69 items (Trichechus manatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101344988	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	LOC101349743	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
	LOC101351897	Catenin beta-1. (781 aa)
	LOC101356840	Transforming protein RhoA. (193 aa)
	LOC101346883	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (211 aa)
	LOC101351035	Phosphatidylinositol 3-kinase regulatory subunit gamma. (462 aa)
	LOC101358300	wiskott-Aldrich syndrome protein family member 1. (559 aa)
	LOC101347740	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (218 aa)
	LOC101361501	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
	LOC101348926	Septin-12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (357 aa)
	LOC101347833	Hematopoietic lineage cell-specific protein. (498 aa)
	LOC101347746	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	LOC101344372	Actin, cytoplasmic 2. (375 aa)
	LOC101351144	Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
	LOC101360925	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
	LOC101342748	Adapter molecule crk isoform X1. (304 aa)
	LOC101361092	Fibronectin isoform X3. (2477 aa)
	LOC101343000	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
	LOC101361943	Cell division control protein 42 homolog isoform X1. (191 aa)
	LOC101356386	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
	LOC101352540	Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	LOC101359726	SHC-transforming protein 2. (428 aa)
	LOC101361102	Rho guanine nucleotide exchange factor 26 isoform X1. (863 aa)
	LOC101349633	Rho GTPase-activating protein 10. (785 aa)
	LOC101355014	GRB2-associated-binding protein 1 isoform X1. (724 aa)
	LOC101351164	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
	LOC101350907	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
	LOC101350153	Vinculin isoform X4. (1134 aa)
	LOC101360084	SHC-transforming protein 3. (616 aa)
	LOC101354286	Septin-8 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (484 aa)
	LOC101346849	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101343804	Phosphatidylinositol 3-kinase regulatory subunit beta. (729 aa)
	LOC101340853	Engulfment and cell motility protein 1. (719 aa)
	LOC101342874	E3 ubiquitin-protein ligase CBL isoform X1. (904 aa)
	LOC101355900	SHC-transforming protein 4. (629 aa)
	LOC101343640	Catenin alpha-3. (895 aa)
	LOC101355809	Crk-like protein. (303 aa)
	LOC101341862	Septin-2 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (397 aa)
	LOC101346861	Breast cancer anti-estrogen resistance protein 1. (840 aa)
	LOC101358105	SHC-transforming protein 1 isoform X1. (584 aa)
	LOC101346618	Integrin-linked protein kinase. (452 aa)
	LOC101345849	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	LOC101361873	CD2-associated protein isoform X1. (641 aa)
	LOC101343279	Dynamin-3 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
	LOC101359731	Neuronal-specific septin-3; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (257 aa)
	LOC101355384	Septin-1 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (365 aa)
	LOC101342555	Tyrosine-protein kinase. (542 aa)
	LOC101352216	Src substrate cortactin. (558 aa)
	LOC101352082	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1851 aa)
	LOC101347312	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	LOC101345595	Hepatocyte growth factor receptor. (1382 aa)
	LOC101350182	Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (884 aa)
	LOC101361749	Engulfment and cell motility protein 3. (421 aa)
	LOC101340808	Integrin alpha-5; Belongs to the integrin alpha chain family. (1062 aa)
	LOC101361865	Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
	LOC101356962	Dedicator of cytokinesis protein 1; Belongs to the DOCK family. (1865 aa)
	LOC101356054	Ras-related C3 botulinum toxin substrate 1. (148 aa)
