STRINGSTRING
LOC101354621 LOC101354621 LOC101342638 LOC101342638 LOC101346874 LOC101346874 LOC101349247 LOC101349247 LOC101348142 LOC101348142 LOC101353619 LOC101353619 LOC101351035 LOC101351035 LOC101346203 LOC101346203 LOC101350704 LOC101350704 LOC101344705 LOC101344705 LOC101357452 LOC101357452 LOC101356454 LOC101356454 LOC101361934 LOC101361934 LOC101348250 LOC101348250 LOC101345872 LOC101345872 LOC101347746 LOC101347746 LOC101357787 LOC101357787 LOC101341400 LOC101341400 LOC101344294 LOC101344294 LOC101344538 LOC101344538 LOC101357713 LOC101357713 LOC101346224 LOC101346224 LOC101347252 LOC101347252 LOC101349290 LOC101349290 LOC101346393 LOC101346393 LOC101361614 LOC101361614 LOC101361872 LOC101361872 LOC101341922 LOC101341922 LOC101352466 LOC101352466 LOC101356886 LOC101356886 LOC101353066 LOC101353066 LOC101355199 LOC101355199 LOC101352550 LOC101352550 LOC101360334 LOC101360334 LOC101355711 LOC101355711 LOC101354943 LOC101354943 LOC101344401 LOC101344401 LOC101352995 LOC101352995 LOC101351254 LOC101351254 LOC101352296 LOC101352296 LOC101359224 LOC101359224 LOC101346849 LOC101346849 LOC101343804 LOC101343804 LOC101346851 LOC101346851 LOC101353435 LOC101353435 LOC101354868 LOC101354868 LOC101353082 LOC101353082 LOC101349243 LOC101349243 LOC101358970 LOC101358970 LOC101354392 LOC101354392 LOC101356432 LOC101356432 LOC101353024 LOC101353024 LOC101351734 LOC101351734 LOC101350438 LOC101350438 LOC101358487 LOC101358487 LOC101358846 LOC101358846 LOC101361121 LOC101361121 LOC101345950 LOC101345950 LOC101350163 LOC101350163 LOC101356028 LOC101356028 LOC101342555 LOC101342555 LOC101359728 LOC101359728 LOC101359111 LOC101359111 LOC101349040 LOC101349040 LOC101343546 LOC101343546 LOC101361837 LOC101361837 LOC101359597 LOC101359597 LOC101348995 LOC101348995 LOC101355651 LOC101355651 LOC101346473 LOC101346473 LOC101345270 LOC101345270 LOC101350269 LOC101350269 LOC101341715 LOC101341715 LOC101347419 LOC101347419 LOC101344286 LOC101344286 LOC101346041 LOC101346041 LOC101353484 LOC101353484 LOC101347350 LOC101347350 LOC101358013 LOC101358013 LOC101345455 LOC101345455 LOC101355872 LOC101355872 LOC101358678 LOC101358678 LOC101346534 LOC101346534 LOC101349967 LOC101349967 LOC101346316 LOC101346316 LOC101348104 LOC101348104 LOC101361961 LOC101361961 LOC101344242 LOC101344242 LOC101353254 LOC101353254 LOC101347126 LOC101347126 LOC101359658 LOC101359658 LOC101361375 LOC101361375 LOC101347192 LOC101347192 LOC101344889 LOC101344889 LOC101356404 LOC101356404 LOC101346264 LOC101346264 LOC101351378 LOC101351378 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101354621Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (483 aa)
LOC101342638cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)
LOC101346874Cytochrome P450 2C21-like isoform X1; Belongs to the cytochrome P450 family. (490 aa)
LOC101349247Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC101348142Neuroendocrine secretory protein 55. (248 aa)
LOC101353619Prostaglandin E2 receptor EP2 subtype isoform X1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
LOC101351035Phosphatidylinositol 3-kinase regulatory subunit gamma. (462 aa)
LOC101346203Cytochrome P450 4A11-like; Belongs to the cytochrome P450 family. (510 aa)
LOC101350704Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
LOC101344705Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
LOC101357452Acid-sensing ion channel 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (533 aa)
LOC101356454Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LOC101361934Insulin-like growth factor I isoform X1. (189 aa)
LOC101348250Protein kinase C alpha type isoform X2. (549 aa)
LOC10134587285/88 kDa calcium-independent phospholipase A2 isoform X1. (836 aa)
LOC101347746Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LOC101357787Proteinase-activated receptor 2. (397 aa)
LOC101341400Arachidonate 12-lipoxygenase, 12S-type. (662 aa)
LOC101344294Transient receptor potential cation channel subfamily V member 1. (584 aa)
LOC101344538Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (733 aa)
LOC1013577135-hydroxytryptamine receptor 2A. (470 aa)
LOC101346224B1 bradykinin receptor. (354 aa)
LOC101347252B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (395 aa)
LOC101349290Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
LOC1013463931-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
LOC101361614Mitogen-activated protein kinase. (283 aa)
LOC101361872Mitogen-activated protein kinase. (366 aa)
LOC101341922Beta-nerve growth factor; Belongs to the NGF-beta family. (242 aa)
LOC101352466Mitogen-activated protein kinase. (595 aa)
LOC1013568865-hydroxytryptamine receptor 2C isoform X1. (458 aa)
LOC101353066Phospholipase A2. (818 aa)
