100 items (Trichechus manatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101346179	Ras-related protein Rab-7a. (207 aa)
	LOC101354877	Laminin subunit beta-2. (1799 aa)
	LOC101355304	Arginase. (330 aa)
	LOC101360625	Complement component C8 beta chain. (590 aa)
	LOC101342638	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)
	LOC101348142	Neuroendocrine secretory protein 55. (248 aa)
	LOC101344352	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	LOC101359687	Alpha-actinin-1 isoform X3. (914 aa)
	LOC101358028	Transforming growth factor beta-3. (457 aa)
	LOC101357435	Arginase. (354 aa)
	LOC101351035	Phosphatidylinositol 3-kinase regulatory subunit gamma. (462 aa)
	LOC101352766	Peroxiredoxin-1. (199 aa)
	LOC101360565	Laminin subunit gamma-2. (1191 aa)
	LOC101360306	Laminin subunit gamma-1. (1608 aa)
	LOC101356454	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	LOC101348250	Protein kinase C alpha type isoform X2. (549 aa)
	LOC101347746	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	LOC101342743	Interleukin-10. (178 aa)
	LOC101346216	Ras-related protein Rab-7b isoform X1. (200 aa)
	LOC101340544	Laminin subunit beta-3. (1171 aa)
	LOC101342240	Laminin subunit gamma-3. (1580 aa)
	LOC101347669	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	LOC101361092	Fibronectin isoform X3. (2477 aa)
	LOC101351590	Interleukin-6. (237 aa)
	LOC101354262	Collagen alpha-1(I) chain. (1460 aa)
	LOC101345890	Guanine nucleotide-binding protein subunit alpha-11. (354 aa)
	LOC101349964	Collagen alpha-5(IV) chain isoform X2. (1691 aa)
	LOC101351866	Nuclear factor NF-kappa-B p105 subunit isoform X1. (997 aa)
	LOC101351254	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	LOC101360165	LOW QUALITY PROTEIN: laminin subunit beta-4. (1784 aa)
	LOC101351432	Laminin subunit beta-1. (1786 aa)
	LOC101350153	Vinculin isoform X4. (1134 aa)
	LOC101345564	Collagen alpha-2(IV) chain. (1710 aa)
	LOC101347445	Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
	LOC101352296	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	LOC101358515	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (106 aa)
	LOC101357988	C-X-C motif chemokine. (104 aa)
	LOC101346849	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101343804	Phosphatidylinositol 3-kinase regulatory subunit beta. (729 aa)
	LOC101349050	Integrin beta. (773 aa)
	LOC101355897	Collagen alpha-3(IV) chain. (1670 aa)
	LOC101358523	Ras-related protein Rab-5A. (215 aa)
	LOC101354868	Adenylate cyclase type 1. (903 aa)
	LOC101346169	Guanine nucleotide-binding protein G(Olf) subunit alpha. (380 aa)
	LOC101341020	Collagen alpha-2(I) chain isoform X2. (1367 aa)
	LOC101346429	Interferon gamma. (210 aa)
	LOC101356677	Laminin subunit alpha-3 isoform X1. (3323 aa)
	LOC101354388	Mucin-2. (2635 aa)
	LOC101349773	Ras-related protein Rab-7a-like. (196 aa)
	LOC101356948	T-cell surface glycoprotein CD1b isoform X1. (332 aa)
	LOC101345916	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (209 aa)
	LOC101352768	Cathepsin G-like; Belongs to the peptidase S1 family. (250 aa)
	LOC101356950	Complement component C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (243 aa)
	LOC101356509	Laminin subunit alpha-2. (2959 aa)
	LOC101352772	Laminin subunit alpha-4. (1680 aa)
	LOC101349706	Collagen alpha-6(IV) chain. (1713 aa)
	LOC101344479	LOW QUALITY PROTEIN: monocyte differentiation antigen CD14. (377 aa)
	LOC101349415	Complement component C8 alpha chain. (540 aa)
	LOC101356579	Nitric oxide synthase; Produces nitric oxide (NO). (1161 aa)
	LOC101347367	Laminin subunit alpha-1. (2407 aa)
	LOC101357684	Laminin subunit alpha-5. (3782 aa)
	LOC101345305	Collagen alpha-1(IV) chain. (1643 aa)
	LOC101344772	T-cell surface glycoprotein CD1a-like. (186 aa)
	LOC101361837	Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (922 aa)
	LOC101357195	LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1c. (328 aa)
	LOC101355167	T-cell surface glycoprotein CD1e, membrane-associated isoform X1. (389 aa)
	LOC101348995	cAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
	LOC101357446	LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1b-like. (237 aa)
	LOC101354307	Caspase-3 isoform X1; Belongs to the peptidase C14A family. (277 aa)
	LOC101354649	Ras-related protein Rab-5C. (163 aa)
	TNF	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (234 aa)
	LOC101353470	Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	LOC101353752	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
	LOC111820845	LOW QUALITY PROTEIN: uncharacterized protein LOC111820845. (355 aa)
	LOC101355194	Ras-related protein Rab-5B. (215 aa)
	LOC101358013	Interleukin-1 receptor type 1. (572 aa)
	LOC101344340	Interleukin-1 receptor type 2 isoform X1. (417 aa)
	LOC101358678	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1082 aa)
	LOC101349967	Phosphoinositide phospholipase C. (909 aa)
	LOC101342847	Toll-like receptor 2; Belongs to the Toll-like receptor family. (783 aa)
	LOC101349386	Serpin B10; Belongs to the serpin family. (397 aa)
	LOC101344727	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
	LOC101344242	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
	LOC101342634	LOW QUALITY PROTEIN: laminin subunit beta-1-like. (884 aa)
	LOC101346678	C-X-C motif chemokine. (104 aa)
	LOC101359658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	LOC101357995	Granulocyte-macrophage colony-stimulating factor. (137 aa)
	LOC101358346	Collagen alpha-4(IV) chain. (1708 aa)
	LOC101361375	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
	LOC101347192	Guanine nucleotide-binding protein G(Q) subunit alpha isoform X3. (381 aa)
	LOC101361706	Transcription factor p65. (538 aa)
	LOC101357920	Integrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1153 aa)
	LOC101351714	Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
	LOC101351447	Serpin B9 isoform X1; Belongs to the serpin family. (408 aa)
	LOC101351715	Serpin B6 isoform X1; Belongs to the serpin family. (378 aa)
	LOC101348555	LOW QUALITY PROTEIN: complement component C9. (539 aa)
	LOC101351810	Alpha-actinin-4. (876 aa)
	LOC101359491	Collagen alpha-1(III) chain. (1160 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (262 aa)
	LOC101342543	Transforming growth factor beta; Belongs to the TGF-beta family. (392 aa)

