC101349967 LOC101361359 LOC101361359 LOC101354889 LOC101354889 LOC101358763 LOC101358763 LOC101344242 LOC101344242 LOC101347126 LOC101347126 LOC101354532 LOC101354532 LOC101350742 LOC101350742 LOC101341926 LOC101341926 LOC101357482 LOC101357482 LOC101357176 LOC101357176 LOC101348371 LOC101348371 LOC101361375 LOC101361375 LOC101347192 LOC101347192 LOC101356404 LOC101356404 LOC101358526 LOC101358526 LOC101351543 LOC101351543 LOC101346948 LOC101346948 LOC101361564 LOC101361564
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101357840RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC101342128Myosin light chain 3. (201 aa)
LOC101341952Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (355 aa)
LOC101354381Connective tissue growth factor. (349 aa)
LOC101345326Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC101360368Non-specific serine/threonine protein kinase. (552 aa)
LOC101342638cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)
LOC101355565Phosphodiesterase. (1130 aa)
LOC101356345Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
LOC101349247Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC101347051Transcription factor A, mitochondrial isoform X1. (246 aa)
LOC101349504Perilipin; Belongs to the perilipin family. (519 aa)
LOC101341708Sodium/calcium exchanger 3 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
LOC101345850Myosin light chain kinase 2, skeletal/cardiac muscle. (606 aa)
LOC101359953Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
LOC101353895Myocyte-specific enhancer factor 2A isoform X1. (495 aa)
LOC101357541Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC101350704Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
LOC101344705Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
LOC101351136Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
LOC10134841740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
LOC101359616Myosin light chain 4. (224 aa)
LOC101349439Sphingosine kinase 1. (471 aa)
LOC101343332Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC101340445Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
LOC101344857Mothers against decapentaplegic homolog. (425 aa)
LOC101359453Gamma-aminobutyric acid receptor-associated protein. (117 aa)
LOC1013414805'-AMP-activated protein kinase subunit gamma-3. (500 aa)
LOC101342248Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
LOC101343253Calcium/calmodulin-dependent protein kinase type IV isoform X3; Belongs to the protein kinase superfamily. (472 aa)
LOC101360493Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC101349290Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
LOC101354510Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
LOC101341078Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC101351770Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (147 aa)
LOC101342004Nitric oxide synthase; Produces nitric oxide (NO). (1434 aa)
LOC101346145Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC101344230GTPase NRas isoform X1. (189 aa)
LOC101347686Ryanodine receptor 3. (4875 aa)
LOC101360334Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (977 aa)
LOC101357647Ras-related protein M-Ras isoform X1. (208 aa)
LOC101349553Ras-related protein R-Ras. (218 aa)
LOC101360593Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (540 aa)
LOC101343271Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
LOC101345725Phosphoinositide 3-kinase regulatory subunit 4 isoform X1. (1358 aa)
LOC101348280Guanine nucleotide-binding protein subunit beta-4. (340 aa)
LOC101350991Plasminogen activator; Belongs to the peptidase S1 family. (563 aa)
LOC1013522961-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC101354200Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LOC101343535Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LOC101359745G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LOC101342107Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC101355469Adenylate cyclase type 10 isoform X1. (1609 aa)
LOC101347525GTPase KRas isoform X3. (227 aa)
LOC101355634Krueppel-like factor 2. (195 aa)
LOC101356907Myocyte-specific enhancer factor 2B. (368 aa)
LOC101343808Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
LOC101358955Neurogenic locus notch homolog protein 3. (2329 aa)
LOC101342872LOW QUALITY PROTEIN: mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
LOC101354868Adenylate cyclase type 1. (903 aa)
LOC101342034Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
LOC101346525Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
LOC101340589Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