LOC101355199Phospholipase A2. (850 aa)
LOC101352550Phospholipase A2. (784 aa)
LOC101360334Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (977 aa)
LOC101355711Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC101354943Phospholipase A2. (863 aa)
LOC101344401Acid-sensing ion channel 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (486 aa)
LOC101352995Kininogen-1 isoform X1. (428 aa)
LOC101351254Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC1013522961-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC101359224Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (486 aa)
LOC101346849Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101343804Phosphatidylinositol 3-kinase regulatory subunit beta. (729 aa)
LOC101346851Acid-sensing ion channel 2 isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (512 aa)
LOC101353435Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1; Belongs to the protein kinase superfamily. (499 aa)
LOC101354868Adenylate cyclase type 1. (903 aa)
LOC101353082Calcium/calmodulin-dependent protein kinase type II subunit beta. (655 aa)
LOC101349243Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
LOC101358970Acid-sensing ion channel 1 isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (560 aa)
LOC101354392Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
LOC1013564325-hydroxytryptamine receptor 2B. (478 aa)
LOC101353024Transient receptor potential cation channel subfamily M member 8. (1112 aa)
LOC101351734Mitogen-activated protein kinase. (464 aa)
LOC101350438Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1076 aa)
LOC101358487Calmodulin; Belongs to the calmodulin family. (113 aa)
LOC101358846LOW QUALITY PROTEIN: calmodulin-like protein 3; Belongs to the calmodulin family. (148 aa)
LOC101361121LOW QUALITY PROTEIN: calmodulin-like protein 6. (188 aa)
LOC101345950LOW QUALITY PROTEIN: cytochrome P450 4A11-like. (513 aa)
LOC101350163LOW QUALITY PROTEIN: cytochrome P450 2J2. (433 aa)
LOC101356028Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1212 aa)
LOC101342555Tyrosine-protein kinase. (542 aa)
LOC101359728Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (722 aa)
LOC101359111Calmodulin-like. (149 aa)
LOC101349040Interleukin-1 receptor accessory protein isoform X1. (687 aa)
LOC101343546Mitogen-activated protein kinase. (427 aa)
LOC101361837Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (922 aa)
LOC1013595971-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LOC101348995cAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
LOC101355651Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
LOC101346473Calmodulin-like protein 4. (153 aa)
LOC101345270Phospholipase A2. (757 aa)
LOC101350269Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa)
LOC101341715Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
LOC101347419Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (765 aa)
LOC101344286Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
LOC101346041Adenylate cyclase type 5. (1265 aa)
LOC101353484LOW QUALITY PROTEIN: acid-sensing ion channel 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (671 aa)
LOC101347350Mitogen-activated protein kinase. (321 aa)
LOC101358013Interleukin-1 receptor type 1. (572 aa)
LOC101345455Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC101355872Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (720 aa)
LOC101358678Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1082 aa)
LOC101346534Inositol 1,4,5-trisphosphate receptor type 1. (2715 aa)
LOC101349967Phosphoinositide phospholipase C. (909 aa)
LOC101346316Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (319 aa)
LOC101348104P2Y purinoceptor 2-like; Belongs to the G-protein coupled receptor 1 family. (336 aa)
LOC101361961Calcium/calmodulin-dependent protein kinase type II subunit gamma. (821 aa)
LOC1013442421-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
LOC101353254P2Y purinoceptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (429 aa)
LOC101347126Calmodulin-2 isoform X1; Belongs to the calmodulin family. (153 aa)
LOC101359658Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
LOC1013613751-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
LOC101347192Guanine nucleotide-binding protein G(Q) subunit alpha isoform X3. (381 aa)
LOC101344889Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (348 aa)
LOC101356404Inositol 1,4,5-trisphosphate receptor type 2. (2441 aa)
LOC101346264Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
LOC101351378Tyrosine-protein kinase receptor. (770 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (262 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
Server load: low (10%) [HD]