108 items (Trichechus manatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101351897	Catenin beta-1. (781 aa)
	LOC101356840	Transforming protein RhoA. (193 aa)
	LOC101341952	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (355 aa)
	LOC101345929	Ezrin. (586 aa)
	LOC101347717	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	LOC101346277	Myosin regulatory light polypeptide 9. (172 aa)
	LOC101347888	Matrix metalloproteinase-9. (724 aa)
	LOC101359687	Alpha-actinin-1 isoform X3. (914 aa)
	LOC101351035	Phosphatidylinositol 3-kinase regulatory subunit gamma. (462 aa)
	LOC101358817	72 kDa type IV collagenase. (659 aa)
	LOC101347064	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
	LOC101349513	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
	LOC101356954	Neutrophil cytosol factor 2. (520 aa)
	LOC101356454	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	LOC101361504	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
	LOC101361759	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
	LOC101355428	Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
	LOC101348250	Protein kinase C alpha type isoform X2. (549 aa)
	LOC101347746	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	LOC101344372	Actin, cytoplasmic 2. (375 aa)
	LOC101349103	C-X-C chemokine receptor type 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	LOC101351755	Integrin alpha-4; Belongs to the integrin alpha chain family. (1032 aa)
	LOC101341572	Rap guanine nucleotide exchange factor 4. (1008 aa)
	LOC101344376	Ras association domain-containing protein 5 isoform X1. (416 aa)
	LOC101358927	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	LOC101360492	Rho GTPase-activating protein 5. (1503 aa)
	LOC101344219	Cytochrome b-245 heavy chain isoform X1. (570 aa)
	LOC101361943	Cell division control protein 42 homolog isoform X1. (191 aa)
	LOC101346393	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
	LOC101355438	Cytochrome b-245 light chain isoform X1. (196 aa)
	LOC101351770	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (147 aa)
	LOC101361614	Mitogen-activated protein kinase. (283 aa)
	LOC101353246	Junctional adhesion molecule C. (328 aa)
	LOC101346063	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
	LOC101361872	Mitogen-activated protein kinase. (366 aa)
	LOC101348869	Endothelial cell-selective adhesion molecule. (393 aa)
	LOC101352466	Mitogen-activated protein kinase. (595 aa)
	LOC101340309	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	LOC101343104	Neutrophil cytosol factor 1 isoform X1. (391 aa)
	LOC101356055	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
	LOC101340566	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	LOC101340735	Rho GTPase-activating protein 35. (1501 aa)
	LOC101359381	Moesin. (577 aa)
	LOC101343271	Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
	LOC101348780	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (307 aa)
	LOC101351254	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	LOC101354947	Protein-tyrosine kinase 2-beta isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	LOC101349039	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	LOC101350153	Vinculin isoform X4. (1134 aa)
	LOC101341174	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (288 aa)
	LOC101355465	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
	LOC101346849	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101343804	Phosphatidylinositol 3-kinase regulatory subunit beta. (729 aa)
	LOC101345146	Vascular cell adhesion protein 1 isoform X1. (739 aa)
	LOC101349050	Integrin beta. (773 aa)
	LOC101341015	Thy-1 membrane glycoprotein. (161 aa)
	LOC101348970	Myosin regulatory light chain 10. (147 aa)
	LOC101343640	Catenin alpha-3. (895 aa)
	LOC101342536	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
	LOC101346602	Myosin regulatory light chain 2, atrial isoform. (148 aa)
	LOC101355641	Integrin alpha-L; Belongs to the integrin alpha chain family. (1170 aa)
	LOC101348975	Myosin regulatory light chain 2, skeletal muscle isoform. (169 aa)
	LOC101346861	Breast cancer anti-estrogen resistance protein 1. (840 aa)
	LOC101343550	Guanine nucleotide exchange factor VAV2. (839 aa)
	LOC101346092	Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
	LOC101349753	Myosin regulatory light polypeptide 9. (172 aa)
	LOC101360113	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
	LOC101357857	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	LOC101346027	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (406 aa)
	LOC101348240	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