	LOC101340374	wiskott-Aldrich syndrome protein family member 2. (498 aa)
	LOC101361370	Catenin alpha-1 isoform X1. (925 aa)
	LOC101358678	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1082 aa)
	LOC101354182	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (207 aa)
	LOC101348449	Rho-related GTP-binding protein RhoG. (191 aa)
	LOC101350735	Septin-11 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (438 aa)
	LOC101343265	Septin-6 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (428 aa)
	LOC101359658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	LOC101351714	Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
	LOC101361555	Neural Wiskott-Aldrich syndrome protein. (408 aa)
	LOC101360881	Integrin beta; Belongs to the integrin beta chain family. (832 aa)
	LOC101344591	Engulfment and cell motility protein 2 isoform X1. (720 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101340374	LOC101340853	A0A2Y9R7U9	A0A2Y9E1U9	wiskott-Aldrich syndrome protein family member 2.	Engulfment and cell motility protein 1.	0.410
LOC101340374	LOC101342555	A0A2Y9R7U9	A0A2Y9G0M3	wiskott-Aldrich syndrome protein family member 2.	Tyrosine-protein kinase.	0.438
LOC101340374	LOC101342748	A0A2Y9R7U9	A0A2Y9DKK8	wiskott-Aldrich syndrome protein family member 2.	Adapter molecule crk isoform X1.	0.522
LOC101340374	LOC101343000	A0A2Y9R7U9	A0A2Y9DKR8	wiskott-Aldrich syndrome protein family member 2.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.956
LOC101340374	LOC101344372	A0A2Y9R7U9	A0A2Y9DHB2	wiskott-Aldrich syndrome protein family member 2.	Actin, cytoplasmic 2.	0.935
LOC101340374	LOC101344591	A0A2Y9R7U9	A0A2Y9S3A9	wiskott-Aldrich syndrome protein family member 2.	Engulfment and cell motility protein 2 isoform X1.	0.451
LOC101340374	LOC101346861	A0A2Y9R7U9	A0A2Y9E613	wiskott-Aldrich syndrome protein family member 2.	Breast cancer anti-estrogen resistance protein 1.	0.544
LOC101340374	LOC101347746	A0A2Y9R7U9	A0A2Y9DH33	wiskott-Aldrich syndrome protein family member 2.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.400
LOC101340374	LOC101347833	A0A2Y9R7U9	A0A2Y9DFL5	wiskott-Aldrich syndrome protein family member 2.	Hematopoietic lineage cell-specific protein.	0.608
LOC101340374	LOC101348449	A0A2Y9R7U9	A0A2Y9RCZ1	wiskott-Aldrich syndrome protein family member 2.	Rho-related GTP-binding protein RhoG.	0.432
LOC101340374	LOC101349633	A0A2Y9R7U9	A0A2Y9DQN0	wiskott-Aldrich syndrome protein family member 2.	Rho GTPase-activating protein 10.	0.703
LOC101340374	LOC101349743	A0A2Y9R7U9	A0A2Y9D5W1	wiskott-Aldrich syndrome protein family member 2.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.952
LOC101340374	LOC101350907	A0A2Y9R7U9	A0A2Y9DUX6	wiskott-Aldrich syndrome protein family member 2.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.945
LOC101340374	LOC101351164	A0A2Y9R7U9	A0A2Y9DTM3	wiskott-Aldrich syndrome protein family member 2.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.945
LOC101340374	LOC101351714	A0A2Y9R7U9	A0A2Y9RQW3	wiskott-Aldrich syndrome protein family member 2.	Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.404
LOC101340374	LOC101352216	A0A2Y9R7U9	A0A2Y9G1M9	wiskott-Aldrich syndrome protein family member 2.	Src substrate cortactin.	0.616
LOC101340374	LOC101354182	A0A2Y9R7U9	A0A2Y9RCC5	wiskott-Aldrich syndrome protein family member 2.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.957
LOC101340374	LOC101355809	A0A2Y9R7U9	A0A2Y9E4X1	wiskott-Aldrich syndrome protein family member 2.	Crk-like protein.	0.507
LOC101340374	LOC101356054	A0A2Y9R7U9	A0A2Y9R6N8	wiskott-Aldrich syndrome protein family member 2.	Ras-related C3 botulinum toxin substrate 1.	0.946
LOC101340374	LOC101358300	A0A2Y9R7U9	A0A2Y9DDC4	wiskott-Aldrich syndrome protein family member 2.	wiskott-Aldrich syndrome protein family member 1.	0.967