STRINGSTRING
LOC101357840 LOC101357840 LOC101353013 LOC101353013 LOC101359592 LOC101359592 LOC101346361 LOC101346361 LOC101341290 LOC101341290 LOC101357348 LOC101357348 LOC101358028 LOC101358028 LOC101347392 LOC101347392 LOC101351035 LOC101351035 LOC101357779 LOC101357779 LOC101359953 LOC101359953 LOC101342476 LOC101342476 LOC101345867 LOC101345867 LOC101359012 LOC101359012 LOC101359617 LOC101359617 LOC101347746 LOC101347746 LOC101343332 LOC101343332 LOC101340702 LOC101340702 LOC101344857 LOC101344857 LOC101341732 LOC101341732 LOC101347669 LOC101347669 LOC101342748 LOC101342748 LOC101355353 LOC101355353 LOC101355952 LOC101355952 LOC101360493 LOC101360493 LOC101354258 LOC101354258 LOC101359726 LOC101359726 LOC101341078 LOC101341078 LOC101348099 LOC101348099 LOC101344230 LOC101344230 LOC101351866 LOC101351866 LOC101356564 LOC101356564 LOC101359745 LOC101359745 LOC101360084 LOC101360084 LOC101347525 LOC101347525 LOC101346679 LOC101346679 LOC101346849 LOC101346849 LOC101343804 LOC101343804 LOC101361119 LOC101361119 LOC101342874 LOC101342874 LOC101355900 LOC101355900 LOC101340589 LOC101340589 LOC101355809 LOC101355809 LOC101360273 LOC101360273 LOC101349998 LOC101349998 LOC101358105 LOC101358105 LOC101341201 LOC101341201 LOC101347574 LOC101347574 LOC101343407 LOC101343407 LOC101356099 LOC101356099 LOC101353421 LOC101353421 LOC101350664 LOC101350664 LOC101349408 LOC101349408 LOC101346946 LOC101346946 LOC101354148 LOC101354148 LOC101342804 LOC101342804 LOC101351589 LOC101351589 LOC101357556 LOC101357556 LOC101350197 LOC101350197 LOC101349786 LOC101349786 LOC101348102 LOC101348102 LOC101355276 LOC101355276 LOC101351852 LOC101351852 LOC101346505 LOC101346505 LOC101358678 LOC101358678 LOC101342008 LOC101342008 LOC101358763 LOC101358763 LOC101342024 LOC101342024 LOC101351256 LOC101351256 LOC101359658 LOC101359658 LOC101361706 LOC101361706 LOC101352047 LOC101352047 LOC101358526 LOC101358526 LOC101357079 LOC101357079 LOC101342543 LOC101342543
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101357840RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC101353013Growth arrest and DNA damage-inducible protein GADD45 alpha. (162 aa)
LOC101359592Son of sevenless homolog 1 isoform X1. (1333 aa)
LOC101346361Bcl-2-like protein 1 isoform X1. (233 aa)
LOC101341290Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
LOC101357348Transcription factor E2F1. (461 aa)
LOC101358028Transforming growth factor beta-3. (457 aa)
LOC101347392Son of sevenless homolog 2 isoform X1. (1328 aa)
LOC101351035Phosphatidylinositol 3-kinase regulatory subunit gamma. (462 aa)
LOC101357779Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
LOC101359953Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
LOC101342476Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
LOC101345867Cyclin-dependent kinase inhibitor 2A. (152 aa)
LOC101359012Growth factor receptor-bound protein 2. (176 aa)
LOC101359617DNA polymerase kappa isoform X1. (865 aa)
LOC101347746Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LOC101343332Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC101340702C-terminal-binding protein 2 isoform X1. (989 aa)
LOC101344857Mothers against decapentaplegic homolog. (425 aa)
LOC101341732Tyrosine-protein kinase. (1142 aa)
LOC101347669Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC101342748Adapter molecule crk isoform X1. (304 aa)
LOC101355353NF-kappa-B inhibitor alpha. (314 aa)
LOC101355952Retinoblastoma-associated protein isoform X3. (938 aa)
LOC101360493Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC101354258TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC101359726SHC-transforming protein 2. (428 aa)
LOC101341078Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC101348099Growth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
LOC101344230GTPase NRas isoform X1. (189 aa)
LOC101351866Nuclear factor NF-kappa-B p105 subunit isoform X1. (997 aa)
LOC101356564Apoptosis regulator BAX. (173 aa)
LOC101359745G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LOC101360084SHC-transforming protein 3. (616 aa)
LOC101347525GTPase KRas isoform X3. (227 aa)
LOC101346679Transcription factor E2F3 isoform X1. (459 aa)
LOC101346849Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101343804Phosphatidylinositol 3-kinase regulatory subunit beta. (729 aa)
LOC101361119Growth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC101342874E3 ubiquitin-protein ligase CBL isoform X1. (904 aa)
LOC101355900SHC-transforming protein 4. (629 aa)
LOC101340589Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
LOC101355809Crk-like protein. (303 aa)
LOC101360273Cyclin-dependent kinase inhibitor 1B. (198 aa)
LOC101349998DNA damage-binding protein 2. (464 aa)
LOC101358105SHC-transforming protein 1 isoform X1. (584 aa)
LOC101341201Bcl-2 homologous antagonist/killer. (212 aa)
LOC101347574NF-kappa-B essential modulator isoform X1. (421 aa)
LOC101343407Signal transducer and activator of transcription. (799 aa)
LOC101356099Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC101353421Serine/threonine-protein kinase B-raf. (743 aa)
LOC101350664MDS1 and EVI1 complex locus protein EVI1 isoform X1. (1227 aa)
LOC101349408E3 ubiquitin-protein ligase Mdm2 isoform X1. (498 aa)
LOC101346946Breakpoint cluster region protein. (840 aa)
LOC101354148Signal transducer and activator of transcription 5B. (581 aa)
LOC101342804GTPase HRas isoform X1. (189 aa)
LOC101351589Serine/threonine-protein kinase A-Raf. (611 aa)
LOC101357556Transcription factor E2F2. (434 aa)
LOC101350197Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (393 aa)
LOC101349786Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
LOC101348102Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LOC101355276Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (381 aa)
LOC101351852Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
LOC101346505GRB2-associated-binding protein 2. (640 aa)
LOC101358678Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1082 aa)
LOC101342008Cyclin-dependent kinase inhibitor 1 isoform X1. (189 aa)
LOC101358763Mothers against decapentaplegic homolog. (552 aa)
LOC101342024C-terminal-binding protein 1. (485 aa)
LOC101351256Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC101359658Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
LOC101361706Transcription factor p65. (538 aa)
LOC101352047Bcl2-associated agonist of cell death. (167 aa)
LOC101358526Mitogen-activated protein kinase 1. (263 aa)
LOC101357079Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (466 aa)
LOC101342543Transforming growth factor beta; Belongs to the TGF-beta family. (392 aa)
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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