Your Current Organism:

Trichechus manatus

NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1B	LOC101342543	A0A2Y9RYF7	A0A2Y9S2X2	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.623
IL1B	LOC101342743	A0A2Y9RYF7	A0A2Y9DIE0	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-10.	0.844
IL1B	LOC101344340	A0A2Y9RYF7	A0A2Y9R8D2	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1 receptor type 2 isoform X1.	0.995
IL1B	LOC101344352	A0A2Y9RYF7	A0A2Y9DAZ4	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.480
IL1B	LOC101346429	A0A2Y9RYF7	A0A2Y9E5B3	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interferon gamma.	0.772
IL1B	LOC101346678	A0A2Y9RYF7	A0A2Y9RGK5	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	C-X-C motif chemokine.	0.554
IL1B	LOC101349050	A0A2Y9RYF7	A0A2Y9E2D4	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Integrin beta.	0.428
IL1B	LOC101351590	A0A2Y9RYF7	A0A2Y9DMT4	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-6.	0.861
IL1B	LOC101351866	A0A2Y9RYF7	A0A2Y9DTW8	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.970
IL1B	LOC101353470	A0A2Y9RYF7	A0A2Y9QV04	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.719
IL1B	LOC101354307	A0A2Y9RYF7	A0A2Y9QML3	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.676
IL1B	LOC101355304	A0A2Y9RYF7	A0A2Y9D6Z7	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Arginase.	0.537
IL1B	LOC101356579	A0A2Y9RYF7	A0A2Y9FZT2	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.523
IL1B	LOC101357988	A0A2Y9RYF7	A0A2Y9DY97	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	C-X-C motif chemokine.	0.554
IL1B	LOC101357995	A0A2Y9RYF7	A0A2Y9RK19	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Granulocyte-macrophage colony-stimulating factor.	0.757
IL1B	LOC101358013	A0A2Y9RYF7	A0A2Y9R8B9	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1 receptor type 1.	0.985
IL1B	LOC101358515	A0A2Y9RYF7	A0A2Y9DY26	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.864
IL1B	LOC101361706	A0A2Y9RYF7	A0A2Y9RPW9	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Transcription factor p65.	0.966
IL1B	TNF	A0A2Y9RYF7	A0A2Y9QPJ3	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family.	0.849
LOC101340544	LOC101342240	A0A2Y9DJ80	A0A2Y9DJX4	Laminin subunit beta-3.	Laminin subunit gamma-3.	0.673