	LOC101347066	Stromal cell-derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	LOC101357691	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
	LOC101342831	Neutrophil cytosol factor 4. (349 aa)
	LOC101352970	LOW QUALITY PROTEIN: putative claudin-25. (246 aa)
	LOC101344659	Rap guanine nucleotide exchange factor 3. (923 aa)
	LOC101348129	Ras-related protein Rap-1b. (184 aa)
	LOC101356848	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
	LOC101359597	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	LOC101359611	CD99 antigen-like protein 2. (257 aa)
	LOC101361049	Afadin. (1851 aa)
	LOC101358905	Junctional adhesion molecule A. (298 aa)
	LOC101345959	Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1405 aa)
	LOC101347980	Tyrosine-protein kinase. (681 aa)
	LOC101340441	Platelet endothelial cell adhesion molecule isoform X1. (796 aa)
	LOC101358649	Junctional adhesion molecule B. (460 aa)
	LOC101344856	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
	LOC101348102	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	LOC101347509	Proto-oncogene vav. (841 aa)
	LOC101343257	Intercellular adhesion molecule 1. (345 aa)
	LOC101356054	Ras-related C3 botulinum toxin substrate 1. (148 aa)
	LOC101347350	Mitogen-activated protein kinase. (321 aa)
	LOC101341927	Vasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (381 aa)
	LOC101361370	Catenin alpha-1 isoform X1. (925 aa)
	LOC101358678	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1082 aa)
	LOC101352801	Ras-related protein Rap-1A. (184 aa)
	LOC101359658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	LOC111822151	CD99 antigen isoform X1. (178 aa)
	LOC111822157	Glycoprotein Xg. (180 aa)
	LOC101354697	Tyrosine-protein kinase. (529 aa)
	LOC101343534	Myosin light chain 5. (264 aa)
	LOC101361962	LOW QUALITY PROTEIN: signal-induced proliferation-associated protein 1. (1025 aa)
	LOC101357920	Integrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1153 aa)
	LOC101351714	Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
	LOC101354363	Rho-related GTP-binding protein RhoH. (191 aa)
	LOC101351810	Alpha-actinin-4. (876 aa)
	LOC101360881	Integrin beta; Belongs to the integrin beta chain family. (832 aa)
	LOC101353271	Guanine nucleotide exchange factor VAV3 isoform X1. (850 aa)
	LOC101341448	Catenin delta-1 isoform X1. (946 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340309	LOC101340566	A0A2Y9DTC0	A0A2Y9DUK4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.655
LOC101340309	LOC101341174	A0A2Y9DTC0	A0A2Y9DYB6	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.702
LOC101340309	LOC101342536	A0A2Y9DTC0	A0A2Y9E4F9	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.665
LOC101340309	LOC101344856	A0A2Y9DTC0	A0A2Y9QVG7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.	0.811
LOC101340309	LOC101346027	A0A2Y9DTC0	A0A2Y9EAF9	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.758
LOC101340309	LOC101346063	A0A2Y9DTC0	A0A2Y9DRI7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.683
LOC101340309	LOC101347064	A0A2Y9DTC0	A0A2Y9DC79	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.734
LOC101340309	LOC101347717	A0A2Y9DTC0	A0A2Y9D6S9	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664
LOC101340309	LOC101348240	A0A2Y9DTC0	A0A2Y9EBH3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.764
LOC101340309	LOC101348780	A0A2Y9DTC0	A0A2Y9DVX6	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.730
LOC101340309	LOC101348869	A0A2Y9DTC0	A0A2Y9DSF0	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Endothelial cell-selective adhesion molecule.	0.664
LOC101340309	LOC101349039	A0A2Y9DTC0	A0A2Y9DXA2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.771
LOC101340309	LOC101349513	A0A2Y9DTC0	A0A2Y9DCC9	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.697
LOC101340309	LOC101352970	A0A2Y9DTC0	A0A2Y9FXE8	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	LOW QUALITY PROTEIN: putative claudin-25.	0.656
LOC101340309	LOC101355465	A0A2Y9DTC0	A0A2Y9DYB8	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.694
LOC101340309	LOC101356055	A0A2Y9DTC0	A0A2Y9DUH4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.681
LOC101340309	LOC101356848	A0A2Y9DTC0	A0A2Y9G1G8	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664
LOC101340309	LOC101357857	A0A2Y9DTC0	A0A2Y9E9Q0	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.656
LOC101340309	LOC101358927	A0A2Y9DTC0	A0A2Y9DK30	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.765
LOC101340309	LOC101360113	A0A2Y9DTC0	A0A2Y9E9L4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.681