LOC101341777Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LOC101355136Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
LOC101345319Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
LOC101348466Plasminogen activator inhibitor 1; Belongs to the serpin family. (400 aa)
LOC101347875Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
LOC101349243Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
LOC1013526725'-AMP-activated protein kinase subunit gamma-1 isoform X1. (331 aa)
LOC101346092Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC101353011Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (389 aa)
LOC101342042Myocyte-specific enhancer factor 2D isoform X1. (518 aa)
LOC101356927Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
LOC101354392Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
LOC101350438Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1076 aa)
LOC101348656Mothers against decapentaplegic homolog. (467 aa)
LOC101358487Calmodulin; Belongs to the calmodulin family. (113 aa)
LOC101358846LOW QUALITY PROTEIN: calmodulin-like protein 3; Belongs to the calmodulin family. (148 aa)
LOC101356099Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC101361121LOW QUALITY PROTEIN: calmodulin-like protein 6. (188 aa)
LOC101349952LOW QUALITY PROTEIN: beclin-2. (363 aa)
LOC101341327Guanine nucleotide-binding protein subunit beta-5. (353 aa)
LOC101356579Nitric oxide synthase; Produces nitric oxide (NO). (1161 aa)
LOC101359111Calmodulin-like. (149 aa)
LOC101343228Osteopontin. (304 aa)
LOC101346784Non-specific serine/threonine protein kinase. (565 aa)
LOC111819060Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC101348995cAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
LOC101350182Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (884 aa)
LOC101352593Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (119 aa)
LOC1013491825'-AMP-activated protein kinase subunit gamma-2 isoform X1. (574 aa)
LOC101346209Ryanodine receptor 2. (5041 aa)
LOC101342804GTPase HRas isoform X1. (189 aa)
LOC101340959Myosin light chain kinase, smooth muscle isoform X1. (1961 aa)
LOC111819711Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC101359690Beclin-1 isoform X1. (448 aa)
LOC101346473Calmodulin-like protein 4. (153 aa)
LOC101356953Nitric oxide synthase; Produces nitric oxide (NO). (1214 aa)
LOC101341715Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
LOC101343689Phosphoinositide 3-kinase regulatory subunit 5. (875 aa)
LOC101350197Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (393 aa)
LOC101346475Myocyte-specific enhancer factor 2C isoform X1. (483 aa)
LOC101351188Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC101346041Adenylate cyclase type 5. (1265 aa)
LOC101352786Phosphoinositide 3-kinase regulatory subunit 6. (422 aa)
LOC101352004Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1120 aa)
LOC101360148Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
LOC101347845Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1. (112 aa)
LOC101345298Phosphatidylinositol 3-kinase catalytic subunit type 3. (914 aa)
LOC111821467Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
LOC1013564765'-AMP-activated protein kinase subunit beta-2 isoform X1. (282 aa)
LOC101346534Inositol 1,4,5-trisphosphate receptor type 1. (2715 aa)
LOC101349967Phosphoinositide phospholipase C. (909 aa)
LOC1013613595'-AMP-activated protein kinase subunit beta-1 isoform X1. (271 aa)
LOC101354889Ras-related protein R-Ras2. (169 aa)
LOC101358763Mothers against decapentaplegic homolog. (552 aa)
LOC1013442421-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
LOC101347126Calmodulin-2 isoform X1; Belongs to the calmodulin family. (153 aa)
LOC101354532Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
LOC101350742Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
LOC101341926Sodium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (923 aa)
LOC101357482Sphingosine kinase 2. (651 aa)
LOC101357176Actin, aortic smooth muscle. (377 aa)
LOC101348371Nuclear respiratory factor 1 isoform X1. (503 aa)
LOC1013613751-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
LOC101347192Guanine nucleotide-binding protein G(Q) subunit alpha isoform X3. (381 aa)
LOC101356404Inositol 1,4,5-trisphosphate receptor type 2. (2441 aa)
LOC101358526Mitogen-activated protein kinase 1. (263 aa)
LOC101351543Ryanodine receptor 1. (4842 aa)
LOC101346948Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1046 aa)
LOC101361564Hormone-sensitive lipase. (771 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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